{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:53:17Z","timestamp":1775832797343,"version":"3.50.1"},"reference-count":12,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,7]]},"abstract":"<jats:p><jats:italic>Bothrops lanceolatus<\/jats:italic> is an endemic <jats:italic>Crotalidae<\/jats:italic> species in Martinique, where approximately 30 cases of envenoming are managed yearly. Envenoming characteristics from <jats:italic>Bothrops<\/jats:italic> species include local tissue damage, systemic bleeding, and hemodynamic alterations. We hereby report a case of severe envenomation following <jats:italic>B. lanceolatus<\/jats:italic> snakebite to the right calf. Severe local manifestations developed progressively up to the lower limb despite adequate antivenom therapy. Systemic manifestations of venom also occurred, resulting in intensive care therapy. Surgery exploration revealed soft tissue necrosis, friability of the deep fascia, and myonecrosis. The patient needed multiple debridement procedures and fasciotomy of all leg compartments and anterior compartment of the thigh. Diagnosis of necrotizing fasciitis was confirmed by positive <jats:italic>Aeromonas hydrophila<\/jats:italic> blood cultures. This clinical case illustrates that major soft tissue infection, including necrotizing fasciitis may occur after snakebite. Abnormal coagulation tests should not delay surgical management, as severe envenoming is a life-threatening condition.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0393","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T07:01:10Z","timestamp":1537254070000},"page":"1350-1353","source":"Crossref","is-referenced-by-count":10,"title":["Case Report: Bothrops lanceolatus Snakebite Surgical Management\u2014Relevance of Fasciotomy"],"prefix":"10.4269","volume":"99","author":[{"given":"M.","family":"Severyns","sequence":"first","affiliation":[{"name":"Orthopaedic and Traumatologic Department, CHU Martinique (University Hospital of Martinique), Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Nevi\u00e8re","sequence":"additional","affiliation":[{"name":"Physiology Department, CHU Martinique (University Hospital of Martinique), Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Resiere","sequence":"additional","affiliation":[{"name":"Critical Care Unit, CHU Martinique (University Hospital of Martinique), Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Andriamananaivo","sequence":"additional","affiliation":[{"name":"Orthopaedic and Traumatologic Department, CHU Martinique (University Hospital of Martinique), Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Decaestecker","sequence":"additional","affiliation":[{"name":"Orthopaedic and Traumatologic Department, CHU Martinique (University Hospital of Martinique), Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mehdaoui","sequence":"additional","affiliation":[{"name":"Critical Care Unit, CHU Martinique (University Hospital of Martinique), Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Odri","sequence":"additional","affiliation":[{"name":"Orthopaedic Department, CHU Lariboisi\u00e8re (University Hospital of Lariboisi\u00e8re), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Rouvillain","sequence":"additional","affiliation":[{"name":"Orthopaedic and Traumatologic Department, CHU Martinique (University Hospital of Martinique), Fort-de-France, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Toxins (Basel)","first-page":"163","article-title":"Bothrops lanceolatus bites: guidelines for severity assessment and emergent management","volume":"2","author":"Resiere","year":"2010"},{"key":"b2","series-title":"Toxins (Basel)","first-page":"244","article-title":"Enzymatic and pro-inflammatory activities of Bothrops lanceolatus venom: relevance for envenomation","volume":"9","author":"Delafontaine","year":"2017"},{"key":"b3","series-title":"Am J Trop Med Hyg","first-page":"419","article-title":"Prevention of thromboses in human patients with Bothrops lanceolatus envenoming in Martinique: failure of anticoagulants and efficacy of a monospecific antivenom. Research Group on Snake Bites in Martinique","volume":"52","author":"Thomas","year":"1995"},{"key":"b4","series-title":"Toxicon","first-page":"371","article-title":"Coagulant and anticoagulant activities of Bothrops lanceolatus (fer de lance) venom","volume":"39","author":"L\u00f4bo de Ara\u00fajo","year":"2001"},{"key":"b5","series-title":"Toxicon","first-page":"745","article-title":"Purification from Bothrops lanceolatus (fer de lance) venom of a fibrino (geno) lytic enzyme with esterolytic activity","volume":"36","author":"L\u00f4bo de Ara\u00fajo","year":"1998"},{"key":"b6","series-title":"J Proteome Res","first-page":"4396","article-title":"Snake venomics of the lesser antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom","volume":"7","author":"Guti\u00e9rrez","year":"2008"},{"key":"b7","series-title":"Toxicon","first-page":"836","article-title":"Proteomic profiling of snake venom metalloproteinases (SVMPs): insights into venom induced pathology","volume":"54","author":"Terra","year":"2009"},{"key":"b8","series-title":"BMC Genomics","article-title":"A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)","volume":"11","author":"Cardoso","year":"2010"},{"key":"b9","series-title":"Toxicon","first-page":"398","article-title":"Osteopontin, a chemotactic protein with cytokine-like properties, is up-regulated in muscle injury caused by Bothrops lanceolatus (fer-de-lance) snake venom","volume":"58","author":"Barbosa-Souza","year":"2011"},{"key":"b10","series-title":"Int J Infect Dis","first-page":"30","article-title":"Necrotizing fasciitis following venomous snakebites in a tertiary hospital of southwest Taiwan","volume":"63","author":"Tsai","year":"2017"},{"key":"b11","series-title":"Inflamm Res","first-page":"284","article-title":"Pharmacological and histopathological characterization of Bothrops lanceolatus (fer de lance) venom-induced edema","volume":"53","author":"Guimar\u00e3es","year":"2004"},{"key":"b12","series-title":"Ann Trop Med Parasitol","first-page":"401","article-title":"Prognostic factors for amputation in the case of envenoming by snakes of the Bothrops genus (Viperidae)","volume":"93","author":"Jorge","year":"1999"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/5\/article-p1350.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/5\/article-p1350.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/99\/5\/article-p1350.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:39:22Z","timestamp":1722433162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/99\/5\/article-p1350.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,7]]},"references-count":12,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0393","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,7]]}}}