{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T21:57:52Z","timestamp":1781992672350,"version":"3.54.5"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,6]]},"abstract":"<jats:p>Cholangiocarcinoma (CCA) is a cancer with high mortality owing to its aggressiveness and resistance to therapy. The liver flukes of the Opisthorchiidae family have been recognized as risk factors of CCA. <jats:italic>Opisthorchis felineus<\/jats:italic> infection occurs in Western Siberia, the biggest endemic area in the Russian Federation, and is associated with chronic inflammation of the bile ducts, which may be linked to severe hepatobiliary morbidity. We report two cases of confirmed CCA who had a chronic <jats:italic>O. felineus<\/jats:italic> infection. Both cases presented unspecific symptoms at the onset of the disease, a stage when severe pathological changes already had occurred. Both patients were living in endemic areas but did not receive any antihelminthic treatment. This report underlines the need for assessment of <jats:italic>O. felineus<\/jats:italic> infection as a causative factor of CCA. The results will provide further arguments for control of <jats:italic>O. felineus<\/jats:italic> in the Russian Federation.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0652","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T07:01:01Z","timestamp":1545894061000},"page":"599-603","source":"Crossref","is-referenced-by-count":20,"title":["Case Report: Two Cases of Cholangiocarcinoma in Patients with Opisthorchis felineus Infection in Western Siberia, Russian Federation"],"prefix":"10.4269","volume":"100","author":[{"given":"Yulia V.","family":"Kovshirina","sequence":"first","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S.","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Vtorushin","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Kovshirina","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav D.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey V.","family":"Chizhikov","sequence":"additional","affiliation":[{"name":"Budget Institution of Higher Education of Khanty-Mansiysk Autonomous Okrug, Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Onishchenko","sequence":"additional","affiliation":[{"name":"Budget Institution of Higher Education of Khanty-Mansiysk Autonomous Okrug, Surgut State University, Surgut, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila M.","family":"Ogorodova","sequence":"additional","affiliation":[{"name":"Federal State Budget Educational Institution of Higher Education, Siberian State Medical University, Ministry of Healthcare of Russian Federation, Tomsk, Russian Federation;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Odermatt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Hepatol","first-page":"1268","article-title":"Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma","volume":"60","author":"Bridgewater","year":"2014"},{"key":"b2","series-title":"Transl Gastrointest Cancer","first-page":"21","article-title":"Cholangiocarcinoma: epidemiology and risk factors","volume":"1","author":"Bragazzi","year":"2012"},{"key":"b3","series-title":"IARC Sci Publ","first-page":"1","article-title":"Cancer incidence in five continents. 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