{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:17:10Z","timestamp":1770488230379,"version":"3.49.0"},"reference-count":40,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Eastern equine encephalitis virus (EEEV) infection results in high mortality in infected horses and humans. Florida has been identified as an important source of EEEV epidemics to other states in the United States. In this study, we further characterized the epidemiological and evolutionary dynamics of EEEV in Florida. Epidemiological analysis of sentinel chicken seroconversion rates to EEEV infections during 2005\u20132016 suggested significant seasonality of EEEV activity in Florida. We observed significant annual activity of EEEV in the North and North Central regions, with little significant seasonality in the Panhandle region. Phylogenetic analysis of complete EEEV genome sequences from different host sources and regions in Florida during 1986\u20132014 revealed extensive genetic diversity and spatial dispersal of the virus within Florida and relatively more clustering of the viruses in the Panhandle region. We found no significant association between EEEV genetic variation and host source. Overall, our study revealed a complex epidemiological dynamic of EEEV within Florida, implicating the Panhandle region as a possible source of the virus with sustained year-round transmission. These findings will help in implementing targeted control measures that can have the most impact in reducing or eliminating EEEV and other mosquito-borne viral infections within Florida and in the rest of the United States.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0783","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T07:01:53Z","timestamp":1552374113000},"page":"1266-1274","source":"Crossref","is-referenced-by-count":21,"title":["Complex Epidemiological Dynamics of Eastern Equine Encephalitis Virus in Florida"],"prefix":"10.4269","volume":"100","author":[{"given":"Lea A.","family":"Heberlein-Larson","sequence":"first","affiliation":[{"name":"Florida Department of Health, Bureau of Public Health Laboratories, Tampa, Florida;"},{"name":"Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian M.","family":"Stark","sequence":"additional","affiliation":[{"name":"Florida Department of Health, Bureau of Public Health Laboratories, Tampa, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Cannons","sequence":"additional","affiliation":[{"name":"Florida Department of Health, Bureau of Public Health Laboratories, Tampa, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan H.","family":"Shilts","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Unnasch","sequence":"additional","affiliation":[{"name":"Global Health Infectious Disease Research Program, Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman R.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Eastern Equine Encephalitis Epidemiology and Geographic Distribution","author":"Centers for Disease Control and Prevention","year":"2017"},{"key":"b2","series-title":"Clin Microbiol Rev","first-page":"89","article-title":"Medically important arboviruses of the United States and Canada","volume":"7","author":"Calisher","year":"1994"},{"key":"b3","series-title":"The Arboviruses: Epidemiology and Ecology","first-page":"1","article-title":"Eastern equine encephalomyelitis","author":"Morris","year":"1988"},{"key":"b4","series-title":"Adv Virus Res","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0065-3527(08)60838-6","article-title":"Eastern equine encephalomyelitis virus: epidemiology and evolution of mosquito transmission","volume":"37","author":"Scott","year":"1989"},{"key":"b5","series-title":"Morb Mortal Wkly Rep","first-page":"697","article-title":"Eastern equine encephalitis\u2014New Hampshire and Massachusetts, August\u2013September 2005","volume":"55","author":"Centers for Disease Control and Prevention (CDC)","year":"2006"},{"key":"b6","series-title":"Arbovirus Surveillance Summary, 2012","author":"Massachusetts Department of Public Health","year":"2012"},{"key":"b7","series-title":"Am J Trop Med Hyg","first-page":"974","article-title":"Epidemiology of neuroinvasive arboviral disease in the United States, 1999\u20132007","volume":"79","author":"Reimann","year":"2008"},{"key":"b8","series-title":"J Med Entomol","first-page":"501","article-title":"Epizootiology of eastern equine encephalitis virus in upstate New York, USA. 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