{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:00:56Z","timestamp":1783602056839,"version":"3.55.0"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,7]]},"abstract":"<jats:p><jats:italic>Dientamoeba fragilis<\/jats:italic> is an intestinal protozoan, usually considered nonpathogenic. However, in the last years, there has been an attempt to clarify its possible pathogenic role. We aim to evaluate the clinical and epidemiological characteristics of <jats:italic>D. fragilis<\/jats:italic>\u2013infected patients. Adults with <jats:italic>D. fragilis<\/jats:italic> detection in feces who attended the Vall d\u2019Hebron University Hospital (Barcelona, Spain) were evaluated retrospectively from April 2009 to March 2014. We classified the patients in asymptomatic, symptomatic without other causes except infection of <jats:italic>D. fragilis<\/jats:italic>, and symptomatic with another cause. Among symptomatic patients, treatment response was evaluated. One hundred eight patients were included. Sixty-three percent of the patients were immigrants, 29.6% were autochthonous, and 7.4% were travelers. Forty-nine (45.3%) patients presented symptoms, and eosinophilia was observed in 26 (24.1%) patients. Overall, 59 (54.7%) patients were asymptomatic, 15 (13.8%) presented symptoms which were attributable to other causes, and 34 (31.5%) patients presented symptoms with no other causes. In this last group, 29 patients received specific treatment and 65.5% of them presented a complete resolution of the symptoms. The group of symptomatic patients with no other cause had more proportion of women, more proportion of autochthonous people, and were older compared with the group of asymptomatic patients. <jats:italic>Dientamoeba fragilis<\/jats:italic> infection should be considered as pathogenic when other causes are ruled out.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0433","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T07:00:50Z","timestamp":1539846050000},"page":"1170-1173","source":"Crossref","is-referenced-by-count":21,"title":["Clinical and Epidemiological Characteristics of Patients with Dientamoeba fragilis Infection"],"prefix":"10.4269","volume":"99","author":[{"given":"Luc\u00eda","family":"Miguel","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Vall d\u2019Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, PROSICS Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Vall d\u2019Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, PROSICS Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sulleiro","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"S\u00e1nchez-Montalv\u00e1","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Vall d\u2019Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, PROSICS Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Molina-Morant","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Vall d\u2019Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, PROSICS Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Vall d\u2019Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Vall d\u2019Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, PROSICS Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Int J Parasitol","first-page":"793","article-title":"Multilocus sequence typing of Dientamoeba fragilis identified a major clone with widespread geographical distribution","volume":"46","author":"Cacci\u00f2","year":"2016"},{"key":"b2","series-title":"Clin Microbiol Infect","first-page":"65","article-title":"Dientamoeba fragilis a protozoan infection which may cause severe bowel distress","volume":"9","author":"Norberg","year":"2003"},{"key":"b3","series-title":"J Clin Microbiol","first-page":"2680","article-title":"Description of Dientamoeba fragilis cyst and precystic forms from human samples","volume":"52","author":"Stark","year":"2014"},{"key":"b4","series-title":"Br J Biomed Sci","first-page":"172","article-title":"Dientamoeba fragilis: the unflagelated flagellate","volume":"55","author":"Windsor","year":"1998"},{"key":"b5","series-title":"Clin Microbiol Rev","first-page":"553","article-title":"Emerging from obscurity: biological, clinical, and diagnostic aspects of Dientamoeba 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Microbiol","first-page":"2718","article-title":"Prospective study of the prevalence, genotyping, and clinical relevance of Dientamoeba fragilis infections in an Australian population","volume":"43","author":"Stark","year":"2005"},{"key":"b11","series-title":"Int J Parasitol","first-page":"879","article-title":"Cyst formation and faecal\u2013oral transmission of Dientamoeba fragilis\u2013the missing link in the life cycle of an emerging pathogen","volume":"43","author":"Munasinghe","year":"2013"},{"key":"b12","series-title":"Fam Pract","first-page":"25","article-title":"Dientamoeba fragilis colonization is not associated with gastrointestinal symptoms in children at primary care level","volume":"34","author":"Holtman","year":"2017"},{"key":"b13","series-title":"Int J Parasitol Drugs Drug Resist","first-page":"204","article-title":"Current treatment options for Dientamoeba fragilis infections","volume":"2","author":"Nagata","year":"2012"},{"key":"b14","series-title":"J Clin Microbiol","first-page":"2243","article-title":"Dientamoeba fragilis, one of the neglected intestinal protozoa","volume":"54","author":"Garcia","year":"2016"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"1046","article-title":"Treatment of Dientamoeba fragilis in patients with irritable bowel syndrome","volume":"87","author":"Engsbro","year":"2012"}],"container-title":["The American Journal of Tropical Medicine and 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