{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:45:54Z","timestamp":1791265554403,"version":"4.1.0"},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,9]]},"abstract":"<jats:p>Zika virus (ZIKV) infection is an emerging public health problem, associated with increased risk for Guillain\u2013Barr\u00e9 syndrome and adverse fetal outcomes, including congenital microcephaly. Zika virus sexual transmission is known, but detection of the virus in different parts of the female reproductive tract is not well established. In this case report, we describe prolonged detection of ZIKV RNA in the vaginal secretion and endocervical mucosa from a Brazilian woman convalescent to ZIKV infection. A viral load of 2 \u00d7 10<jats:sup>2<\/jats:sup> copies\/mL was detected up to 31 days after symptom onset in both samples. Other biological fluids, including whole blood, plasma, serum, urine, and saliva samples, were negative for ZIKV RNA. These findings advance the understanding of ZIKV infection and provide data for additional testing strategies.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0623","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T07:00:29Z","timestamp":1541487629000},"page":"183-186","source":"Crossref","is-referenced-by-count":10,"title":["Case Reports: Prolonged Detection of Zika Virus RNA in Vaginal and Endocervical Samples from a Brazilian Woman, 2018"],"prefix":"10.4269","volume":"100","author":[{"given":"Ta\u00eds E.","family":"da Cruz","sequence":"first","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel P.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra M.","family":"Pelloso","sequence":"additional","affiliation":[{"name":"Department of Nursing, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamy T.","family":"Suehiro","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilson","family":"Damke","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia de S.","family":"Bonfim-Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia R. S.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia E. L.","family":"Consolaro","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Paran\u00e1, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Microbiol","first-page":"204","article-title":"Zika virus: an emerging Flavivirus","volume":"55","author":"Yun","year":"2017"},{"key":"b2","series-title":"Emerg Infect Dis","first-page":"880","article-title":"Probable non\u2013vectorborne transmission of Zika virus, Colorado, USA","volume":"17","author":"Foy","year":"2011"},{"key":"b3","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"372","article-title":"Male-to-male sexual transmission of Zika virus\u2013Texas, January 2016","volume":"65","author":"Deckard","year":"2016"},{"key":"b4","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"716","article-title":"Suspected female-to-male sexual transmission of Zika virus\u2014New York City, 2016","volume":"65","author":"Davidson","year":"2016"},{"key":"b5","series-title":"Clin Infect Dis","first-page":"211","article-title":"Male-to-female sexual transmission of Zika virus-United States, January\u2013April 2016","volume":"64","author":"Russell","year":"2017"},{"key":"b6","series-title":"Semin Reprod Med","first-page":"299","article-title":"Vaccine development for Zika virus-timelines and strategies","volume":"34","author":"Durbin","year":"2016"},{"key":"b7","series-title":"Acta Cytolog","first-page":"359","article-title":"The Bethesda System for reporting cervical cytology: a historical perspective","volume":"61","author":"Nayar","year":"2017"},{"key":"b8","series-title":"J Clin Virol","first-page":"56","article-title":"Zika virus epidemic in Brazil. I. Fatal disease in adults: clinical and laboratorial aspects","volume":"85","author":"Azevedo","year":"2016"},{"key":"b9","series-title":"Sci Rep","first-page":"1","article-title":"In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus","volume":"8","author":"Azevedo","year":"2018"},{"key":"b10","series-title":"Euro Surveill","first-page":"30261","article-title":"Confirmed case of Zika virus congenital infection, Spain, March 2016","volume":"21","author":"Perez","year":"2016"},{"key":"b11","series-title":"Clin Microbiol Infect","first-page":"296","article-title":"Sexually acquired Zika virus: a systematic review","volume":"23","author":"Moreira","year":"2017"},{"key":"b12","series-title":"Emerg Infect Dis","first-page":"99","article-title":"Prolonged detection of Zika virus in vaginal secretions and whole blood","volume":"23","author":"Murray","year":"2017"},{"key":"b13","series-title":"Euro Surveill","first-page":"30314","article-title":"Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016","volume":"21","author":"Nicastri","year":"2016"},{"key":"b14","series-title":"Lancet Infect Dis","first-page":"771","article-title":"Diagnosis of Zika virus infection in pregnant women travelling to or residing in endemic areas","volume":"16","author":"Nicastri","year":"2016"},{"key":"b15","series-title":"Lancet Infect Dis","first-page":"1107","article-title":"Zika virus infection in semen: effect on human reproduction","volume":"17","author":"Barzon","year":"2017"},{"key":"b16","series-title":"Euro Surveill","first-page":"30444","article-title":"Infectious Zika virus in vaginal secretions from HIV-infected woman, France, August 2016","volume":"22","author":"Penot","year":"2017"},{"key":"b17","series-title":"Lancet Infect Dis","first-page":"1000","article-title":"Zika virus in the female genital tract","volume":"16","author":"Prisant","year":"2016"},{"key":"b18","series-title":"Emerg Infect Dis","first-page":"1855","article-title":"Sexual transmission of Zika virus and persistence in semen, New Zealand, 2016","volume":"22","author":"Harrower","year":"2016"},{"key":"b19","series-title":"Clin Infect Dis","first-page":"1264","article-title":"Long-lasting persistence of Zika virus in semen","volume":"63","author":"Matheron","year":"2016"},{"key":"b20","series-title":"Emerg Infect Dis","first-page":"137","article-title":"Persistent Zika virus detection in semen in a traveler returning to the United Kingdom from Brazil, 2016","volume":"23","author":"Gaskell","year":"2017"},{"key":"b21","series-title":"Euro Surveill","first-page":"30316","article-title":"Infection dynamics in a traveller with persistent shedding of Zika virus RNA in semen for six months after returning from Haiti to Italy, January 2016","volume":"21","author":"Barzon","year":"2016"},{"key":"b22","series-title":"Emerg Infect Dis","first-page":"611","article-title":"Presence and persistence of Zika virus RNA in semen, United Kingdom, 2016","volume":"23","author":"Atkinson","year":"2017"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/1\/article-p183.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/1\/article-p183.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/1\/article-p183.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:40:28Z","timestamp":1722426028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/1\/article-p183.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,9]]},"references-count":22,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0623","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,9]]}}}