{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:56:58Z","timestamp":1787972218656,"version":"build-2784847793"},"reference-count":42,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,6]]},"abstract":"<jats:p>From April to September 2017, Bangladesh experienced a huge outbreak of acute Chikungunya virus infection in Dhaka. This series describes the clinical and laboratory features of a large number of cases (690; 399 confirmed and 291 probable) suffered during that period. This observational study was carried out at Dhaka Medical College Hospital, Bangladesh. The median age of the patients at presentation was 38 years (IQR 30\u201350) with a male (57.3%) predominance. Hypertension and diabetes were the most common comorbidities. The mean (\u00b1SD) duration of fever was 3.7 (\u00b11.4) days. Other common manifestations were arthralgia (99.2%), maculopapular rash (50.2%), morning stiffness (49.7%), joint swelling (48.5%), and headache (37.6%). Cases were confirmed by anti-chikungunya IgG (173; 43.3%), IgM (165; 42.3%), and reverse transcription polymerase chain reaction (44; 11.0%). Important laboratory findings include high erythrocyte sedimentation rate (156; 22.6%), raised serum glutamic pyruvic transaminase (73; 10.5%), random blood sugar (54; 7.8%), leukopenia (72; 10.4%), thrombocytopenia (41; 5.9%), and others. The oligo-articular (453; 66.1%) variety of joint involvement was significantly more common compared with the poly-articular (237; 34.5%) variety. Commonly involved joints were the wrist (371; 54.1%), small joints of the hand (321; 46.8%), ankle (251; 36.6%), knee (240; 35.0%), and elbow (228; 33.2%). Eleven cases were found to be complicated with neurological involvement and two of them died. Another patient died due to myocarditis. Public health experts, clinicians, and policymakers could use the results of this study to construct the future strategy tackling chikungunya in Bangladesh and other epidemic countries.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0636","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T07:01:00Z","timestamp":1544511660000},"page":"405-410","source":"Crossref","is-referenced-by-count":22,"title":["Clinical and Laboratory Characteristics of an Acute Chikungunya Outbreak in Bangladesh in 2017"],"prefix":"10.4269","volume":"100","author":[{"given":"Md. Mujibur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK. Jakaria","family":"Been Sayed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Moniruzzaman","sequence":"additional","affiliation":[{"name":"Director General of Health Services, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K. M. Humayon","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Uzzwal","family":"Mallik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"},{"name":"Director General of Health Services, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Rockyb","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Bakar","family":"Siddique","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Arman","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazim","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mehedi","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dhaka Medical College, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazle Rabbi","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom;"},{"name":"Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand;"},{"name":"Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Am J Trop Med Hyg","first-page":"916","article-title":"Clinical manifestations associated with peripheral joint involvement in patients with acute chikungunya virus infection","volume":"96","author":"Arroyo-Avila","year":"2017"},{"key":"b2","series-title":"Lancet Infect Dis","first-page":"1118","article-title":"The 2017 Dhaka chikungunya outbreak","volume":"17","author":"Kabir","year":"2017"},{"key":"b3","series-title":"Trans R Soc Trop Med Hyg","first-page":"33","article-title":"An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. 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