{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:44:12Z","timestamp":1776847452460,"version":"3.51.2"},"reference-count":25,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,7]]},"abstract":"<jats:p>Rocky Mountain spotted fever (RMSF) has been reported in Colombia since 1937. Most recent outbreaks were in 2006\u20132008, followed by the absence of recognized cases. This report describes new clinical cases of RMSF and epidemiologic investigations. Medical records were reviewed, and fieldwork, serological and molecular diagnostic testing, and bacterial isolation were performed. Fever, hypotension, abdominal discomfort, and rash accompanied by thrombocytopenia and leukopenia were the most characteristic manifestations. Two convalescent sera from the index case and sera from two dogs revealed high anti-spotted fever group <jats:italic>Rickettsia<\/jats:italic> antibody titers. <jats:italic>Rickettsia rickettsii<\/jats:italic> was isolated from case 4. Cases 2 and 3 were identified by epidemiological connection with the index case. Thus, a new cluster of cases of RMSF was identified in Antioquia, Colombia, with the occurrence of fatal cases, which indicates the active circulation of the bacteria and a potential risk for the population.<\/jats:p>","DOI":"10.4269\/ajtmh.18-1007","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T07:05:21Z","timestamp":1559631921000},"page":"336-342","source":"Crossref","is-referenced-by-count":12,"title":["A Cluster of Cases of Rocky Mountain Spotted Fever in an Area Of Colombia Not Known to be Endemic for This Disease"],"prefix":"10.4269","volume":"101","author":[{"given":"Andr\u00e9s F.","family":"Londo\u00f1o","sequence":"first","affiliation":[{"name":"Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia;"},{"name":"The University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Arango-Ferreira","sequence":"additional","affiliation":[{"name":"Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia;"},{"name":"Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Antioquia, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leidy Y.","family":"Acevedo-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Paternina","sequence":"additional","affiliation":[{"name":"Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Montes","sequence":"additional","affiliation":[{"name":"Gobernaci\u00f3n de Antioquia, Medell\u00edn, Antioquia, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Gobernaci\u00f3n de Antioquia, Medell\u00edn, Antioquia, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo B.","family":"Labruna","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Walker","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan D.","family":"Rodas","sequence":"additional","affiliation":[{"name":"Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Rickettsial Diseases","first-page":"1","article-title":"Bacteriology, taxonomy, and phylogeny of Rickettsia","author":"Fournier","year":"2007"},{"key":"b2","series-title":"Emerg Infect Dis","first-page":"1058","article-title":"Rocky Mountain spotted fever, Colombia","volume":"13","author":"Hidalgo","year":"2007"},{"key":"b3","series-title":"Am J Trop Med","first-page":"639","article-title":"A spotted fever in Tobia, Colombia","volume":"17","author":"Pati\u00f1o","year":"1937"},{"key":"b4","series-title":"Inf Quinc Epidemiol\u00f3gico Nac","first-page":"177","article-title":"Brote de Rickettsia rickettsii en Necocl\u00ed, Antioquia, febrero-marzo","volume":"11","author":"Acosta","year":"2006"},{"key":"b5","series-title":"Inf Quinc Epidemiol Nac","first-page":"145","article-title":"Estudio sindrome febril en el muncipio de Turbo, Corregimiento altos de mulatos enero 2008","volume":"13","author":"Giraldo","year":"2008"},{"key":"b6","series-title":"Mem Inst Oswaldo Cruz","first-page":"117","article-title":"Outbreak of Rocky mountain spotted fever in Cordoba, Colombia","volume":"106","author":"Hidalgo","year":"2011"},{"key":"b7","series-title":"Rev Chil Infecto","first-page":"54","article-title":"Gu\u00edas Latinoamericanas de la RIICER para el diagn\u00f3stico de las rickettsiosis transmitidas por garrapatas","volume":"31","author":"Oteo","year":"2014"},{"key":"b8","article-title":"Sitio oficial de Uramita en Antioquia, Colombia. Alcald\u00eda de Uramira. Uramita, un oriyecto para todos"},{"key":"b9","series-title":"Primeira","article-title":"Carrapatos De Importancia M\u00e9dico-Veterinaria Da Regiao Neotropical: Um Guia Ilustrado Para Identifica\u00e7\u00e3o De Esp\u00e9cies","author":"Barros-Battesti","year":"2006"},{"key":"b10","series-title":"Clin Microbiol Infect","first-page":"243","article-title":"Serologic survey for antibodies to Rickettsia among domestic and wild animal populations in Brazil","volume":"15","author":"Pena","year":"2009"},{"key":"b11","series-title":"Cad Saude Publica","first-page":"247","article-title":"Serosurvey of Rickettsia spp. in dogs and humans from an endemic area for Brazilian spotted fever in the State of S\u00e3o Paulo, Brazil","volume":"24","author":"Pinter","year":"2008"},{"key":"b12","series-title":"Ticks Tick Borne Dis","first-page":"887","article-title":"Wild and domestic animals likely involved in rickettsial endemic zones of Northwestern Colombia","volume":"8","author":"Londo\u00f1o","year":"2017"},{"key":"b13","series-title":"J Clin Microbiol","first-page":"90","article-title":"Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil, where Brazilian spotted fever is endemic","volume":"42","author":"Labruna","year":"2004"},{"key":"b14","series-title":"Int J Syst Evol Microbiol","first-page":"1449","article-title":"Phylogenetic analysis of members of the genus Rickettsia using the gene encoding the outer-membrane protein rOmpB (ompB)","volume":"50","author":"Roux","year":"2000"},{"key":"b15","series-title":"Mol Biol Evol","first-page":"2725","article-title":"MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0","volume":"30","author":"Tamura","year":"2013"},{"key":"b16","series-title":"Bioinformatics","first-page":"1572","article-title":"MrBayes 3: Bayesian phylogenetic inference under mixed models","volume":"19","author":"Ronquist","year":"2003"},{"key":"b17","series-title":"Am J Trop Med Hyg","first-page":"687","article-title":"Rocky Mountain spotted fever in Argentina","volume":"78","author":"Paddock","year":"2008"},{"key":"b18","series-title":"Epidemiol Infect","first-page":"2446","article-title":"A cluster of Rickettsia rickettsii infection at an animal shelter in an urban area of Brazil","volume":"143","author":"Rozental","year":"2015"},{"key":"b19","series-title":"J Venom Anim Toxins Incl Trop Dis","first-page":"1","article-title":"An update on the epidemiological situation of spotted fever in Brazil","volume":"22","author":"de Oliveira","year":"2016"},{"key":"b20","series-title":"Emerg Infect Dis","first-page":"2010","article-title":"Rickettsia rickettsii in Amblyomma patinoi ticks, Colombia","volume":"21","author":"Faccini-Mart\u00ednez","year":"2015"},{"key":"b21","series-title":"J Med Entomol","first-page":"418","article-title":"Rickettsia rickettsii in 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