{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:09:44Z","timestamp":1759939784806},"reference-count":12,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,6]]},"abstract":"<jats:p>Praziquantel is widely used for treating parasitic infections globally, especially in countries with endemic schistosomiasis. However, severe hypersensitivity to praziquantel has rarely been reported. We report the case of a 30-year-old Japanese man who developed acute generalized exanthematous pustulosis (AGEP), which is a rare and severe cutaneous reaction usually triggered by drugs, after taking praziquantel. During medical examination, eggs of <jats:italic>Diphyllobothrium nihonkaiense<\/jats:italic> were found in his stool. He took praziquantel 600 mg for 1 day and developed skin rashes and fever the next day. Pruritic generalized maculopapular erythematous eruptions were observed over the entire body. He had elevated white blood cell count, liver enzymes, and C-reactive protein level. We prescribed acetaminophen, fexofenadine hydrochloride, loxoprofen sodium, and topical ointments including difluprednate and hydrocortisone. Over the next 3 days, he developed pinhead-sized, non-follicular pustules on his diffusely erythematous skin. Histological findings of the pustular lesion showed spongiform subcorneal pustules with perivascular inflammatory cells. Approximately 8 days after taking praziquantel, the pustules resolved with desquamation. He became afebrile on day 9 and his laboratory parameters returned to normal levels on day 16. He was diagnosed with AGEP caused by praziquantel. Physicians need to be aware that praziquantel could cause AGEP, although it is generally considered a safe drug.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0832","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T08:36:06Z","timestamp":1548146166000},"page":"700-702","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel"],"prefix":"10.4269","volume":"100","author":[{"given":"Tatsuya","family":"Shindo","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Kobe City Medical Center General Hospital, Kobe, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kobe City Medical Center General Hospital, Kobe, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kobe City Medical Center General Hospital, Kobe, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Kobe City Medical Center General Hospital, Kobe, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Korean J Parasitol","first-page":"273","article-title":"Hypersensitive reaction to praziquantel in a clonorchiasis patient","volume":"49","author":"Lee","year":"2011"},{"key":"b2","series-title":"Am J Trop Med Hyg","first-page":"603","article-title":"A case of anaphylactic reaction to praziquantel treatment","volume":"76","author":"Shen","year":"2007"},{"key":"b3","series-title":"Korean J Parasitol","first-page":"73","article-title":"A paragonimiasis patient with allergic reaction to praziquantel and resistance to triclabendazole: successful treatment after desensitization to praziquantel","volume":"49","author":"Kyung","year":"2011"},{"key":"b4","series-title":"J Allergy Clin Immunol","first-page":"867","article-title":"A clinical approach to a patient with praziquantel hypersensitivity","volume":"90","author":"Huang","year":"1992"},{"key":"b5","series-title":"J Parasitol Parasit Dis","first-page":"192","article-title":"Allergic manifestation after pyquiton treatment of schistosomiasis [in Chinese]","volume":"2","author":"Liu","year":"1984"},{"key":"b6","series-title":"Arch Dermatol","first-page":"1333","article-title":"Acute generalized exanthematous pustulosis. 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