{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:13:58Z","timestamp":1769753638818,"version":"3.49.0"},"reference-count":41,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,7]]},"abstract":"Acute diarrhea is an important public health issue. Here, we focused on the differences of enteropathogens in acute diarrhea between urban and rural areas in southeast China. Laboratory- and sentinel-based surveillance of acute diarrhea (\u2265 3 loose or liquid stools\/24 hours) was conducted at 16 hospitals. Fecal specimens were tested for bacterial (Aeromonas<\/jats:italic> sp., Campylobacter<\/jats:italic> sp., diarrheagenic Escherichia coli<\/jats:italic>, Plesiomonas shigelloides<\/jats:italic>, non-typhoidal Salmonella<\/jats:italic>, Shigella<\/jats:italic> sp., Vibrio<\/jats:italic> sp., and Yersinia<\/jats:italic> sp.) and viral (adenovirus, astrovirus, Norovirus<\/jats:italic>, Rotavirus<\/jats:italic>, and Sapovirus<\/jats:italic>) pathogens. Descriptive statistics were used. Between January 1, 2010, and December 31, 2014, 4,548 outpatients with acute diarrhea were enrolled (urban, n<\/jats:italic> = 3,220; rural, n<\/jats:italic> = 1,328). Pathogens were identified in 2,074 (45.6%) patients. Norovirus (25.7%), Vibrio parahaemolyticus<\/jats:italic> (10.2%), enteroaggregative Escherichia coli<\/jats:italic> (EAEC) (8.8%), group A Rotavirus<\/jats:italic> (7.0%), and enterotoxigenic Escherichia coli<\/jats:italic> (ETEC) (5.6%) were the most common pathogens. Enteropathogens were less common in urban than in rural areas (42.0% versus 54.4%, P<\/jats:italic> < 0.001). In urban areas, EAEC and ETEC were more common in high-income than in middle-income regions. Interventions targeting the most common enteropathogens can substantially reduce the burden of acute diarrhea in southeast China.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0171","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T07:00:26Z","timestamp":1560841226000},"page":"310-318","source":"Crossref","is-referenced-by-count":23,"title":["Prevalence of Enteropathogens in Outpatients with Acute Diarrhea from Urban and Rural Areas, Southeast China, 2010\u20132014"],"prefix":"10.4269","volume":"101","author":[{"given":"Chong","family":"Chen","sequence":"first","affiliation":[{"name":"School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China;"},{"name":"Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Xing","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;"},{"name":"MOH Key Laboratory of Systems Biology of Pathogens and Dr. Christophe M\u00e9rieux Laboratory, CAMS-Fondation M\u00e9rieux, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo-Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Zhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Fa","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China;"},{"name":"Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China;"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China;"},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Infect Dis","first-page":"909","article-title":"Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the global burden of disease study 2015","volume":"17","author":"GBD Diarrhoeal Diseases Collaborators","year":"2017"},{"key":"b2","series-title":"Lancet","first-page":"1405","article-title":"Global burden of childhood pneumonia and 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