{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:35:12Z","timestamp":1785879312799,"version":"3.56.0"},"reference-count":41,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,4]]},"abstract":"<jats:p>In low-resource settings, many children are severely ill at arrival to hospital. The risk factors for mortality among such ill children are not well-known. Understanding which of these patients are at the highest risk could assist in the allocation of limited resources to where they are most needed. A cohort study of severely ill children treated in the resuscitation room of the pediatric emergency department at Queen Elizabeth Central Hospital in Malawi was conducted over a 6-month period in 2017. Data on signs and symptoms, vital signs, blood glucose levels, and nutritional status were collected and linked with in-hospital mortality data. The factors associated with in-hospital mortality were analyzed using multivariable logistic regression. Data for 1,359 patients were analyzed and 118 (8.7%) patients died. The following factors were associated with mortality: presence of any severely deranged vital sign, unadjusted odds ratio (UOR) 2.6 (95% CI 1.7\u20134.0) and adjusted odds ratio (AOR) 3.2 (95% CI 2.0\u20135.0); severe dehydration, UOR 2.6 (1.4\u20135.1) and AOR 2.8 (1.3\u20136.0); hypoglycemia glycemia (&lt; 5 mmol\/L), UOR 3.6 (2.2\u20135.8) and AOR 2.7 (1.6\u20134.7); and severe acute malnutrition, UOR 5.8 (3.5\u20139.6) and AOR 5.7 (3.3\u201310.0). This study suggests that among severely sick children, increased attention should be given to those with hypo\/low glycemia, deranged vital signs, malnutrition, and severe dehydration to avert mortality among these high-risk patients.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0127","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T07:00:33Z","timestamp":1562655633000},"page":"670-675","source":"Crossref","is-referenced-by-count":23,"title":["Risk Factors for Mortality in Severely Ill Children Admitted to a Tertiary Referral Hospital in Malawi"],"prefix":"10.4269","volume":"101","author":[{"given":"Fatsani","family":"Ngwalangwa","sequence":"first","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikondi H. A.","family":"Phiri","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queen","family":"Dube","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Langton","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Hildenwall","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Karolinska Institutet, Global Health\u2013Health System and Policy Research Group, Stockholm, Sweden;"},{"name":"Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi;"},{"name":"Queen Elizabeth Central Hospital, Blantyre, Malawi;"},{"name":"Department of Public Health Sciences, Karolinska Institutet, Global Health\u2013Health System and Policy Research Group, Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Child Mortality Report World Health Organisation","author":"World Health Organization","year":"2017"},{"key":"b2","series-title":"Every Child Alive: The Urgent Need to End New Born Death Levels","author":"UNICEF","year":"2018"},{"key":"b3","series-title":"West Afr J Med","first-page":"249","article-title":"Mortality pattern within twenty-four hours of emergency paediatric admission in a resource-poor nation health 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