{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:45:55Z","timestamp":1787499955819,"version":"build-2736575974"},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,3]]},"abstract":"<jats:p>Pulmonary tuberculosis (PTB) is associated with modulation of levels of adipokines, specifically adiponectin and leptin, but the effect of standard antituberculosis treatment (ATT) on the systemic levels of adiponectin, resistin, and leptin has not been well explored. To identify the association of adipokines with PTB and their relationship with disease severity and bacterial burden, we measured the levels of adiponectin, resistin, and leptin in PTB individuals and compared them with latent tuberculosis (LTB) and healthy control (HC) individuals. Pulmonary tuberculosis was characterized by diminished circulating levels of adiponectin and leptin and heightened circulating levels of resistin in comparison to that in LTB and HC individuals. However, PTB with bilateral or cavitary disease did not exhibit any increased systemic levels of these adipokines in comparison with those with unilateral or non-cavitary disease, respectively. In addition, none of the adipokines exhibited a positive correlation with bacterial burdens, but adiponectin alone exhibited a negative correlation with body mass index in PTB individuals. Finally, on successful completion of ATT, PTB individuals exhibited significantly increased levels of adiponectin and leptin and significantly decreased levels of resistin. Therefore, our data identify an important association of systemic adipokine levels with PTB disease and its alteration following ATT.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0206","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T03:00:50Z","timestamp":1536116450000},"page":"875-880","source":"Crossref","is-referenced-by-count":12,"title":["Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment"],"prefix":"10.4269","volume":"99","author":[{"given":"Kadar","family":"Moideen","sequence":"first","affiliation":[{"name":"National Institutes of Health\u2014International Center for Excellence in Research, Chennai, India;"},{"name":"National Institute for Research in Tuberculosis, Chennai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathella Pavan","family":"Kumar","sequence":"additional","affiliation":[{"name":"National Institutes of Health\u2014International Center for Excellence in Research, Chennai, India;"},{"name":"National Institute for Research in Tuberculosis, Chennai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Nair","sequence":"additional","affiliation":[{"name":"National Institute for Research in Tuberculosis, Chennai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaithilingam V.","family":"Banurekha","sequence":"additional","affiliation":[{"name":"National Institute for Research in Tuberculosis, Chennai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subash","family":"Babu","sequence":"additional","affiliation":[{"name":"National Institutes of Health\u2014International Center for Excellence in Research, Chennai, India;"},{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 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diabetes","volume":"109","author":"Kusminski","year":"2005"},{"key":"b6","series-title":"J Clin Invest","first-page":"115","article-title":"CCR2 modulates inflammatory and metabolic effects of high-fat feeding","volume":"116","author":"Weisberg","year":"2006"},{"key":"b7","series-title":"Hormones (Athens)","first-page":"8","article-title":"Adiponectin: regulation of its production and its role in human diseases","volume":"11","author":"Shehzad","year":"2012"},{"key":"b8","series-title":"J Biol Chem","first-page":"36896","article-title":"Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells","volume":"287","author":"Cheng","year":"2012"},{"key":"b9","series-title":"J Immunol","first-page":"5789","article-title":"Resistin, an adipokine with potent proinflammatory properties","volume":"174","author":"Bokarewa","year":"2005"},{"key":"b10","series-title":"Nat Clin Pract Endocrinol Metab","first-page":"705","article-title":"Ghrelin, obesity and diabetes","volume":"3","author":"Wiedmer","year":"2007"},{"key":"b11","series-title":"Drug Discov Today","first-page":"276","article-title":"Physiological, pathological and potential therapeutic roles of ghrelin","volume":"12","author":"Leite-Moreira","year":"2007"},{"key":"b12","series-title":"Mediators Inflamm","first-page":"568343","article-title":"Role of leptin in the activation of immune cells","volume":"2010","author":"Fernandez-Riejos","year":"2010"},{"key":"b13","series-title":"Clin Nutr","first-page":"512","article-title":"Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis","volume":"29","author":"Kim","year":"2010"},{"key":"b14","series-title":"J Clin Endocrinol Metab","first-page":"758","article-title":"Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation","volume":"87","author":"van Crevel","year":"2002"},{"key":"b15","series-title":"PLoS One","first-page":"e38703","article-title":"Circulating levels of adiponectin, leptin, fetuin-A and retinol-binding protein in patients with tuberculosis: markers of metabolism and inflammation","volume":"7","author":"Keicho","year":"2012"},{"key":"b16","series-title":"Tuberculosis (Edinb)","first-page":"293","article-title":"Treatment end point determinants for pulmonary tuberculosis: human resistin as a surrogate biomarker","volume":"91","author":"Ehtesham","year":"2011"},{"key":"b17","series-title":"J Assoc Physicians India","first-page":"863","article-title":"The Chennai Urban Rural Epidemiology Study (CURES)\u2013study design and methodology (urban component) (CURES-I)","volume":"51","author":"Deepa","year":"2003"},{"key":"b18","series-title":"ISRN Inflamm","first-page":"139239","article-title":"Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines","volume":"2013","author":"Makki","year":"2013"},{"key":"b19","series-title":"Int Immunopharmacol","first-page":"604","article-title":"Novel immunomodulatory effects of adiponectin on dendritic cell functions","volume":"11","author":"Tsang","year":"2011"},{"key":"b20","series-title":"PLoS One","first-page":"e26363","article-title":"A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis","volume":"6","author":"Santucci","year":"2011"},{"key":"b21","series-title":"PLoS One","first-page":"e54564","article-title":"Gut hormones, appetite suppression and cachexia in patients with pulmonary TB","volume":"8","author":"Chang","year":"2013"},{"key":"b22","series-title":"Oncotarget","first-page":"112907","article-title":"Genome-wide transcriptional profiling identifies potential signatures in discriminating active tuberculosis from latent infection","volume":"8","author":"Pan","year":"2017"},{"key":"b23","series-title":"J Clin Endocrinol Metab","first-page":"4771","article-title":"Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi","volume":"90","author":"van Lettow","year":"2005"},{"key":"b24","series-title":"Clin Biochem","first-page":"40","article-title":"The role of feed regulating peptides on weight loss in patients with pulmonary tuberculosis","volume":"46","author":"Yurt","year":"2013"},{"key":"b25","series-title":"Int Immunol","first-page":"1399","article-title":"Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob\/ob mice","volume":"17","author":"Wieland","year":"2005"},{"key":"b26","series-title":"Eur Cytokine Netw","first-page":"157","article-title":"Effective treatment of pulmonary tuberculosis restores plasma leptin levels","volume":"24","author":"Perna","year":"2013"},{"key":"b27","series-title":"Endocr Res","first-page":"257","article-title":"The relation between serum leptin levels and body fat mass in patients with active lung tuberculosis","volume":"29","author":"Yuksel","year":"2003"},{"key":"b28","series-title":"Korean J Pediatr","first-page":"118","article-title":"Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children","volume":"60","author":"Mexitalia","year":"2017"}],"container-title":["The American Journal of Tropical Medicine and 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