{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:27:03Z","timestamp":1787293623192,"version":"build-2736575974"},"reference-count":10,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,2]]},"abstract":"<jats:p>We examined whether baseline mortality risk, as a function of child age and site, modified the azithromycin mortality-reduction effect in the <jats:italic>Macrolide Oraux pour R\u00e9duire les D\u00e9c\u00e8s avec un Oeil sur la R\u00e9sistance<\/jats:italic> (MORDOR) clinical trial. We used the Cox proportional hazards model with an interaction term. Three models were examined representing three sources for the baseline-risk covariate: two using sources external to MORDOR and the third leveraging data within MORDOR. All three models provided moderate evidence for the effect becoming stronger with increasing baseline mortality (<jats:italic>P<\/jats:italic> = 0.02, 0.02, and 0.07, respectively) at the rate of approximately 6\u201312% additional mortality reduction per doubling of baseline mortality. Etiological and programmatic implications of these findings are discussed.<\/jats:p>","DOI":"10.4269\/ajtmh.18-1004","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T07:01:14Z","timestamp":1549609274000},"page":"1295-1300","source":"Crossref","is-referenced-by-count":16,"title":["Effect Modification by Baseline Mortality in the MORDOR Azithromycin Trial"],"prefix":"10.4269","volume":"103","author":[{"given":"Assaf P.","family":"Oron","sequence":"first","affiliation":[{"name":"Institute for Disease Modeling, Bellevue, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Burstein","sequence":"additional","affiliation":[{"name":"Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laina D.","family":"Mercer","sequence":"additional","affiliation":[{"name":"Institute for Disease Modeling, Bellevue, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Arzika","sequence":"additional","affiliation":[{"name":"The Carter Center, Niamey, Niger;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khumbo","family":"Kalua","sequence":"additional","affiliation":[{"name":"Blantyre Institute for Community Outreach and the College of Medicine, University of Malawi, Blantyre;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakayo","family":"Mrango","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research, Dar es Salaam, Tanzania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila K.","family":"West","sequence":"additional","affiliation":[{"name":"The Dana Center, Johns Hopkins University School of Medicine, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L.","family":"Bailey","sequence":"additional","affiliation":[{"name":"The London School of Tropical Hygiene and Medicine, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis C.","family":"Porco","sequence":"additional","affiliation":[{"name":"Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;"},{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Lietman","sequence":"additional","affiliation":[{"name":"Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California;"},{"name":"Department of Ophthalmology, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"N Engl J Med","first-page":"1583","article-title":"Mass azithromycin distribution for reducing childhood mortality in 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Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/103\/3\/article-p1295.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/103\/3\/article-p1295.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/103\/3\/article-p1295.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T15:45:42Z","timestamp":1722440742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/103\/3\/article-p1295.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":10,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.18-1004","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]}}}