{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:47:55Z","timestamp":1790858875003,"version":"4.1.0"},"reference-count":89,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,4]]},"abstract":"<jats:p>The neglected tropical diseases Zika, Ebola, and Lassa fever (LF) have all been noted to cause some degree of hearing loss (HL). Hearing loss is a chronic disability that can lead to a variety of detrimental effects, including speech and language delays in children, decreased economic productivity in adults, and accelerated cognitive decline in older adults. The objective of this review is to summarize what is known regarding HL secondary to these viruses. Literature for this review was gathered using the PubMed database. Articles were excluded if there were no data of the respective viruses, postinfectious complications, or conditions related to survivorship. A total of 50 articles were included in this review. Fourteen articles discussing Zika virus and subsequent complications were included. Across these studies, 56 (21.2%) of 264 Zika-infected individuals were found to have HL. Twenty-one articles discussing Ebola virus and subsequent complications were included, with 190 (5.7%) of 3,350 Ebola survivors found to have HL. Fifteen additional articles discussing LF and subsequent complications were included. Of 926 individuals with LF, 79 (8.5%) were found to have HL. These results demonstrate a relationship between HL and infection. The true prevalence is likely underestimated, however, because of lack of standardization of reporting and measurement. Future studies of viral sequelae would benefit from including audiometric evaluation. This information is critical to understanding pathophysiology, preventing future cases of this disability, and improving quality of life after survival of infection.<\/jats:p>","DOI":"10.4269\/ajtmh.18-0934","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T07:00:50Z","timestamp":1563865250000},"page":"484-490","source":"Crossref","is-referenced-by-count":38,"title":["A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever"],"prefix":"10.4269","volume":"101","author":[{"given":"Samuel C.","family":"Ficenec","sequence":"first","affiliation":[{"name":"Tulane University School of Medicine, New Orleans, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Schieffelin","sequence":"additional","affiliation":[{"name":"Tulane University School of Medicine, New Orleans, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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elimination","volume":"Vol. 582","author":"Hotez","year":"2006"},{"key":"b4","series-title":"PLoS Negl Trop Dis","first-page":"e230","article-title":"Stigma: the stealth weapon of the NTD","volume":"2","author":"Hotez","year":"2008"},{"key":"b5","series-title":"PLoS Negl Trop Dis","first-page":"e237","article-title":"Stigma and the social burden of neglected tropical diseases","volume":"2","author":"Weiss","year":"2008"},{"key":"b6","author":"World Health Organization","year":"2008"},{"key":"b7","series-title":"Lancet","first-page":"1260","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"GBD 2016 DALYs, HALE Collaborator","year":"2017"},{"key":"b8","series-title":"Ann Trop Med Parasitol","first-page":"565","article-title":"Deafness\u2014the neglected and hidden disability","volume":"103","author":"Mackenzie","year":"2009"},{"key":"b9","series-title":"Lancet","first-page":"1545","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Disease and Injury Incidence and Prevalence Collaborators","year":"2016"},{"key":"b10","series-title":"Int J Technol Assess Health Care","first-page":"1120","article-title":"The societal costs of severe to profound hearing loss in the United States","volume":"16","author":"Mohr","year":"2000"},{"key":"b11","series-title":"J Speech Hear Disord","first-page":"53","article-title":"Effects of mild and moderate hearing impairments on language, educational, and psychosocial behavior of children","volume":"51","author":"Davis","year":"1986"},{"key":"b12","series-title":"Ear Hear","first-page":"339","article-title":"Children with minimal sensorineural hearing loss: prevalence, educational performance, and functional status","volume":"19","author":"Bess","year":"1998"},{"key":"b13","series-title":"J Gerontol A Biol Sci Med Sci","first-page":"1131","article-title":"Hearing loss and cognition among older adults in the United States","volume":"66","author":"Lin","year":"2011"},{"key":"b14","series-title":"JAMA Intern Med","first-page":"293","article-title":"Hearing loss and cognitive decline in older adults","volume":"173","author":"Lin","year":"2013"},{"key":"b15","series-title":"Ann Otol Rhinol Laryngol","first-page":"963","article-title":"Sudden perceptive deafness and viral infection","volume":"66","author":"Van Dishoeck","year":"1957"},{"key":"b16","series-title":"Laryngoscope","first-page":"647","article-title":"Sudden hearing loss: eight years\u2019 experience and suggested prognostic table","volume":"94","author":"Byl","year":"1984"},{"key":"b17","series-title":"Otolaryngol Clin North Am","first-page":"63","article-title":"Viral causes of sudden inner ear deafness","volume":"11","author":"Jaffe","year":"1978"},{"key":"b18","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"917","article-title":"Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection\u2014Brazil, November 2015\u2013May 2016","volume":"65","author":"Leal","year":"2016"},{"key":"b19","series-title":"J Infect Dis","first-page":"S28","article-title":"Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epid\u00e9mies \u00e0 Kikwit","volume":"179","author":"Rowe","year":"1999"},{"key":"b20","series-title":"JAMA","first-page":"2093","article-title":"Acute sensorineural deafness in Lassa fever","volume":"264","author":"Cummins","year":"1990"},{"key":"b21","series-title":"Trends Hear","first-page":"1","article-title":"Viral causes of hearing loss: a review for hearing health professionals","volume":"18","author":"Cohen","year":"2014"},{"key":"b22","series-title":"Audiol Commun Res","article-title":"Achados otol\u00f3gicos em pacientes p\u00f3s-infec\u00e7\u00e3o pelo Zika v\u00edrus: estudos de caso","volume":"22","author":"Martins","year":"2017"},{"key":"b23","series-title":"Emerg Infect Dis","first-page":"911","article-title":"Acute Zika virus infection after travel to Malaysian Borneo, September 2014","volume":"21","author":"Tappe","year":"2015"},{"key":"b24","series-title":"Clin Infect Dis","first-page":"675","article-title":"Transient hearing loss in adults associated with Zika virus infection","volume":"64","author":"Vinhaes","year":"2017"},{"key":"b25","series-title":"Braz J Otorhinolaryngol","first-page":"30126","article-title":"Sensorineural hearing loss in a case of congenital Zika virus","volume":"16","author":"Leal","year":"2016"},{"key":"b26","series-title":"PLoS One","first-page":"e0201495","article-title":"Skills attained by infants with congenital Zika syndrome: pilot data from Brazil","volume":"13","author":"Wheeler","year":"2018"},{"key":"b27","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"1347","article-title":"Health and development at age 19\u201324 Months of 19 children who were born with microcephaly and laboratory evidence of congenital Zika virus infection during the 2015 Zika virus outbreak\u2014Brazil, 2017","volume":"66","author":"Satterfield-Nash","year":"2017"},{"key":"b28","series-title":"Am J Trop Med Hyg","first-page":"151","article-title":"Case report: microcephaly in twins due to the Zika virus","volume":"97","author":"Santos","year":"2017"},{"key":"b29","series-title":"Emerg Infect Dis","first-page":"1090","article-title":"Microcephaly in infants, Pernambuco State, Brazil, 2015","volume":"22","author":"Microcephaly Epidemic Research Group","year":"2016"},{"key":"b30","series-title":"J Clin Virol","first-page":"57","article-title":"Evolution of symptoms and quality of life during Zika virus infection: a 1-year prospective cohort study","volume":"109","author":"de Laval","year":"2018"},{"key":"b31","series-title":"Ophthalmic Surg Lasers Imaging Retina","first-page":"e93","article-title":"First locally acquired congenital Zika syndrome case in the United States: neonatal clinical manifestations","volume":"49","author":"Ventura","year":"2018"},{"key":"b32","series-title":"Int J Environ Res Public Health","first-page":"E1990","article-title":"Growth and development of children with microcephaly associated with congenital Zika virus syndrome in Brazil","volume":"15","author":"Fran\u00e7a","year":"2018"},{"key":"b33","series-title":"J Trop Pediatr","first-page":"1","article-title":"Children born to mothers with rash during Zika virus epidemic in Brazil: first 18 Months of life","volume":"19","author":"Vianna","year":"2019"},{"key":"b34","series-title":"Pediatr Infect Dis J","first-page":"1","article-title":"Outcomes of congenital Zika virus infection during an outbreak in Valle del Cauca, Colombia","volume":"38","author":"Calle-Giraldo","year":"2019"},{"key":"b35","series-title":"Pediatrics","first-page":"S154","article-title":"Development of infants with congenital Zika syndrome: what do we know and what can we expect?","volume":"141","author":"Wheeler","year":"2018"},{"key":"b36","series-title":"Lancet","first-page":"498","article-title":"Late Ebola virus relapse causing meningoencephalitis: a case report","volume":"388","author":"Jacobs","year":"2016"},{"key":"b37","series-title":"Lancet Infect Dis","first-page":"3 31","article-title":"Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study","volume":"16","author":"Mattia","year":"2016"},{"key":"b38","series-title":"Clin Infect Dis","first-page":"1035","article-title":"Study of Ebola virus disease survivors in Guinea","volume":"61","author":"Qureshi","year":"2015"},{"key":"b39","series-title":"Clin Infect Dis","first-page":"1360","article-title":"Ebola virus disease complications as experienced by survivors in Sierra Leone","volume":"62","author":"Tiffany"},{"key":"b40","series-title":"Lancet Infect Dis","first-page":"545","article-title":"Multidisciplinary assessment of post-Ebola sequelae in Guinea (Postebogui): an observational cohort study","volume":"17","author":"Etard","year":"2017"},{"key":"b41","series-title":"Ophthalmology","first-page":"170","article-title":"Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in monrovia, Liberia","volume":"124","author":"Shantha","year":"2017"},{"key":"b42","series-title":"J Infect Dis","first-page":"S1","article-title":"Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients","volume":"179","author":"Bwaka","year":"1999"},{"key":"b43","series-title":"Lancet Infect Dis","first-page":"905","article-title":"Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study","volume":"15","author":"Clark","year":"2015"},{"key":"b44","series-title":"Clin Infect Dis","first-page":"131","article-title":"Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study","volume":"66","author":"Jagadesh","year":"2018"},{"key":"b45","series-title":"Biomed Res Int","first-page":"1","article-title":"Post-Ebola syndrome among Ebola virus disease survivors in Montserrado County, Liberia 2016","volume":"2018","author":"Wilson","year":"2018"},{"key":"b46","series-title":"Clin Infect Dis","first-page":"125","article-title":"Sequelae of Ebola virus disease, Kenema district, Sierra Leone","volume":"62","author":"Nanyonga","year":"2016"},{"key":"b47","series-title":"Clin Infect Dis","first-page":"1388","article-title":"Neurological, cognitive, and psychological findings among survivors of Ebola virus disease from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo: a cross-sectional study","volume":"68","author":"Kelly","year":"2018"},{"key":"b48","series-title":"Am J Ophthalmol","first-page":"114","article-title":"Ocular complications in survivors of the Ebola outbreak in Guinea","volume":"175","author":"Hereth-Hebert","year":"2017"},{"key":"b49","series-title":"Lancet Glob Health","first-page":"e678","article-title":"Pregnancy outcomes in Liberian women who conceived after recovery from Ebola virus disease","volume":"4","author":"Fallah","year":"2016"},{"key":"b50","series-title":"PLoS One","first-page":"e0209655","article-title":"Surviving Ebola: a historical cohort study of Ebola mortality and survival in Sierra Leone 2014\u20132015","volume":"13","author":"Wing","year":"2018"},{"key":"b51","series-title":"PLoS One","first-page":"e0206595","article-title":"Stigma and Ebola survivorship in Liberia: results from a longitudinal cohort study","volume":"13","author":"Overholt","year":"2018"},{"key":"b52","series-title":"Emerg Infect Dis","first-page":"1412","article-title":"Case series of severe neurologic sequelae of Ebola virus disease during epidemic, Sierra Leone","volume":"24","author":"Howlett","year":"2018"},{"key":"b53","series-title":"Open Forum Infect Dis","first-page":"ofy239","article-title":"Care of Ebola survivors and factors associated with clinical sequelae\u2014Monrovia, Liberia","volume":"5","author":"de St Maurice","year":"2018"},{"key":"b54","series-title":"N Engl J Med","first-page":"924","article-title":"A longitudinal study of Ebola sequelae in Liberia","volume":"380","author":"The PREVAIL III Study Group","year":"2019"},{"key":"b55","series-title":"PLoS Negl Trop Dis","first-page":"e0007185","article-title":"Ebola virus disease-related stigma among survivors declined in Liberia over an 18-month, post-outbreak period: an observational cohort study","volume":"13","author":"Kelly","year":"2019"},{"key":"b56","series-title":"J Med Case Rep","first-page":"36","article-title":"Sensorineural hearing loss in Lassa fever: two case reports","volume":"3","author":"Okokhere","year":"2009"},{"key":"b57","series-title":"Lancet","first-page":"649","article-title":"Isolated case of Lassa fever in Zaria, Northern Nigeria","volume":"316","author":"Grundy","year":"1980"},{"key":"b58","series-title":"Open Forum Infect Dis","first-page":"ofy131","article-title":"A case of Lassa fever diagnosed at a community hospital\u2014Minnesota 2014","volume":"5","author":"Choi","year":"2018"},{"key":"b59","series-title":"Open Forum Infect Dis","first-page":"ofw198","article-title":"Imported case of Lassa fever in Sweden with encephalopathy and sensorineural hearing deficit","volume":"3","author":"Grahn","year":"2016"},{"key":"b60","series-title":"J Infect Dis","first-page":"445","article-title":"A case-control study of the clinical diagnosis and course of Lassa fever","volume":"155","author":"McCormick","year":"1987"},{"key":"b61","series-title":"Emerg Infect Dis","first-page":"835","article-title":"Historical Lassa fever reports and 30-year clinical update","volume":"12","author":"Macher","year":"2006"},{"key":"b62","series-title":"Eur Arch Otorhinolaryngol","first-page":"197","article-title":"Early-onset sensorineural hearing loss in Lassa fever","volume":"268","author":"Ibekwe","year":"2011"},{"key":"b63","series-title":"Trans R Soc Trop Med Hyg","first-page":"390","article-title":"Lassa fever: a study of 23 hospital cases","volume":"66","author":"White","year":"1972"},{"key":"b64","series-title":"Am J Trop Med Hyg","first-page":"780","article-title":"Clinical presentation of Lassa fever cases during the hospital epidemic at Zorzor, Liberia, March-April 1972","volume":"22","author":"Mertens","year":"1973"},{"key":"b65","series-title":"Lancet Infect Dis","first-page":"684","article-title":"Clinical and laboratory predictors of assa fever outcome in a dedicated treatment facility in Nigeria: a retrospective, observational cohort study","volume":"18","author":"Okokhere","year":"2018"},{"key":"b66","series-title":"J Infect Dis","first-page":"345","article-title":"Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum","volume":"184","author":"G\u00fcnther","year":"2001"},{"key":"b67","series-title":"Rev Infect Dis","first-page":"S783","article-title":"Clinical features of Lassa fever in Liberia","volume":"11","author":"Frame","year":"1989"},{"key":"b68","series-title":"Am J Trop Med Hyg","first-page":"408","article-title":"Pediatric Lassa fever: a review of 33 Liberian cases","volume":"36","author":"Frame","year":"1987"},{"key":"b69","series-title":"J Infect Dis","first-page":"872","article-title":"An imported case of Lassa fever with late appearance of polyserositis","volume":"158","author":"Hirabayashi","year":"1988"},{"key":"b70","series-title":"Int J Audiol","first-page":"17","article-title":"Negative consequences of uncorrected hearing loss\u2014a review","volume":"42","author":"Arlinger","year":"2003"},{"key":"b71","series-title":"J Deaf Stud Deaf Educ","first-page":"1","article-title":"Mental health in deaf adults: symptoms of anxiety and depression among hearing and deaf individuals","volume":"12","author":"Kvam","year":"2007"},{"key":"b72","series-title":"Psychosom Med","first-page":"776","article-title":"Moderate effects of hearing loss on mental health and subjective well-being: results from the Nord-Tr\u00f8ndelag hearing loss study","volume":"6","author":"Tambs","year":"2004"},{"key":"b73","series-title":"Korean J Fam Med","first-page":"57","article-title":"Mental health of the people with hearing impairment in Korea: a population-based cross-sectional study","volume":"38","author":"Shin","year":"2017"},{"key":"b74","series-title":"JAMA Otolaryngol Head Neck Surg","first-page":"293","article-title":"Hearing impairment associated with depression in us adults, National Health and Nutrition Examination Survey 2005\u20132010","volume":"140","author":"Li","year":"2014"},{"key":"b75","series-title":"Rev. Bras. Otorrinolaringol","first-page":"283","article-title":"Estudo de caso: neuropatia auditiva","volume":"69","author":"Parra","year":"2003"},{"key":"b76","series-title":"J Acoust Soc Am","first-page":"2027","article-title":"A review of otoacoustic emissions","volume":"89","author":"Probst","year":"1991"},{"key":"b77","series-title":"Braz J Otorhinolaryngol","first-page":"239","article-title":"Hearing loss in congenital Zika virus","volume":"83","author":"Wiwanitkit","year":"2017"},{"key":"b78","series-title":"Sci Transl Med","first-page":"eaar2749","article-title":"Acute and chronic neurological consequences of early-life Zika virus infection in mice","volume":"10","author":"Nem de Oliveira Souza","year":"2018"},{"key":"b79","series-title":"Trends Mol Med","first-page":"778","article-title":"Viral hijacking of formins in neurodevelopmental pathologies","volume":"23","author":"Racicot","year":"2017"},{"key":"b80","series-title":"J Med Case Rep","first-page":"161","article-title":"Ocular abnormalities in congenital Zika syndrome: a case report, and review of the literature","volume":"12","author":"Guevara","year":"2018"},{"key":"b81","series-title":"Lancet Infect Dis","first-page":"e82","article-title":"Sequelae of Ebola virus disease: the emergency within the emergency","volume":"16","author":"Vetter","year":"2016"},{"key":"b82","series-title":"Curr Opin Virol","first-page":"90","article-title":"Human immune system mouse models of Ebola virus infection","volume":"25","author":"Spengler","year":"2017"},{"key":"b83","series-title":"PLoS Pathog","first-page":"e1006932","article-title":"Disabling of lymphocyte immune response by Ebola virus","volume":"14","author":"Younan","year":"2018"},{"key":"b84","series-title":"Ocul Immunol Inflamm","first-page":"1128","article-title":"Clinical manifestations and pathogenesis of uveitis in Ebola virus disease survivors","volume":"26","author":"Yeh","year":"2018"},{"key":"b85","series-title":"mBio","article-title":"Autoimmune associated systemic vasculitis as the cause of sudden onset bilateral sensorineural hearing loss following Lassa virus exposure in a cynomolgus macaque deafness model","volume":"9","author":"Cashman","year":"2018"},{"key":"b86","series-title":"Hum Vaccin Immunother","first-page":"2902","article-title":"A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever","volume":"13","author":"Cashman","year":"2017"},{"key":"b87","series-title":"J Microbiol","first-page":"204","article-title":"Zika virus: an emerging flavivirus","volume":"55","author":"Yun","year":"2017"},{"key":"b88","series-title":"J Virol","first-page":"2920","article-title":"Animal model of sensorineural hearing loss associated with Lassa virus infection","volume":"90","author":"Yun","year":"2015"},{"key":"b89","series-title":"JAMA","first-page":"2119","article-title":"Deafness associated with Lassa fever","volume":"264","author":"Rybak","year":"1990"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/101\/3\/article-p484.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/101\/3\/article-p484.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/101\/3\/article-p484.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T21:28:03Z","timestamp":1722461283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/101\/3\/article-p484.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":89,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-0934","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]}}}