{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:39:49Z","timestamp":1789115989431,"version":"build-2803163510"},"reference-count":29,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,5]]},"abstract":"<jats:p>The sensitivity of a point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for diagnosis of <jats:italic>Schistosoma mansoni<\/jats:italic> in low-endemicity settings is poorly understood. We conducted a cross-sectional survey in 14 villages in western C\u00f4te d\u2019Ivoire and diagnosed children aged 9\u201312 years for schistosomiasis. Two stool samples were subjected to triplicate Kato\u2013Katz thick smears each for diagnosis of <jats:italic>S. mansoni<\/jats:italic>, whereas a single urine sample was examined by POC-CCA for <jats:italic>S. mansoni,<\/jats:italic> filtration for <jats:italic>Schistosoma haematobium,<\/jats:italic> and reagent strip for microhematuria. According to the Kato\u2013Katz technique, we found 45 out of 681 children positive for <jats:italic>S. mansoni<\/jats:italic> (6.6%) with a mean intensity among infected children of 72.2 eggs per gram of stool. Point-of-care circulating cathodic antigen revealed a prevalence of <jats:italic>S. mansoni<\/jats:italic> of 33.0% when trace results were considered positive and 12.5% when trace results were considered negative. Eggs of <jats:italic>S. haematobium<\/jats:italic> were found in eight participants (1.2%), whereas the prevalence of microhematuria was 13.5%. A single POC-CCA urine cassette test revealed a several-fold higher prevalence of <jats:italic>S. mansoni<\/jats:italic> than multiple Kato\u2013Katz thick smears in this low-endemicity area. Our findings have important ramifications for choosing an appropriate diagnostic tool in low-endemic areas that might be targeted for elimination.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0550","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T07:00:28Z","timestamp":1538463628000},"page":"1567-1572","source":"Crossref","is-referenced-by-count":20,"title":["Sensitivity of the Point-of-Care Circulating Cathodic Antigen Urine Cassette Test for Diagnosis of Schistosoma mansoni in Low-Endemicity Settings in C\u00f4te d\u2019Ivoire"],"prefix":"10.4269","volume":"99","author":[{"given":"Rufin K.","family":"Assar\u00e9","sequence":"first","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"University of Basel, Basel, Switzerland;"},{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d'Ivoire;"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu B. I.","family":"Tra","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d'Ivoire;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Ouattara","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d'Ivoire;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"H\u00fcrlimann","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"University of Basel, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean T.","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"University of Basel, Basel, Switzerland;"},{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d'Ivoire;"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli\u00e9zer K.","family":"N\u2019Goran","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d'Ivoire;"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"University of Basel, Basel, 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