{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:45:02Z","timestamp":1784666702566,"version":"3.55.0"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,7]]},"abstract":"<jats:p>Most deaths in tuberculous meningitis occur in the early part of the illness. We assessed the determinants of early deaths, occurring within 2 months of intensive therapy. We prospectively included consecutive newly diagnosed adults with HIV-negative tuberculous meningitis. Patients were given WHO-recommended antituberculosis treatment and were followed up for 9 months. We enrolled 152 patients. A total of 26 deaths were recorded during 2 months. The logistic regression analysis revealed that papilledema (<jats:italic>P<\/jats:italic> = 0.029, odds ratio (OR) = 4.8 [1.2\u201319.8]), increasing age (<jats:italic>P<\/jats:italic> = 0.001, OR = 1.07 [1.03\u20131.1]), stage-III disease (Glasgow coma scale score \u2264 10; <jats:italic>P<\/jats:italic> = 0.01, OR = 4.2 [1.4\u201312.3]), and hydrocephalus (<jats:italic>P<\/jats:italic> = 0.003, OR = 8.4 [2.1\u201333.6]) were independently associated with death. In addition, cerebral infarcts (<jats:italic>P<\/jats:italic> = 0.012, OR = 5.6 [1.5\u201321.3]), paraparesis (<jats:italic>P<\/jats:italic> = 0.004, OR = 8.8 [2.02\u201338.1]), and age (<jats:italic>P<\/jats:italic> = 0.005, OR = 1.05 [1.02\u20131.09]) were associated with poor functional outcome. In conclusion, disease severity predicts early deaths in tuberculous meningitis.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0098","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T11:55:39Z","timestamp":1561463739000},"page":"357-361","source":"Crossref","is-referenced-by-count":13,"title":["Early Mortality among Immunocompetent Patients of Tuberculous Meningitis: A Prospective Study"],"prefix":"10.4269","volume":"101","author":[{"given":"Ravi Shekhar","family":"Jaipuriar","sequence":"first","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep Singh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Microbiology, King George Medical University, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Uniyal","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George Medical University, Lucknow, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Wellcome Open Res","first-page":"64","article-title":"Can improved diagnostics reduce mortality from tuberculous meningitis? 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