{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:35:33Z","timestamp":1789792533142,"version":"4.0.1"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,7]]},"abstract":"<jats:p><jats:italic>Dipylidium caninum<\/jats:italic> is a cosmopolitan cestode infecting dogs, cats, and humans. Praziquantel is a highly effective cestocidal drug and resistance in adult cestodes has not been reported. From 2016 to 2018, a population of dogs with cestode infections that could not be eliminated despite multiple treatments with praziquantel or epsiprantel was identified. Cases of <jats:italic>D. caninum<\/jats:italic> were clinically resistant to praziquantel and could not be resolved despite increasing the dose, frequency, and duration of treatment. Resistant isolates were identified and characterized by sequencing the 28S, 12S, and voltage-gated calcium channel beta subunit genes. Cases were only resolved following treatment with nitroscanate or a compounded pyrantel\/praziquantel\/oxantel product. Clinicians should be aware of this alarming development as treatment options for cestodes are limited in both human and veterinary medicine.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0533","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T07:01:12Z","timestamp":1537254072000},"page":"1201-1205","source":"Crossref","is-referenced-by-count":66,"title":["Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum"],"prefix":"10.4269","volume":"99","author":[{"given":"Jeba","family":"Jesudoss Chelladurai","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, Iowa State University College of Veterinary Medicine, Ames, Iowa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsegabirhan","family":"Kifleyohannes","sequence":"additional","affiliation":[{"name":"Mekelle University College of Veterinary Medicine, Mekelle, Ethiopia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Brewer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Iowa State University College of Veterinary Medicine, Ames, Iowa;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Vet Parasitol","first-page":"153","article-title":"Endoparasite prevalence and recurrence across different age groups of dogs and cats","volume":"166","author":"Gates","year":"2009"},{"key":"b2","series-title":"Parasitol Res","first-page":"171","article-title":"Effects on the development of Dipylidium caninum and on the host reaction to this parasite in the adult flea (Ctenocephalides felis felis)","volume":"73","author":"Pugh","year":"1987"},{"key":"b3","series-title":"Zeitschrift f\u00fcr Parasitenkunde","first-page":"717","article-title":"Life-history studies on cestodes of the genus dipylidium from the dog","volume":"9","author":"Zimmermann","year":"1937"},{"key":"b4","series-title":"Vet Parasitol","first-page":"102","article-title":"Pathogens in ectoparasites from free-ranging animals: infection with Rickettsia asembonensis in ticks, and a potentially new species of Dipylidium in fleas and lice","volume":"245","author":"Low","year":"2017"},{"key":"b5","series-title":"Turkiye Parazitol Derg","first-page":"17","article-title":"Efficacy of praziquantel injectable solution against feline and canine tapeworms","volume":"34","author":"T\u00fczer","year":"2010"},{"key":"b6","series-title":"Br Vet J","first-page":"384","article-title":"Epsiprantel, a new tapeworm remedy. 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