{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:09:08Z","timestamp":1787170148316,"version":"build-2736575974"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:p>Dengue guidelines for diagnosis, treatment, prevention, and control (WHO, 2011) recommend acetaminophen and isotonic fluid for patients with dengue infection but do not recommend nonsteroidal anti-inflammatory drugs (NSAIDs) and hypotonic fluid. Other research showed no evidence of efficacy of platelet infusion in prophylactic. This research aims to clarify to what extent dengue patients were managed in accordance with the guidelines in Japan. We extracted claim data of patients with either dengue fever (DF) or dengue hemorrhagic fever (DHF) from the National Database of Health Insurance Claims and Specific Health Checkups of Japan between 2011 and 2015. The total number of patients was 1,370, which consisted of 1,306 DF patients and 64 DHF patients; 185 patients were younger than (&lt;) 20 years and 1,185 patients were aged 20 years or older (\u2265). Among them, 24.5% of DF patients and 48.4% of DHF patients received hypotonic intravenous fluid, 12.9% and 18.8% NSAIDs, and 1.3% and 17.2% platelet transfusion, respectively. Comparing patients aged &lt; 20 years with patients aged \u2265 20 years, 57.8% and 54.5% received acetaminophen, 6.5% and 14.3% received NSAIDs, 40.0% and 38.3% received isotonic fluid, and 37.8% and 23.7% received hypotonic fluid, respectively. Platelet transfusion was used for 1.3% of DH and 17.2% of DHF patients. The study indicated that dengue patients in Japan might have increased risks of developing adverse events because of receiving the treatment that the guidelines do not recommend. More effort is needed to facilitate medical practitioners to follow the guidelines.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0070","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T07:01:05Z","timestamp":1572850865000},"page":"191-194","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Management of Patients with Dengue Infection in Japan: Results from National Database of Health Insurance Claims"],"prefix":"10.4269","volume":"102","author":[{"given":"Yusuke","family":"Kajimoto","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan;"},{"name":"Global Health Research Coordinating Center, Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences, Kyorin University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Investing to Overcome the Global Impact of Neglected Tropical Diseases","author":"World Health Organization","year":"2015"},{"key":"b2","series-title":"Nature","first-page":"504","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013"},{"key":"b3","series-title":"Dengue: Guidelines for Diagnosis, Treatment Prevention and Control","author":"World Health Organization","year":"2009"},{"key":"b4","series-title":"Dengue Fever, Notification from Physician and Veterinarian Based on Infectious Disease Act","author":"Ministry of Health, Labour and Welfare"},{"key":"b5","series-title":"Category IV, Annual Surveillance Data Table -2016-","author":"National Institute of Infectious Diseases","year":"2016"},{"key":"b6","series-title":"Dengue Virus Infection Information","author":"National Institute of Infectious Diseases","year":"2016"},{"key":"b7","author":"Japan International Corporation of Welfare Services","year":"2015"},{"key":"b8","series-title":"Jpn J Infect Dis","first-page":"45","article-title":"Whole genome sequencing-based molecular epidemiologic analysis of autochthonous dengue virus type 1 strains circulating in Japan in 2014","volume":"70","author":"Tajima","year":"2017"},{"key":"b9","series-title":"Tokyo Mosquito-Borne Disease Countermeasure Meeting. Report Appendix 2","author":"Tokyo Metropolitan Government","year":"2014"},{"key":"b10","series-title":"Dengue Clinical Guideline","author":"Hamada","year":"2014"},{"key":"b11","series-title":"Lancet","first-page":"1611","article-title":"Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial","volume":"389","author":"Lye","year":"2017"},{"key":"b12","series-title":"Changes in Electric Claims Data at Medical Institution Based on Numbers of Claims Data","author":"Ministry of health, Labour and Welfare"},{"key":"b13","series-title":"Guideline for Provision of Claims Data and Special Health Checkup Result etc","author":"Ministry of Health, Labour and Welfare","year":"2016"},{"key":"b14","series-title":"Emerg Infect Dis","first-page":"1663","article-title":"Recent shift in age pattern of dengue hemorrhagic fever, Brazil","volume":"14","author":"Teixeira","year":"2008"},{"key":"b15","series-title":"Indian J Pediatr","first-page":"13","article-title":"Isotonic intravenous maintenance fluid reduces hospital acquired hyponatremia in young children with central nervous system infections","volume":"82","author":"Pemde","year":"2015"},{"key":"b16","series-title":"Br J Anaesth","first-page":"836","article-title":"Should we use hypotonic or isotonic maintenance intravenous fluids in sick patients? Why a study in healthy volunteers will not provide the answer: response to: effect of isotonic versus hypotonic maintenance fluid therapy on urine output, fluid balance, and electrolyte homeostasis: a crossover study in fasting adult volunteers","volume":"119","author":"Leroy","year":"2017"},{"key":"b17","series-title":"Gastroenterology","first-page":"498","article-title":"Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population","volume":"132","author":"Garc\u00eda Rodr\u00edguez","year":"2007"},{"key":"b18","series-title":"J Gastroenterol","first-page":"992","article-title":"Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis","volume":"49","author":"Yuhara","year":"2014"},{"key":"b19","series-title":"Information Regarding to Drug Price Standard Items List and Generic Drugs","author":"Ministry of Health, Labour and Welfare","year":"2018"},{"key":"b20","series-title":"Purchasing Power Parities for GDP and Related Indicators","author":"Organisation for Economic Co-operation and Development"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/102\/1\/article-p191.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/102\/1\/article-p191.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/102\/1\/article-p191.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T15:39:45Z","timestamp":1722440385000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/102\/1\/article-p191.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":20,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.19-0070","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]}}}