{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:21Z","timestamp":1777417101744,"version":"3.51.4"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,5]]},"abstract":"<jats:p>Pyrethroid resistance has been detected in <jats:italic>Triatoma infestans<\/jats:italic>, which in part has been attributed to increased oxidative metabolism of the insecticide by cytochrome P450s. Nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome P450 reductase (CPR) catalyzes electron transfer from NADPH to all known cytochrome P450s. In this study, the expression of the <jats:italic>CPR<\/jats:italic> gene at transcriptional level was determined in different tissues and two life stages. The expression patterns showed differences in the tissues and stages studied, suggesting differential metabolic requirements. On the other hand, to investigate the presence of rhythms in the expression of genes related with insecticide resistance, we explored the daily expression profile of the <jats:italic>CPR<\/jats:italic> gene and a <jats:italic>P450<\/jats:italic> gene (<jats:italic>CYP4EM7<\/jats:italic>) in fat body from adults of <jats:italic>T. infestans<\/jats:italic> under different dark\/light regimes. The results suggest that <jats:italic>CPR<\/jats:italic> gene expression is under endogenous clock regulation and show a rhythmic profile in the expression of the <jats:italic>CYP4EM7<\/jats:italic> gene.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0155","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T07:00:45Z","timestamp":1555398045000},"page":"1482-1485","source":"Crossref","is-referenced-by-count":5,"title":["Daily Variations in the Expression of Genes Related to Insecticide Resistance in the Chagas Disease Vector Triatoma infestans (Hemiptera: Reduviidae)"],"prefix":"10.4269","volume":"100","author":[{"given":"Gonzalo M.","family":"Varela","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), C\u00e1tedra de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda M.","family":"Stroppa","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), C\u00e1tedra de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz A.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), C\u00e1tedra de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Acta Trop","first-page":"70","article-title":"Insecticide resistance in vector Chagas disease: evolution, mechanisms and management","volume":"149","author":"Mougabure-Cueto","year":"2015"},{"key":"b2","series-title":"Annu Rev Entomol","first-page":"231","article-title":"Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics","volume":"52","author":"Li","year":"2007"},{"key":"b3","series-title":"Cytochromes P450: Structure, Mechanism and Biochemistry","first-page":"115","article-title":"Electron transfer partners of cytochrome P450","author":"Paine","year":"2004"},{"key":"b4","series-title":"Infect Genet Evol","first-page":"459","article-title":"Identification of three cytochrome P450 genes in the Chagas\u2019 disease vector Triatoma infestans: expression analysis in deltamethrin susceptible and resistant 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of NADPH-cytochrome P450 reductase results in reduced insecticide resistance in the bed bug, Cimex lectularius","volume":"7","author":"Zhu","year":"2012"}],"container-title":["The American Journal of Tropical Medicine and 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