{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:14:02Z","timestamp":1789269242417,"version":"build-2803163510"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,4]]},"abstract":"<jats:p>A 43-year-old man was admitted to the intensive care unit and diagnosed with yellow fever. He presented with refractory bleeding, extreme hyperferritinemia, and multiple organ dysfunction syndrome, requiring renal replacement therapy, mechanical ventilation, and treatment with vasoactive drugs. Because the bleeding did not respond to fresh-frozen plasma administration, the patient received therapeutic plasma exchange, which was accompanied by a marked improvement of the clinical and biochemical parameters, including a significant decline in serum ferritin levels.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0219","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T07:01:03Z","timestamp":1563260463000},"page":"705-707","source":"Crossref","is-referenced-by-count":4,"title":["Severe Yellow Fever and Extreme Hyperferritinemia Managed with Therapeutic Plasma Exchange"],"prefix":"10.4269","volume":"101","author":[{"given":"Jaques","family":"Sztajnbok","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Infectious Diseases Institute Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceila Maria","family":"Sant\u2019Ana Malaque","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Infectious Diseases Institute Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Hitomi","family":"Nihei","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Infectious Diseases Institute Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Faria","family":"Duayer","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Infectious Diseases Institute Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita Maria","family":"Leme Britto","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Infectious Diseases Institute Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda Gambini","family":"Beraldo","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Infectious Diseases Institute Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralcyon Francis","family":"AzevedoTeixeira","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Infectious Diseases Institute Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Trans R Soc Trop Med Hyg","first-page":"169","article-title":"Clinical and epidemiological characteristics of yellow fever in Brazil: analysis of reported cases 1998\u20132002","volume":"101","author":"Tuboi","year":"2007"},{"key":"b2","series-title":"J Clin Virol","first-page":"160","article-title":"Yellow fever","volume":"64","author":"Monath","year":"2015"},{"key":"b3","series-title":"Antiviral Res","first-page":"116","article-title":"Treatment of yellow fever","volume":"78","author":"Monath","year":"2008"},{"key":"b4","series-title":"Genes (Basel)","article-title":"What does the future hold for yellow fever virus? 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