{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:31:44Z","timestamp":1753356704375},"reference-count":51,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,5]]},"abstract":"Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether Schistosoma mansoni<\/jats:italic> infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (\u223c600 m) or high (\u223c1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset (n<\/jats:italic> = 96) of these had been previously assessed and treated for schistosomiasis \u00b1 malaria 2 weeks prior. Fitness scores on the 20mSRT were translated into VO2max using a standardized equation. Unadjusted and multivariable-adjusted analyses were performed using VO2max as the primary outcome. Analysis of fitness scores from 304 children, inclusive of the subset follow-up cohort, revealed a median VO2max of 45.4 mL kg\u22121<\/jats:sup> min\u22121<\/jats:sup> (interquartile range: 42.9\u201348.0 mL kg\u22121<\/jats:sup> min\u22121<\/jats:sup>). Children residing at high altitudes demonstrated increased aerobic capacities (46.3 versus 44.8 mL kg\u22121<\/jats:sup> min\u22121<\/jats:sup>, P<\/jats:italic> = 0.031). The prevalence of stunting, wasting, S. mansoni<\/jats:italic> egg patent infection, malaria, giardiasis, anemia, and fecal occult blood were 36.7%, 16.1%, 44.3%, 65.2%, 21.4%, 50.6%, and 41.2%, respectively. Median VO2max was elevated in those previously treated, compared with those newly recruited (46.3 versus 44 mL kg\u22121<\/jats:sup> min\u22121<\/jats:sup>, P<\/jats:italic> < 0.001). Multivariable-adjusted analysis revealed a strong negative association between S. mansoni<\/jats:italic> egg patent infection and VO2max at low altitude (beta coefficient: \u22123.96, 95% CI: \u22126.56 to \u2212137, P<\/jats:italic> = 0.004). This is the first study to document a negative association between S. mansoni<\/jats:italic> infection and aerobic capacity at low altitudes using the 20mSRT.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0922","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T07:00:38Z","timestamp":1555398038000},"page":"1498-1506","source":"Crossref","is-referenced-by-count":9,"title":["Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children"],"prefix":"10.4269","volume":"100","author":[{"given":"Courtney","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajri","family":"Al Shehri","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Adriko","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Arinaitwe","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Atuhaire","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edridah","family":"Muheki Tukahebwa","sequence":"additional","affiliation":[{"name":"Vector Control Division, Ministry of Health, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. James","family":"LaCourse","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Stanton","sequence":"additional","affiliation":[{"name":"Lancaster Medical School, Lancaster University, Lancaster, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Russell","family":"Stothard","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaya L.","family":"Bustinduy","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"1561","article-title":"Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis","volume":"365","author":"King","year":"2005"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e1213","article-title":"Measuring fitness of Kenyan children with polyparasitic infections using the 20-meter shuttle run test as a morbidity metric","volume":"5","author":"Bustinduy","year":"2011"},{"key":"b3","series-title":"Am J Trop Med Hyg","first-page":"433","article-title":"Impact of polyparasitic infections on anemia and undernutrition among Kenyan children living in a Schistosoma haematobium-endemic area","volume":"88","author":"Bustinduy","year":"2013"},{"key":"b4","series-title":"J Infect Dis","first-page":"2160","article-title":"Functional significance of low-intensity polyparasite helminth infections in anemia","volume":"192","author":"Ezeamama","year":"2005"},{"key":"b5","series-title":"Am J Trop Med Hyg","first-page":"540","article-title":"Helminth infection and cognitive impairment among Filipino children","volume":"72","author":"Ezeamama","year":"2005"},{"key":"b6","series-title":"J Trop Pediatr Environ Child Health","first-page":"115","article-title":"Physiological responses to exercise in east African children. 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