{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:01:49Z","timestamp":1758272509332},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Data regarding cardiac involvement in enteric fever among travelers are scarce. In this retrospective study, 59 patients were hospitalized with enteric fever during 2004\u20132017 and 28 had cardiac workups. Among those, four had evidence of cardiac involvement, including clinical myocarditis, electrocardiogram changes, or troponin elevation. Cardiac involvement was higher among patients infected with <jats:italic>Salmonella<\/jats:italic> Typhi than with <jats:italic>Salmonella<\/jats:italic> Paratyphi A (<jats:italic>P<\/jats:italic> = 0.08), with a significant relative risk of 6 (95% CI: 1.15\u201331.22, <jats:italic>P<\/jats:italic> = 0.03). Time from symptoms onset to effective treatment was longer for patients with cardiac involvement (13 versus 7.15 days, <jats:italic>P<\/jats:italic> &lt; 0.05). It seems that cardiac involvement in enteric fever is not uncommon in travelers. Such involvement seems to be more common in patients with delay of effective treatment to the second week of illness. Although fatal or complicated cases are rare in travelers, the cardiac complication may be an important contributor to morbidity and mortality in this group.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0775","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T07:01:28Z","timestamp":1552374088000},"page":"1098-1100","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac Involvement in Travelers with Enteric Fever"],"prefix":"10.4269","volume":"100","author":[{"given":"Asaf","family":"Biber","sequence":"first","affiliation":[{"name":"The Center for Geographic Medicine and Tropical Diseases, The Chaim Sheba Medical Center, Ramat Gan, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Nof","sequence":"additional","affiliation":[{"name":"Leviev Heart Center, The Chaim Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Schwartz","sequence":"additional","affiliation":[{"name":"The Center for Geographic Medicine and Tropical Diseases, The Chaim Sheba Medical Center, Ramat Gan, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Infect Dis","first-page":"359","article-title":"A large outbreak of Salmonella Paratyphi A infection among Israeli travelers to Nepal","volume":"58","author":"Meltzer","year":"2014"},{"key":"b2","series-title":"Indian J Med Sci","first-page":"28","article-title":"Myocarditis in enteric fever","volume":"49","author":"Prabha","year":"1995"},{"key":"b3","series-title":"Br Heart J","first-page":"145","article-title":"Electrocardiographic study of typhoid myocarditis","volume":"9","author":"Mainzer","year":"1947"},{"key":"b4","series-title":"Lancet Infect Dis","first-page":"341","article-title":"Problem pathogens: extra-intestinal complications of Salmonella enterica serotype Typhi infection","volume":"5","author":"Huang","year":"2005"},{"key":"b5","series-title":"J Travel Med","article-title":"Encephalitis in a traveller with typhoid fever: efficacy of corticosteroids","volume":"24","author":"Mellon","year":"2017"},{"key":"b6","series-title":"Eur Heart J","first-page":"2636","article-title":"Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"34","author":"Caforio","year":"2013"},{"key":"b7","series-title":"J Travel Med","first-page":"329","article-title":"Near-fatal myocarditis complicating typhoid fever in a traveler returning from Nepal","volume":"20","author":"Palombo","year":"2013"},{"key":"b8","series-title":"Lancet Infect Dis","first-page":"623","article-title":"Typhoid and paratyphoid fever in travellers","volume":"5","author":"Connor","year":"2005"},{"key":"b9","series-title":"J Travel Med","article-title":"Infectious disease following travel to developed regions: a snapshot of presentations to an Australian travel medicine clinic","volume":"23","author":"Drewett","year":"2016"},{"key":"b10","series-title":"JAMA","first-page":"2668","article-title":"Laboratory-based surveillance of Salmonella serotype Typhi infections in the United States: antimicrobial resistance on the rise","volume":"283","author":"Ackers","year":"2000"},{"key":"b11","series-title":"Voen Med Zh","first-page":"49","article-title":"Complications and the proximate causes of death in typhoid [in Russian]","author":"Bobin","year":"1993"},{"key":"b12","series-title":"Mil Med Res","first-page":"30","article-title":"Pathophysiology of sepsis-induced myocardial dysfunction","volume":"3","author":"Lv","year":"2016"},{"key":"b13","series-title":"Chest","first-page":"1349","article-title":"Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides","volume":"129","author":"Maeder","year":"2006"},{"key":"b14","series-title":"Chest","first-page":"1055","article-title":"Serum cardiac troponin T as a prognostic marker in early sepsis","volume":"113","author":"Spies","year":"1998"},{"key":"b15","series-title":"J Travel Med","first-page":"165","article-title":"Clinical importance of Salmonella Paratyphi A infection to enteric fever in Nepal","volume":"2","author":"Shlim","year":"1995"},{"key":"b16","series-title":"J Travel Med","first-page":"275","article-title":"Enteric fever in Israeli travelers: a nationwide study","volume":"12","author":"Meltzer","year":"2005"},{"key":"b17","series-title":"Trans R Soc Trop Med Hyg","first-page":"440","article-title":"Identification of typhoid fever and paratyphoid fever cases at presentation in outpatient clinics in Jakarta, Indonesia","volume":"99","author":"Vollaard","year":"2005"},{"key":"b18","series-title":"Lancet","first-page":"1136","article-title":"Typhoid fever","volume":"385","author":"Wain","year":"2015"},{"key":"b19","series-title":"PLoS Negl Trop Dis","first-page":"e0006380","article-title":"Open label comparative trial of mono versus dual antibiotic therapy for typhoid fever in adults","volume":"12","author":"Zmora","year":"2018"},{"key":"b20","series-title":"J Antimicrob Chemother","first-page":"313","article-title":"Comparative efficacies of azithromycin and ciprofloxacin against experimental Salmonella typhimurium infection in mice","volume":"31","author":"Butler","year":"1993"},{"key":"b21","series-title":"J Travel Med","first-page":"tav032","article-title":"Azithromycin and ceftriaxone combination treatment for relapsed Salmonella Paratyphi A bacteraemia","volume":"23","author":"Oey","year":"2016"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/5\/article-p1098.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/5\/article-p1098.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/5\/article-p1098.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T14:13:50Z","timestamp":1722435230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/5\/article-p1098.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":21,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0775","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2019,5,1]]}}}