{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:36:19Z","timestamp":1793500579462,"version":"4.5.0"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,6]]},"abstract":"<jats:p>Disseminated nontuberculous mycobacterial (NTM) infections usually occur in severely immunosuppressed patients. These infections may also occur in previously immunocompetent patients with acquired anti\u2013interferon-gamma antibodies (anti\u2013IFN-\u03b3 Abs). A previously healthy 33-year-old man presented with a 3-week history of cough and fever. Chest computed tomography showed air-space consolidation in the middle lobe of the right lung and enlargement of the supraclavicular, mediastinal, and hilar lymph nodes. Tissue samples obtained via mediastinoscopy showed granuloma formation with acid-fast bacteria; cultures from the tissue revealed <jats:italic>Mycobacterium kansasii<\/jats:italic>. Accordingly, a diagnosis of disseminated <jats:italic>M. kansasii<\/jats:italic> disease was made. The positive control tested negative in the QuantiFERON-TB Gold In-tube test, suggesting the presence of anti\u2013IFN-\u03b3 Abs. The ELISA test for anti\u2013IFN-\u03b3 Abs demonstrated an increased titer. Antimycobacterial drug treatments were initiated after diagnosis. His symptoms improved over 2 months, and he remains well on outpatient management. Disseminated <jats:italic>M. kansasii<\/jats:italic> disease is a very rare condition suggestive of immunosuppression. Testing for anti\u2013IFN-\u03b3 antibodies might be important in all cases of disseminated <jats:italic>M. kansasii<\/jats:italic> disease.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0047","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T07:01:10Z","timestamp":1569222070000},"page":"1066-1069","source":"Crossref","is-referenced-by-count":12,"title":["Case Report: Disseminated Mycobacterium kansasii Disease in a Patient with Anti\u2013Interferon-Gamma Antibody"],"prefix":"10.4269","volume":"101","author":[{"given":"Eriko","family":"Kashihara","sequence":"first","affiliation":[{"name":"Division of General Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Uchida","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;"},{"name":"Department of Drug Discovery for Lung Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Mio","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Division of General Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"N Eng J Med","first-page":"725","article-title":"Adult-onset immunodeficiency in Thailand and Taiwan","volume":"367","author":"Brown","year":"2012"},{"key":"b2","series-title":"J Clin Invest","first-page":"2480","article-title":"Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma","volume":"115","author":"Kampmann","year":"2005"},{"key":"b3","series-title":"Infection","first-page":"65","article-title":"Anti-interferon-\u03b3 autoantibody and opportunistic infections: case series and review of the literature","volume":"39","author":"Kampitak","year":"2011"},{"key":"b4","series-title":"J Infect 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