{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:53:53Z","timestamp":1788407633100,"version":"build-2803163510"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Maternal rectovaginal colonization is the major risk factor for early-onset neonatal sepsis due to Group B <jats:italic>Streptococcus<\/jats:italic> (GBS), a major cause of early life morbidity and mortality. Transmission generally occurs perinatally from colonized mothers to infants. Vaccines targeting a subset of GBS serotypes are under development, but GBS epidemiology remains poorly understood in many African nations. We performed a cross-sectional study of GBS colonization among pregnant women at two sites in Botswana, a country with minimal prior GBS carriage data. We found a rectovaginal colonization rate of 19%, comparable with studies in other regions; however, we also noted a striking predominance of serotype V (&gt; 45% of strains). Although further studies are required to delineate the burden of invasive GBS disease in Botswana and the generalizability of type V epidemiology, these data provide a useful baseline for understanding the potential local impact of GBS prevention strategies, including vaccines.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0847","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T09:25:47Z","timestamp":1553678747000},"page":"1115-1117","source":"Crossref","is-referenced-by-count":9,"title":["High Rate of Serotype V Streptococcus agalactiae Carriage in Pregnant Women in Botswana"],"prefix":"10.4269","volume":"100","author":[{"given":"Brady","family":"A\u2019Hearn-Thomas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameneh","family":"Khatami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University School of Medicine, New York, New York;"},{"name":"Department of Microbiology, New York University School of Medicine, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M.","family":"Randis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University School of Medicine, New York, New York;"},{"name":"Department of Microbiology, New York University School of Medicine, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Vurayai","sequence":"additional","affiliation":[{"name":"National Health Laboratory, Gaborone, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Mokomane","sequence":"additional","affiliation":[{"name":"National Health Laboratory, Gaborone, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"Arscott-Mills","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia Department of Pediatrics, Botswana-UPenn Partnership and Global Health Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;"},{"name":"Department of Paediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis M.","family":"Banda","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiny","family":"Mazhani","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thabo","family":"Lepere","sequence":"additional","affiliation":[{"name":"Bamalete Lutheran Hospital, Ramotswa, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponatshego","family":"Gaolebale","sequence":"additional","affiliation":[{"name":"Princess Marina Hospital, Gaborone, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seeletso","family":"Nchingane","sequence":"additional","affiliation":[{"name":"Princess Marina Hospital, Gaborone, Botswana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Chamby","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University School of Medicine, New York, New York;"},{"name":"Department of Microbiology, New York University School of Medicine, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Gegick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University School of Medicine, New York, New York;"},{"name":"Department of Microbiology, New York University School of Medicine, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Suzman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University School of Medicine, New York, New York;"},{"name":"Department of Microbiology, New York University School of Medicine, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Steenhoff","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia Department of Pediatrics, Botswana-UPenn Partnership and Global Health Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;"},{"name":"Department of Paediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana;"},{"name":"Division of Pediatric Infectious Diseases, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Ratner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University School of Medicine, New York, New York;"},{"name":"Department of Microbiology, New York University School of Medicine, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Nat Commun","first-page":"4544","article-title":"Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline","volume":"5","author":"Da Cunha","year":"2014"},{"key":"b2","series-title":"MMWR Recomm 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