{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:45:40Z","timestamp":1757702740387},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,5]]},"abstract":"<jats:p>At the end phase of the Global Programme to Eliminate Lymphatic Filariasis, antibody testing may have a role in decision-making for bancroftian filariasis\u2013endemic areas. This study evaluated the diagnostic performance of BLF Rapid<jats:sup>\u2122<\/jats:sup>, a prototype immunochromatographic IgG4-based test using <jats:italic>Bm<\/jats:italic>SXP recombinant protein, for detection of bancroftian filariasis. The test was evaluated using 258 serum samples, comprising 96 samples tested at Universiti Sains Malaysia (in-house) and 162 samples tested independently at three international laboratories in the USA and India, and two laboratories in Malaysia. The independent testing involved 99 samples from <jats:italic>Wuchereria bancrofti<\/jats:italic> microfilaria or antigen positive individuals and 63 samples from people who were healthy or had other infections. The in-house evaluation showed 100% diagnostic sensitivity and specificity. The independent evaluations showed a diagnostic sensitivity of 84\u2013100% and 100% specificity (excluding non-lymphatic filarial infections). BLF Rapid has potential as a surveillance diagnostic tool to make \u201cTransmission Assessment Survey\u201d\u2013stopping decisions and conduct post-elimination surveillance.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0566","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:01:06Z","timestamp":1540278066000},"page":"1587-1590","source":"Crossref","is-referenced-by-count":9,"title":["Laboratory Evaluation of a Rapid IgG4 Antibody Test (BLF Rapid\u2122) for Bancroftian Filariasis"],"prefix":"10.4269","volume":"99","author":[{"given":"Rahmah","family":"Noordin","sequence":"first","affiliation":[{"name":"Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Hafiznur","family":"Yunus","sequence":"additional","affiliation":[{"name":"Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keri","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly Y.","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash","family":"Babu","sequence":"additional","affiliation":[{"name":"National Institutes of Health-International Center for Excellence in Research, National Institute of Research in Tuberculosis, Chennai, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter U.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamilah","family":"Hisam","sequence":"additional","affiliation":[{"name":"Parasitology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohela","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Wkly Epidemiol Rec","first-page":"594","article-title":"Global programme to eliminate lymphatic filariasis: progress report, 2016","volume":"92","author":"WHO","year":"2017"},{"key":"b2","series-title":"Korean J Parasitol","first-page":"119","article-title":"Clinical and pathological aspects of filarial lymphedema and its management","volume":"46","author":"Shenoy","year":"2008"},{"key":"b3","series-title":"Lancet","first-page":"1260","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132013; 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