{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:32:05Z","timestamp":1744187525281},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,2]]},"abstract":"<jats:p>We explored spatial variation in the prevalence of established molecular markers of antimalarial resistance across a geographically diverse, highland region of western Uganda. We identified <jats:italic>Plasmodium falciparum<\/jats:italic> CQ resistance transporter 76T mutations in all pools, but there was no evidence of spatial differences across village-based strata defined by either altitude or river valley. In contrast, we identified a significant inverse association between altitude and the prevalence of <jats:italic>Plasmodium falciparum<\/jats:italic> multidrug resistance 1 mutations with the largest proportion of Y184F mutations observed in the low-elevation, high-transmission villages. These results demonstrate the substantial heterogeneity in resistance markers observed across geographic settings, even at relatively small scales, but highlight the complex nature of these ecological relationships.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0081","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T07:00:29Z","timestamp":1566284429000},"page":"799-802","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of Molecular Markers of Antimalarial Drug Resistance across Altitudinal Transmission Zones in Highland Western Uganda"],"prefix":"10.4269","volume":"101","author":[{"given":"Ross M.","family":"Boyce","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;"},{"name":"Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Brazeau","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis","family":"Fulton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Hathaway","sequence":"additional","affiliation":[{"name":"Program in Bioinformatics and Integrative Biology, University of Massachusetts, Worcester, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Matte","sequence":"additional","affiliation":[{"name":"Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Ntaro","sequence":"additional","affiliation":[{"name":"Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Mulogo","sequence":"additional","affiliation":[{"name":"Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Juliano","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;"},{"name":"Division of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;"},{"name":"Curriculum in Genetics and Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Infect Dis","first-page":"888","article-title":"Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems","volume":"12","author":"Talisuna","year":"2012"},{"key":"b2","series-title":"N Engl J Med","first-page":"397","article-title":"The origins of antimalarial-drug resistance","volume":"371","author":"Packard","year":"2014"},{"year":"2011","series-title":"Global Plan for Artemisinin Resistance Containment (GPARC)","author":"WHO","key":"b3"},{"key":"b4","series-title":"Trans R Soc Trop Med Hyg","first-page":"S11","article-title":"The evolution of drug-resistant malaria","volume":"103","author":"Plowe","year":"2009"},{"key":"b5","series-title":"Trop Med Int Health","first-page":"1031","article-title":"Increasing antimalarial drug resistance in Uganda and revision of the national drug 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