{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:29:39Z","timestamp":1778657379081,"version":"3.51.4"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,3]]},"abstract":"<jats:p>Skeletal muscle is known to be damaged by falciparum malaria via sequestration of infected erythrocytes. We present a case of rhabdomyolysis caused by <jats:italic>Plasmodium knowlesi<\/jats:italic> infection. The patient had fever, myalgia, and muscle weakness 5 days after returning to Japan from Palawan, the Philippines. Blood test revealed thrombocytopenia and an elevated creatine kinase level. Although rhabdomyolysis resolved with fluid therapy, fever of 24-hour cycle continued and thrombocytopenia intensified. On day 7 of illness, Giemsa-stained thin blood smear revealed malaria parasites, with a parasite count of 2,380\/\u03bcL, which were morphologically indistinguishable between <jats:italic>P. knowlesi<\/jats:italic> and <jats:italic>Plasmodium malariae<\/jats:italic>. Rapid diagnostic test showed a negative result. The pathogen was later confirmed to be <jats:italic>P. knowlesi<\/jats:italic> by nested polymerase chain reaction (PCR). The patient was successfully treated with artemether\/lumefantrine. This case suggests that knowlesi malaria might be able to cause skeletal muscle damage.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0348","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T07:01:20Z","timestamp":1536130880000},"page":"967-969","source":"Crossref","is-referenced-by-count":11,"title":["Case Report: Plasmodium knowlesi Infection with Rhabdomyolysis in a Japanese Traveler to Palawan, the Philippines"],"prefix":"10.4269","volume":"99","author":[{"given":"Saho","family":"Takaya","sequence":"first","affiliation":[{"name":"Diseases Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kutsuna","sequence":"additional","affiliation":[{"name":"Diseases Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Diseases Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Komaki-Yasuda","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Malaria, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Kano","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Malaria, National Center for Global Health and Medicine Research Institute, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Ohmagari","sequence":"additional","affiliation":[{"name":"Diseases Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Infect Dis","first-page":"831","article-title":"Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study","volume":"29","author":"Davis","year":"1999"},{"key":"b2","series-title":"Acta Trop","first-page":"271","article-title":"Progression of skeletal muscle damage during treatment of severe falciparum malaria","volume":"76","author":"Davis","year":"2000"},{"key":"b3","series-title":"PLoS One","first-page":"e0191886","article-title":"A novel PCR-based system for the detection of four species of human malaria parasites and Plasmodium knowlesi","volume":"13","author":"Komaki-Yasuda","year":"2018"},{"key":"b4","series-title":"Lancet","first-page":"1017","article-title":"A large focus of naturally acquired Plasmodium knowlesi infections in human beings","volume":"363","author":"Singh","year":"2004"},{"key":"b5","series-title":"Clin Microbiol Rev","first-page":"165","article-title":"Human infections and detection of Plasmodium knowlesi","volume":"26","author":"Singh","year":"2013"},{"key":"b6","series-title":"J Infect Dis","first-page":"265","article-title":"A systematic review: performance of rapid diagnostic tests for the detection of Plasmodium knowlesi, Plasmodium malariae, and Plasmodium ovale monoinfections in human blood","volume":"218","author":"Yerlikaya","year":"2018"},{"key":"b7","series-title":"Am J Trop Med Hyg","first-page":"271","article-title":"Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon","volume":"83","author":"Siqueira","year":"2010"},{"key":"b8","series-title":"J Infect Dis","first-page":"475","article-title":"Endothelial cell activation in muscle biopsy samples is related to clinical severity in human cerebral malaria","volume":"179","author":"Garcia","year":"1999"},{"key":"b9","series-title":"Nature","first-page":"57","article-title":"Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum","volume":"341","author":"Berendt","year":"1989"},{"key":"b10","series-title":"J Exp Med","first-page":"1183","article-title":"Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1","volume":"176","author":"Ockenhouse","year":"1992"},{"key":"b11","series-title":"J Infect Dis","first-page":"528","article-title":"Impaired skeletal muscle microvascular function and increased skeletal muscle oxygen consumption in severe falciparum malaria","volume":"207","author":"Yeo","year":"2013"},{"key":"b12","series-title":"Malar J","first-page":"524","article-title":"The effect of malaria and anti-malarial drugs on skeletal and cardiac muscles","volume":"15","author":"Marrelli","year":"2016"},{"key":"b13","series-title":"PLoS Negl Trop Dis","first-page":"e0004915","article-title":"Estimating geographical variation in the risk of zoonotic Plasmodium knowlesi infection in countries eliminating malaria","volume":"10","author":"Shearer","year":"2016"},{"key":"b14","series-title":"Malar J","first-page":"10","article-title":"Severe malaria\u2014a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report","volume":"9","author":"Cox-Singh","year":"2010"},{"key":"b15","series-title":"Malar J","first-page":"33","article-title":"Cytoadherence and virulence\u2014the case of Plasmodium knowlesi malaria","volume":"11","author":"Fatih","year":"2012"}],"container-title":["The American Journal of Tropical Medicine and 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