{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:54:57Z","timestamp":1780401297552,"version":"3.54.1"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,9]]},"abstract":"<jats:p>Self-medication with antimalarial drugs is a major factor in the development of drug resistance, exerting subtherapeutic drug pressure on circulating parasite populations. Data on self-medication with antimalarials from the Southern Pacific coast region of Colombia, where 4-aminoquinolines resistance and political instability prevail, are vital to elimination strategies. We present results of an exploratory study of 254 individuals having malaria symptoms who sought malaria diagnosis in two hospitals in Tumaco, Department of Nari\u00f1o, Colombia. Thirty-two percent (82\/254) of participants had positive Saker\u2013Solomons urine tests, indicating self-medication with chloroquine (CQ) before consultation for diagnosis. Notably, among 30 pregnant women participating in the study, 43% were Saker-\u2013Solomons positive. Molecular analysis of the K76T position encoded by the <jats:italic>pfcrt<\/jats:italic> gene revealed the mutant allele in all four samples that were both positive for <jats:italic>Plasmodium falciparum<\/jats:italic> and positive for the Saker\u2013Solomons test, suggesting persistent CQ pressure. The high frequency of self-medication, particularly among pregnant women merits attention by public health authorities and comprehensive investigation.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0515","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T07:03:52Z","timestamp":1542697432000},"page":"66-71","source":"Crossref","is-referenced-by-count":9,"title":["Evidence of Self-Medication with Chloroquine before Consultation for Malaria in the Southern Pacific Coast Region of Colombia"],"prefix":"10.4269","volume":"100","author":[{"given":"Gustavo","family":"Diaz","sequence":"first","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"},{"name":"Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro Mauricio","family":"Lasso","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claribel","family":"Murillo","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia M.","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego F.","family":"Echeverry","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia;"},{"name":"Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Mem Inst Oswaldo Cruz","first-page":"559","article-title":"Assessment of therapeutic response of 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Estad\u00edstica (DANE)","year":"2012"},{"key":"b19","series-title":"Rev Salud Publica","first-page":"45","article-title":"Proportion of fever attributable to malaria in Colombia: potential indicators for monitoring progress towards malaria elimination","volume":"19","author":"Valero-Bernal","year":"2017"},{"key":"b20","series-title":"Bull World Health Organ","first-page":"295","article-title":"Adaptations of the Saker-Solomons test: simple, reliable colorimetric field assays for chloroquine and its metabolites in urine","volume":"67","author":"Mount","year":"1989"},{"key":"b21","series-title":"Mol Cel Probes","first-page":"100","article-title":"Multiplex PCR-RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum","volume":"20","author":"Veiga","year":"2006"},{"key":"b22","series-title":"Revista Brasileira de Epidemiologia","first-page":"283","article-title":"Epidemiologia de la malaria falciparum complicada: estudio de casos y controles en Tumaco y Turbo, 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