{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:46Z","timestamp":1790834626525,"version":"4.1.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:p>Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a common genetic blood condition, can result in kernicterus at birth, and later in life as severe hemolysis on exposure to certain infections, foods, and drugs. The unavailability of point-of-care tests for G6PD deficiency is a barrier to routine curative treatment of <jats:italic>Plasmodium vivax<\/jats:italic> malaria with 8-aminoquinolines, such as primaquine. Two quantitative reference tests (Trinity Biotech, Bray, Ireland and Pointe Scientific, Canton, MI; Cat No. G7583) and the point-of-care STANDARD<jats:sup>\u2122<\/jats:sup> G6PD test (SD Biosensor, Suwon, South Korea) were evaluated. The STANDARD G6PD test was evaluated at multiple temperatures, in anticoagulated venous and capillary samples, including 79 G6PD-deficient and 66 intermediate samples and across two laboratories, one in the United States and one in Thailand. The STANDARD test performed equivalently to a reference assay for its ability to diagnose G6PD deficiency (&lt; 30% normal) with a sensitivity of 100% (0.95 confidence interval [CI]: 95.7\u2013100) and specificity of 97% (0.95 CI: 94.5\u201398.5), and could reliably identify females with less than 70% normal G6PD activity with a sensitivity of 95.5% (0.95 CI: 89.7\u201398.5) and specificity of 97% (0.95 CI: 94.5\u201398.6). The STANDARD G6PD product represents an opportunity to diagnose G6PD deficiency equally for males and females in basic clinical laboratories in high- and low-resource settings. This quantitative point-of-care diagnostic test for G6PD deficiency can provide equal access to safe radical cure of <jats:italic>P. vivax<\/jats:italic> cases in high- and low-resource settings, for males and females and may support malaria elimination, in countries where <jats:italic>P. vivax<\/jats:italic> is endemic.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0612","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:01:04Z","timestamp":1540278064000},"page":"213-221","source":"Crossref","is-referenced-by-count":91,"title":["Evaluation of a Novel Quantitative Test for Glucose-6-Phosphate Dehydrogenase Deficiency: Bringing Quantitative Testing for Glucose-6-Phosphate Dehydrogenase Deficiency Closer to the Patient"],"prefix":"10.4269","volume":"100","author":[{"given":"Sampa","family":"Pal","sequence":"first","affiliation":[{"name":"Diagnostics Program, PATH, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Bansil","sequence":"additional","affiliation":[{"name":"Diagnostics Program, PATH, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germana","family":"Bancone","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol\u2013Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevan","family":"Hrutkay","sequence":"additional","affiliation":[{"name":"Diagnostics Program, PATH, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kahn","sequence":"additional","affiliation":[{"name":"Diagnostics Program, PATH, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gornpan","family":"Gornsawun","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol\u2013Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimsupah","family":"Penpitchaporn","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol\u2013Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy S.","family":"Chu","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol\u2013Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Nosten","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mahidol\u2013Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo J.","family":"Domingo","sequence":"additional","affiliation":[{"name":"Diagnostics Program, PATH, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Hematol Oncol Clin North Am","first-page":"373","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"30","author":"Luzzatto","year":"2016"},{"key":"b2","series-title":"Blood Cells Mol 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