{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:17:41Z","timestamp":1784715461687,"version":"3.55.0"},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,2]]},"abstract":"<jats:p>Human strongyloidiasis is widely prevalent in tropical and subtropical regions worldwide but is not endemic in Hawaii. Subclinical, chronic infections may be lifelong; immunosuppressive therapy, particularly with glucocorticoids, may lead to serious or fatal disseminated disease, which is preventable. We performed a retrospective analysis of patients tested for <jats:italic>Strongyloides<\/jats:italic> immunoglobulin G antibody in an academic medical center in Honolulu, Hawaii, from 2005 to 2012. Of the 475 patients tested, 78 (16%) were seropositive. The largest proportion of seropositive cases was found among Micronesians (30%), Polynesians (26%), Filipinos (13%), and Southeast Asians (11%). Among the seropositive patients, the most likely reason for clinicians to order testing was blood eosinophilia. Stool parasite examination results were available for 58% of seropositive patients of which 11% were positive for <jats:italic>Strongyloides stercoralis<\/jats:italic> larvae. Antihelminthic therapy, usually ivermectin, was ordered for 71% of patients. After treatment, blood eosinophilia and <jats:italic>Strongyloides<\/jats:italic> serology results were reassessed for 76% and 35% of patients, respectively; both tests tended to show improvement. Travelers and immigrants from <jats:italic>Strongyloides<\/jats:italic>-endemic areas, including Micronesia and Polynesia, should have serodiagnostic testing for latent strongyloidiasis, and if positive, treated empirically with ivermectin, particularly when corticosteroids or other immunosuppressive therapies are anticipated.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0157","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:01:00Z","timestamp":1529996460000},"page":"370-374","source":"Crossref","is-referenced-by-count":8,"title":["Human Strongyloidiasis in Hawaii: A Retrospective Review of Enzyme-Linked Immunosorbent Assay Serodiagnostic Testing"],"prefix":"10.4269","volume":"99","author":[{"given":"Matthew J.","family":"Akiyama","sequence":"first","affiliation":[{"name":"Department of Medicine, Montefiore Medical Center\/Albert Einstein College of Medicine, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii;"},{"name":"The Queens Medical Center, Honolulu, Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Trans R Soc Trop Med Hyg","first-page":"967","article-title":"Strongyloidiasis\u2014the most neglected of the neglected tropical diseases?","volume":"103","author":"Olsen","year":"2009"},{"key":"b2","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"14","article-title":"Disseminated strongyloidiasis: a retrospective study of clinical course and outcome","volume":"25","author":"Lam","year":"2006"},{"key":"b3","series-title":"J Travel Med","first-page":"233","article-title":"Undiagnosed and potentially lethal parasite infections among immigrants and refugees in Australia","volume":"13","author":"Caruana","year":"2006"},{"key":"b4","series-title":"Epidemiol Infect","first-page":"439","article-title":"Chronic Strongyloides stercoralis infection in Laotian immigrants and refugees 7\u201320 years after resettlement in Australia","volume":"128","author":"de Silva","year":"2002"},{"key":"b5","series-title":"Am J Epidemiol","first-page":"257","article-title":"Seroepidemiology of Strongyloides infection in the southeast Asian refugee population in Canada","volume":"132","author":"Gyorkos","year":"1990"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"749","article-title":"Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area","volume":"66","author":"Loutfy","year":"2002"},{"key":"b7","series-title":"Expert Opin Pharmacother","first-page":"2615","article-title":"Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis","volume":"5","author":"Igual-Adell","year":"2004"},{"key":"b8","series-title":"N Engl J Med","first-page":"773","article-title":"The cost effectiveness of strategies for the treatment of intestinal parasites in immigrants","volume":"340","author":"Muennig","year":"1999"},{"key":"b9","series-title":"Epidemiol Infect","first-page":"1055","article-title":"The cost-effectiveness of ivermectin vs. albendazole in the presumptive treatment of strongyloidiasis in immigrants to the United States","volume":"132","author":"Muennig","year":"2004"},{"key":"b10","author":"Centers for Disease Control","year":"2016"},{"key":"b11","series-title":"Am J Med","first-page":"545.e1-8","article-title":"Maltreatment of Strongyloides infection: case series and worldwide physicians-in-training survey","volume":"120","author":"Boulware","year":"2007"},{"key":"b12","series-title":"Hawaii Med J","first-page":"59","article-title":"Strongyloides infection in Hawaii: an imported case","volume":"52","author":"Yoshimoto","year":"1993"},{"key":"b13","series-title":"Acta Trop","first-page":"227","article-title":"Occurrence of and risk factors for Strongyloides stercoralis infection in south-east Asia","volume":"159","author":"Schar","year":"2016"},{"key":"b14","series-title":"Am J Trop Med Hyg","first-page":"365","article-title":"Relationship among Strongyloides stercoralis infection, human T-cell lymphotropic virus type 1 infection, and cancer: a 24-year cohort inpatient study in Okinawa, Japan","volume":"94","author":"Tanaka","year":"2016"},{"key":"b15","series-title":"Nephrol Dial Transplant","first-page":"1310","article-title":"High prevalence and presumptive treatment of schistosomiasis and strongyloidiasis among African refugees","volume":"45","author":"Posey","year":"2007"},{"key":"b16","series-title":"J Travel Med","first-page":"80","article-title":"Imported strongyloidosis: a longitudinal analysis of 31 cases","volume":"12","author":"Nuesch","year":"2005"},{"key":"b17","series-title":"QJM","first-page":"789","article-title":"Chronic Strongyloides stercoralis infection in former British Far East prisoners of war","volume":"97","author":"Gill","year":"2004"},{"key":"b18","series-title":"Jpn J Med","first-page":"96","article-title":"Fatal strongyloidiasis latent over 42 years in the antineoplastic chemotherapy of a case with malignant lymphoma","volume":"28","author":"Suzuki","year":"1989"},{"key":"b19","series-title":"PLoS Negl Trop Dis","first-page":"e2640","article-title":"Diagnostic accuracy of five serologic tests for Strongyloides stercoralis infection","volume":"8","author":"Bisoffi","year":"2014"},{"key":"b20","series-title":"PLoS Negl Trop Dis","first-page":"e2002","article-title":"The laboratory diagnosis and follow up of strongyloidiasis: a systematic review","volume":"7","author":"Requena-Mendez","year":"2013"},{"key":"b21","series-title":"J Clin Pathol","first-page":"551","article-title":"Diagnosis of human toxocariasis by antigen capture enzyme linked immunosorbent assay","volume":"46","author":"Gillespie","year":"1993"},{"key":"b22","series-title":"Parasit Vectors","first-page":"486","article-title":"Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012","volume":"9","author":"Nguyen","year":"2016"},{"key":"b23","series-title":"N Engl J Med","first-page":"1592","article-title":"Eosinophilia","volume":"338:","author":"Rothenberg","year":"1998"},{"key":"b24","series-title":"Arch Intern Med","first-page":"1257","article-title":"Clinical and epidemiologic features of strongyloidiasis. A prospective study in rural Tennessee","volume":"147","author":"Berk","year":"1987"},{"key":"b25","series-title":"Malays J Pathol","first-page":"71","article-title":"Review of patients with Strongyloides stercoralis infestation in a tertiary teaching hospital, Kelantan","volume":"35","author":"Azira","year":"2013"},{"key":"b26","series-title":"Nephrol Dial Transplant","first-page":"1040","article-title":"Diagnosis of Strongyloides stercoralis infection","volume":"33","author":"Siddiqui","year":"2001"},{"key":"b27","series-title":"Am J Trop Med Hyg","first-page":"657","article-title":"Intestinal parasites among African refugees resettled in Massachusetts and the impact of an overseas pre-departure treatment program","volume":"69","author":"Geltman","year":"2003"},{"key":"b28","series-title":"Comput Methods Programs Biomed","first-page":"11","article-title":"Tuberculosis diagnosis support analysis for precarious health information systems","volume":"157","author":"Orjuela-Canon","year":"2018"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/2\/article-p370.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/2\/article-p370.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/2\/article-p370.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T19:29:32Z","timestamp":1722454172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/2\/article-p370.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,2]]},"references-count":28,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0157","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,2]]}}}