{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T21:10:30Z","timestamp":1722460230699},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,3]]},"abstract":"<jats:p>Yaws is a neglected tropical disease targeted for eradication by 2020. Kiribati, a Pacific Island nation, was previously endemic for yaws but lacks recent data from which its current endemicity status could be determined. This study tested antibody responses to <jats:italic>Treponema pallidum<\/jats:italic> to determine if transmission of yaws is taking place among children in Kiribati. Using a commercially available <jats:italic>T. pallidum<\/jats:italic> particle agglutination kit (Serodia<jats:sup>\u00ae<\/jats:sup>, Fujirebio Inc., Tokyo, Japan), we tested dried blood spots, collected during population-based trachoma prevalence surveys on Tarawa Atoll and Kiritimati Island, for long-lived treponemal antibodies. Dried blood spots from 1,420 children aged 1\u20139 years were tested. Only two were positive, suggesting <jats:italic>T. pallidum<\/jats:italic> is not being widely transmitted among children in the settings sampled. These data require support from additional surveys to demonstrate the absence of clinical signs of disease and molecular evidence of infection, to confirm that yaws is no longer endemic in Kiribati.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0799","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T07:00:51Z","timestamp":1549350051000},"page":"940-942","source":"Crossref","is-referenced-by-count":2,"title":["Absence of Serological Evidence of Exposure to Treponema pallidum among Children Suggests Yaws Is No Longer Endemic in Kiribati"],"prefix":"10.4269","volume":"100","author":[{"given":"Becca L.","family":"Handley","sequence":"first","affiliation":[{"name":"Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Butcher","sequence":"additional","affiliation":[{"name":"Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raebwebwe","family":"Taoaba","sequence":"additional","affiliation":[{"name":"Eye Department, Ministry of Health and Medical Services, South Tarawa, Kiribati;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrissy h","family":"Roberts","sequence":"additional","affiliation":[{"name":"Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anasaini","family":"Cama","sequence":"additional","affiliation":[{"name":"The Fred Hollows Foundation, Sydney, Australia;"},{"name":"The International Agency for the Prevention of Blindness, Melbourne, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"M\u00fceller","sequence":"additional","affiliation":[{"name":"Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland;"},{"name":"Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony W.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom;"},{"name":"Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabebe","family":"Tekeraoi","sequence":"additional","affiliation":[{"name":"Eye Department, Ministry of Health and Medical Services, South Tarawa, Kiribati;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Marks","sequence":"additional","affiliation":[{"name":"Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Trans R Soc Trop Med Hyg","first-page":"601","article-title":"Endemic treponemal diseases","volume":"108","author":"Marks","year":"2014"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e3016","article-title":"Eradication of yaws: historical efforts and achieving WHO\u2019s 2020 target","volume":"8","author":"Asiedu","year":"2014"},{"key":"b3","series-title":"Lancet","first-page":"342","article-title":"Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial","volume":"379","author":"Mitj\u00e0","year":"2012"},{"key":"b4","series-title":"Lancet","first-page":"1599","article-title":"Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study","volume":"391","author":"Mitj\u00e0","year":"2018"},{"key":"b5","series-title":"Wkly Epidemiol Rec","first-page":"189","article-title":"Eradication of yaws\u2014the Morges strategy","volume":"87","author":"World Health Organization","year":"2012"},{"author":"WHO Global Health Observatory, 2018. Neglected Tropical Diseases, WHO","key":"b6"},{"year":"2013","series-title":"Trachoma Mapping in the Pacific: Fiji, Solomon Islands and Kiribati","author":"International Agency for the Prevention of Blindness, 2013","key":"b7"},{"key":"b8","series-title":"PLoS Negl Trop Dis","first-page":"e0005863","article-title":"Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati","volume":"11","author":"Cama","year":"2017"},{"key":"b9","series-title":"BMC Infect Dis","first-page":"102","article-title":"The development and validation of dried blood spots for external quality assurance of syphilis serology","volume":"13","author":"Smit","year":"2013"},{"key":"b10","series-title":"PLoS Negl Trop Dis","first-page":"e0004927","article-title":"Prevalence of active and latent yaws in the Solomon Islands 18 months after azithromycin mass drug administration for trachoma","volume":"10","author":"Marks","year":"2016"},{"key":"b11","series-title":"Trends Parasitol","first-page":"843","article-title":"Opportunities for integrated control of neglected tropical diseases that affect the skin","volume":"32","author":"Engelman","year":"2016"},{"key":"b12","series-title":"Natl Stat Off Minist Financ","first-page":"1","article-title":"Kiribati 2010 census of population and housing","volume":"1","author":"Kiribati National Statistics Office","year":"2012"},{"key":"b13","series-title":"PLoS Negl Trop Dis","first-page":"e1746","article-title":"A diagnostics platform for the integrated mapping, monitoring, and surveillance of neglected tropical diseases: rationale and target product profiles","volume":"6","author":"Solomon","year":"2012"},{"key":"b14","series-title":"PLoS Negl Trop Dis","first-page":"e0005267","article-title":"Integrated mapping of yaws and trachoma in the five northern-most provinces Vanuatu","volume":"11","author":"Taleo","year":"2017"},{"key":"b15","series-title":"Trans R Soc Trop Med Hyg","first-page":"582","article-title":"Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji","volume":"110","author":"Cocks","year":"2016"},{"key":"b16","series-title":"Am J Trop Med Hyg","first-page":"129","article-title":"Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey","volume":"92","author":"Marks","year":"2015"},{"key":"b17","series-title":"PLoS Negl Trop Dis","first-page":"e197","article-title":"Integrating an NTD with one of \u201cthe big three\u201d: combined malaria and trachoma survey in Amhara Region of Ethiopia","volume":"2","author":"Emerson","year":"2008"},{"key":"b18","series-title":"Am J Trop Med Hyg","first-page":"858","article-title":"Quality assurance and quality control in the global trachoma mapping project","volume":"99","author":"Solomon","year":"2018"},{"key":"b19","series-title":"PLoS Negl Trop Dis","first-page":"e0004071","article-title":"Trachoma and yaws: common ground?","volume":"9","author":"Solomon","year":"2015"},{"key":"b20","series-title":"Lancet Infect Dis","first-page":"1220","article-title":"Challenges and key research questions for yaws eradication","volume":"15","author":"Marks","year":"2015"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/4\/article-p940.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/4\/article-p940.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/100\/4\/article-p940.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T20:56:09Z","timestamp":1722459369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/100\/4\/article-p940.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":20,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0799","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2019,4,3]]}}}