{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:49:33Z","timestamp":1771652973775,"version":"3.50.1"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Hyperreactive malarial splenomegaly syndrome (HMSS) is a rare cause of splenomegaly in the Western world. Hyperreactive malarial splenomegaly syndrome is caused by an aberrant immunological response to chronic malaria exposure in endemic areas. Revised Fakunle\u2019s criteria may be helpful for diagnosis: persistent splenomegaly (&gt; 10 cm below the costal margin), increased anti-<jats:italic>Plasmodium<\/jats:italic> antibodies, increased IgM levels, exclusion of other causes of splenomegaly or malignancy, and a favorable response to antimalarial treatment. We describe the case of a 16-year-old patient, who recently arrived in Belgium from Guinea with a history of splenomegaly and B symptoms in whom HMSS diagnosis was achieved, thanks to the loop-mediated isothermal amplification method. To our knowledge, this is also the first described case treated by dihydroartemisinin\/piperaquine.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0765","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T07:01:12Z","timestamp":1552374072000},"page":"1187-1190","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Hyperreactive Malarial Splenomegaly Syndrome Diagnosed with Loop-Mediated Isothermal Amplification and Treated with Artemisinin-Based Combination Therapy"],"prefix":"10.4269","volume":"100","author":[{"given":"Francesco G.","family":"Genderini","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Centre Hospitalier Universitaire (CHU) Saint-Pierre, Brussels, Belgium;"},{"name":"Infectious Diseases, Department of Mental and Physical Health and Preventive Medicine, Universit\u00e0 della Campania \u201cLuigi Vanvitelli,\u201d Naples, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Haeseleer","sequence":"additional","affiliation":[{"name":"Hematology Department, Laboratoire Hospitalier Universitaire de Bruxelles - Universit\u00e9 Libre de Bruxelles, CHU Saint-Pierre, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Cantinieaux","sequence":"additional","affiliation":[{"name":"Hematology Department, Laboratoire Hospitalier Universitaire de Bruxelles - Universit\u00e9 Libre de Bruxelles, CHU Saint-Pierre, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Martin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Centre Hospitalier Universitaire (CHU) Saint-Pierre, Brussels, Belgium;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"P N G Med J","first-page":"277","article-title":"HLA heterozygosity and hyperreactive malarious splenomegaly in the Upper Watut Valley of Papua New Guinea","volume":"32","author":"Bhatia","year":"1989"},{"key":"b2","series-title":"Clin Exp Immunol","first-page":"55","article-title":"Cryoglobulinaemia and circulating immune complexes in tropical splenomegaly syndrome","volume":"31","author":"Fakunle","year":"1978"},{"key":"b3","series-title":"Malar J","first-page":"230","article-title":"Chronic malaria and hyper-reactive malarial splenomegaly: a retrospective study on the largest series observed in a non-endemic country","volume":"15","author":"Bisoffi","year":"2016"},{"key":"b4","series-title":"Trop Med Int Health","first-page":"607","article-title":"Hyperreactive malaria in expatriates retourning from sub-Saharan Africa","volume":"5","author":"Van den Ende","year":"2000"},{"key":"b5","series-title":"Am J Trop Med Hyg","first-page":"573","article-title":"Hyperreactive malarial splenomegaly syndrome\u2013can the diagnostic criteria be improved?","volume":"93","author":"McGregor","year":"2015"},{"key":"b6","series-title":"Infection","first-page":"167","article-title":"A case of hyper-reactive malarial splenomegaly. 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Part 1: tropical Africa","volume":"10","author":"Fakunle","year":"1981"},{"key":"b12","series-title":"Lancet","first-page":"1178","article-title":"Review of diagnostic criteria of hyper-reactive malarial splenomegaly","volume":"349","author":"Bates","year":"1997"},{"key":"b13","series-title":"Trans R Soc Trop Med Hyg","first-page":"419","article-title":"Mortality in tropical splenomegaly syndrome","volume":"74","author":"Fakunle","year":"1980"},{"key":"b14","series-title":"Malar J","first-page":"185","article-title":"The hyper-reactive malarial splenomegaly: a systematic review of the literature","volume":"14","author":"Leoni","year":"2015"},{"key":"b15","series-title":"Med Mal Inf","first-page":"29","article-title":"Hyperreactive malarial splenomegaly: three clinical cases and literature review","volume":"39","author":"Camara","year":"2009"},{"key":"b16","series-title":"Acta Clinica Belgica","first-page":"225","article-title":"A 75-years -old missionary with fever, splenomegaly and pancytopenia","volume":"68","author":"Masfrancx","year":"2013"},{"key":"b17","series-title":"Lancet","first-page":"1311","article-title":"Protective effects of the sickle cell gene against malaria morbidity and mortality","volume":"359","author":"Aidoo","year":"2002"},{"key":"b18","series-title":"Blood","first-page":"4415","article-title":"Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa","volume":"106","author":"De Franceschi","year":"2005"},{"key":"b19","series-title":"Am J Trop Med Hyg","first-page":"239","article-title":"Case report: hyper-reactive malarial splenomegaly in a patient with human immunodeficiency virus","volume":"78","author":"De Iaco","year":"2008"},{"key":"b20","series-title":"J Travel Med","first-page":"322","article-title":"Hyperreactive malarial splenomegaly in Europeans: report of five cases","volume":"8","author":"Puente","year":"2001"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/5\/article-p1187.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/5\/article-p1187.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/5\/article-p1187.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T14:22:03Z","timestamp":1722435723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/5\/article-p1187.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":20,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0765","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,1]]}}}