{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:04:45Z","timestamp":1772165085849,"version":"3.50.1"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>Latent tuberculosis infection (LTBI) remains the main source of new active tuberculosis (TB) cases worldwide. Household close contacts (HCCs) are at high risk of acquiring LTBI and subsequent development of TB. In this study, we aim to identify risk factors associated with LTBI in HCCs of TB patients living in a low TB-incidence setting. Our results revealed that HCCs who are aged more than 50 years (OR = 4.05) and overweight (OR = 15.3) are at higher risk of acquiring LTBI. None of these LTBI household contacts progressed to active TB. These findings suggest that HCCs who are young adults and children with normal and low body mass index are less likely to acquire LTBI after exposure to TB patients, even in low TB-incidence settings.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0927","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T07:00:40Z","timestamp":1553583640000},"page":"1141-1144","source":"Crossref","is-referenced-by-count":16,"title":["Overweight, Obesity, and Older Age Favor Latent Tuberculosis Infection among Household Contacts in Low Tuberculosis-Incidence Settings within Panama"],"prefix":"10.4269","volume":"100","author":[{"given":"Idalina","family":"Cubilla-Batista","sequence":"first","affiliation":[{"name":"Tuberculosis Biomarker Research Unit, Centro de Biolog\u00eda Molecular y Celular de Enfermedades, Instituto de Investigaciones Cient\u00edficas y Servicios de Alta Tecnolog\u00eda (INDICASAT-AIP), Ciudad del Saber, Panama;"},{"name":"Laboratorio Cl\u00ednico, Hospital Rafael Estevez, Caja de Seguro Social, Aguadulce, Panama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Tuberculosis Biomarker Research Unit, Centro de Biolog\u00eda Molecular y Celular de Enfermedades, Instituto de Investigaciones Cient\u00edficas y Servicios de Alta Tecnolog\u00eda (INDICASAT-AIP), Ciudad del Saber, Panama;"},{"name":"Laboratorio Cl\u00ednico, Hospital Rafael Estevez, Caja de Seguro Social, Aguadulce, Panama;"},{"name":"Maestr\u00eda de Ciencias Biom\u00e9dicas, Facultad de Medicina de la Universidad de Panam\u00e1, Panama City, Panama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilcia","family":"Sambrano","sequence":"additional","affiliation":[{"name":"Tuberculosis Biomarker Research Unit, Centro de Biolog\u00eda Molecular y Celular de Enfermedades, Instituto de Investigaciones Cient\u00edficas y Servicios de Alta Tecnolog\u00eda (INDICASAT-AIP), Ciudad del Saber, Panama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Castillo","sequence":"additional","affiliation":[{"name":"Facultad de Inform\u00e1tica, Electr\u00f3nica y Comunicaci\u00f3n, Extensi\u00f3n Universitaria de Aguadulce, Universidad de Panam\u00e1, Cocl\u00e9, Panama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markela O.","family":"de Quinzada","sequence":"additional","affiliation":[{"name":"Maestr\u00eda de Ciencias Biom\u00e9dicas, Facultad de Medicina de la Universidad de Panam\u00e1, Panama City, Panama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Gasteluiturri","sequence":"additional","affiliation":[{"name":"Laboratorio Cl\u00ednico, Hospital Rafael Estevez, Caja de Seguro Social, Aguadulce, Panama;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amador","family":"Goodridge","sequence":"additional","affiliation":[{"name":"Tuberculosis Biomarker Research Unit, Centro de Biolog\u00eda Molecular y Celular de Enfermedades, Instituto de Investigaciones Cient\u00edficas y Servicios de Alta Tecnolog\u00eda (INDICASAT-AIP), Ciudad del Saber, Panama;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Global Tuberculosis Report 2018","first-page":"243","author":"WHO","year":"2018"},{"key":"b2","series-title":"Lancet Infect Dis","first-page":"261","article-title":"The global burden of tuberculosis: results from the Global Burden of Disease Study 2015","volume":"18","author":"GBD Tuberculosis Collaborators","year":"2018"},{"key":"b3","series-title":"Tuberculosis (Edinb)","first-page":"373","article-title":"Latent tuberculosis infection\u2013revisiting and revising concepts","volume":"95","author":"Salgame","year":"2015"},{"key":"b4","series-title":"MMWR Recomm Rep","first-page":"1","article-title":"Updated guidelines for using interferon gamma release assays to detect Mycobacterium 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