{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:28:59Z","timestamp":1777134539996,"version":"3.51.4"},"reference-count":40,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,6]]},"abstract":"<jats:p>The aim of our study was to describe the clinical features, the etiologies, and the factors associated with poor outcome of encephalitis in French Guiana. Our study was retrospective, including all cases of encephalitis hospitalized in the Cayenne General Hospital, from January 2007 to July 2017. Patients were included through the 2013 encephalitis consortium criteria and the outcome was evaluated using the Glasgow outcome scale at 3 months from the diagnosis of encephalitis. We included 108 patients, giving an approximate incidence rate of four cases\/100,000 inhabitants\/year. The origin of the encephalitis was diagnosed in 81 cases (75%), and 72 of them (66.7%) were from an infectious origin. The most common infectious causes were <jats:italic>Cryptococcus<\/jats:italic> sp. (18.5%) independently of the immune status, <jats:italic>Toxoplasma gondii<\/jats:italic> (13.9%), and <jats:italic>Streptococcus pneumoniae<\/jats:italic> (5.5%). In the follow-up, 48 patients (46.6%) had poor outcome. Independent risk factors associated with poor outcome at 3 months were \u201ccoming from inside area of the region\u201d (<jats:italic>P<\/jats:italic> = 0.036, odds ratio [OR] = 4.19; CI 95% = 1.09\u201316.06), need for mechanical ventilation (<jats:italic>P<\/jats:italic> = 0.002, OR = 5.92; CI 95% = 1.95\u201317.95), and age \u2265 65 years (<jats:italic>P<\/jats:italic> = 0.049, OR = 3.99; CI 95% = 1.01\u201315.89). The most identified cause of encephalitis in French Guiana was <jats:italic>Cryptococcus<\/jats:italic>. The shape of the local epidemiology highlights the original infectious situation with some local specific pathogens.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0308","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T07:00:43Z","timestamp":1545116443000},"page":"452-459","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Features, Diagnosis, and Outcome of Encephalitis in French Guiana"],"prefix":"10.4269","volume":"100","author":[{"given":"Alexandre","family":"Roux","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Houcke","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Sanna","sequence":"additional","affiliation":[{"name":"Regional Authority of Health, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille","family":"Mathien","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Mayence","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Gueneau","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffroy","family":"Liegeon","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaelle","family":"Walter","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dabor","family":"Resiere","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Fort de France University Hospital, Fort de France, Martinique;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narcisse","family":"Elenga","sequence":"additional","affiliation":[{"name":"Pediatric Unit Cayenne General Hospital, Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9raldine","family":"Resin","sequence":"additional","affiliation":[{"name":"Pediatric Unit Cayenne General Hospital, Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Djossou","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Hommel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Kallel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, Cayenne, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Infect Dis","first-page":"1114","article-title":"Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis 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