{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:33:18Z","timestamp":1790530398354,"version":"4.1.0"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,6]]},"abstract":"<jats:p>Scrub typhus (ST, <jats:italic>Orientia tsutsugamushi<\/jats:italic>), murine typhus (MT, <jats:italic>Rickettsia typhi<\/jats:italic>), and dengue virus (DENV) are important causes of childhood morbidity in Cambodia. This prospective, cross-sectional seroprevalence study determined the proportion of Cambodian children infected by these pathogens and the ages at which initial infection is likely to occur. A total of 993 patient serum samples were tested for MT- and ST-specific IgG, and 837 samples tested for DENV-specific IgG. Overall, ST, MT, and DENV seroprevalence was high, estimated at 4.2%, 5.3%, and 50.7%, respectively. Scrub typhus and MT seropositivity peaked in children aged 8\u201311 and 12\u201315 years, respectively, suggesting initial infection occurs in these ages. Dengue virus seroprevalence steadily increased with age, indicating constant DENV exposure. The results of this study suggest that in Cambodian children presenting with undifferentiated febrile illness, dengue should be considered high in the list of differential diagnoses, and empirical anti-rickettsial antimicrobial therapy may be more indicated in 8- to 15-year-olds.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0865","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T08:43:07Z","timestamp":1548146587000},"page":"635-638","source":"Crossref","is-referenced-by-count":14,"title":["Seroprevalence of Dengue Virus and Rickettsial Infections in Cambodian Children"],"prefix":"10.4269","volume":"100","author":[{"given":"Andrew","family":"Fox-Lewis","sequence":"first","affiliation":[{"name":"Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia;"},{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia;"},{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poda","family":"Sar","sequence":"additional","affiliation":[{"name":"Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia;"},{"name":"Angkor Hospital for Children, Siem Reap, Cambodia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Sao","sequence":"additional","affiliation":[{"name":"Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia;"},{"name":"Angkor Hospital for Children, Siem Reap, Cambodia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoun","family":"Pheaktra","sequence":"additional","affiliation":[{"name":"Angkor Hospital for Children, Siem Reap, Cambodia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P. J.","family":"Day","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom;"},{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart D.","family":"Blacksell","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom;"},{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Turner","sequence":"additional","affiliation":[{"name":"Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia;"},{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e0003575","article-title":"Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update","volume":"9","author":"Hotez","year":"2015"},{"key":"b2","series-title":"PLoS One","first-page":"e44269","article-title":"Mapping the aetiology of non-malarial febrile illness in Southeast Asia through a systematic review\u2014terra incognita impairing treatment policies","volume":"7","author":"Acestor","year":"2012"},{"key":"b3","series-title":"PLoS One","first-page":"e60634","article-title":"A prospective study of the causes of febrile illness requiring hospitalization in children in Cambodia","volume":"8","author":"Chheng","year":"2013"},{"key":"b4","series-title":"Curr Opin Infect 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