{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:29:40Z","timestamp":1778261380692,"version":"3.51.4"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,5]]},"abstract":"<jats:p>We report two cases of corneal coinfection with <jats:italic>Acanthamoeba<\/jats:italic> and <jats:italic>Fusarium<\/jats:italic> sp. along with the review of published literature. A 35-year-old woman and 65-year-old man presented to the institute with corneal ulcer refractory for treatment with topical antibiotics. Microbiological examination revealed the presence of <jats:italic>Acanthamoeba<\/jats:italic> cysts along with septate, hyaline fungal filaments. After emergency therapeutic penetrating keratoplasty (TPK) in both, the corneal tissue was sent for histopathologic examination, which confirmed the presence of <jats:italic>Acanthamoeba<\/jats:italic> and fungal coinfection. One patient had a recurrence of fungal infection after TPK. In subjects with a rapid progression of mycotic ulcer, coinfection with other microorganisms including <jats:italic>Acanthamoeba<\/jats:italic> should be suspected. The two cases presented here emphasize the importance of microbiology in making prompt diagnosis and appropriate management of these cases at an early stage.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0158","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T07:00:25Z","timestamp":1531810825000},"page":"805-808","source":"Crossref","is-referenced-by-count":16,"title":["Case Report: Corneal Coinfection with Fungus and Amoeba: Report of Two Patients and Literature Review"],"prefix":"10.4269","volume":"99","author":[{"given":"Joveeta","family":"Joseph","sequence":"first","affiliation":[{"name":"Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Tej Kohli Cornea Institute, L. V. Prasad Eye Institute, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savitri","family":"Sharma","sequence":"additional","affiliation":[{"name":"Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Cornea","first-page":"555","article-title":"The Epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in south India","volume":"21","author":"Gopinathan","year":"2002"},{"key":"b2","series-title":"Br J Ophthalmol","first-page":"1103","article-title":"Patients characteristics, diagnosis and treatment of non-contact lens related Acanthamoeba keratitis","volume":"84","author":"Sharma","year":"2000"},{"key":"b3","series-title":"Acta Trop","first-page":"102","article-title":"Acanthamoeba and Fusarium interactions: a possible problem in keratitis","volume":"157","author":"Nunes","year":"2016"},{"key":"b4","series-title":"Am J Ophthalmol","first-page":"508","article-title":"Acanthamoeba keratitis associated with fungal keratitis","volume":"131","author":"Froumis","year":"2001"},{"key":"b5","series-title":"Kaohsiung J Med Sci","first-page":"665","article-title":"Treatment of Acanthamoeba keratitis combined with fungal infection with polyhexamethylene biguanide","volume":"15","author":"Tien","year":"1999"},{"key":"b6","series-title":"Eye Contact Lens","first-page":"185","article-title":"Acanthamoeba and fungal keratitis in a woman with a history of intacs corneal implants","volume":"34","author":"Slade","year":"2008"},{"key":"b7","series-title":"Cornea","first-page":"210","article-title":"Concurrent Acanthamoeba and Fusarium keratitis with silicone hydrogel contact lens use","volume":"29","author":"Lee","year":"2010"},{"key":"b8","series-title":"Acta Ophthalmol","first-page":"199","article-title":"Medical treatment for combined Fusarium and Acanthamoeba keratitis","volume":"87","author":"Lin","year":"2009"},{"key":"b9","series-title":"Int J Clin Pract","first-page":"549","article-title":"Clinical experience in managing Fusarium solani keratitis","volume":"59","author":"Lin","year":"2005"},{"key":"b10","series-title":"Indian J Ophthalmol","first-page":"273","article-title":"Review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade","volume":"57","author":"Gopinathan","year":"2009"},{"key":"b11","author":"Luna","year":"1968"},{"key":"b12","series-title":"Indian J Med Res","first-page":"749","article-title":"Analysis of the risk factors predisposing to fungal, bacterial & Acanthamoeba keratitis in south India","volume":"130","author":"Bharathi","year":"2009"},{"key":"b13","series-title":"Indian J Med Microbiol","first-page":"67","article-title":"Acanthamoeba keratitis with Curvularia co-infection","volume":"28","author":"Gupta","year":"2010"},{"key":"b14","series-title":"Cornea","first-page":"112","article-title":"Corneal coinfection with Scedosporium apiospermum and Acanthamoeba after sewage contaminated ocular injury","volume":"20","author":"Rumelt","year":"2001"},{"key":"b15","series-title":"Am J Ophthalmol","first-page":"798","article-title":"Infection after radial keratotomy","volume":"119","author":"Gussler","year":"1995"},{"key":"b16","series-title":"Eye (Lond)","first-page":"271","article-title":"Combined fungal and Acanthamoeba keratitis: diagnosis by in vivo confocal microscopy","volume":"21","author":"Babu","year":"2007"},{"key":"b17","series-title":"Invest Ophthalmol Vis Sci","first-page":"2087","article-title":"Potential role of macrophages in experimental keratomycosis","volume":"50","author":"Hu","year":"2009"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/3\/article-p805.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/3\/article-p805.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/3\/article-p805.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:14:55Z","timestamp":1722431695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/3\/article-p805.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":17,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0158","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,5]]}}}