{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:32:50Z","timestamp":1787031170995,"version":"build-2736575974"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,6]]},"abstract":"\n This study was performed to examine whether prenatal lipid-based nutrient supplementation is an effective means of improving birth outcomes compared with other types of supplementation including iron folic acid (IFA), United Nations multiple micronutrient preparation (UNIMAP), other multiple micronutrients (MMN), and fortified corn\u2013soy blend (CSB). A meta-analysis was performed to determine the relative risks and mean differences in birth outcomes between prenatal lipid-based nutrients versus prenatal IFA, UNIMAP, other MMN, and CSB in randomized controlled trials. Eleven databases, including PubMed (MEDLINE), were searched. Study quality was assessed using the Cochrane Collaboration\u2019s tool for assessing the risk of bias. Fifty-eight overall good-quality studies extracted from 11 eligible articles with 101,553 mother\u2013baby pairs were included. Lipid-based nutrient supplementation significantly reduced the risks of low birthweight, small for gestational age, and stunting (\n n<\/jats:italic>\n = 5, 5, and 4, respectively) and significantly increased the means of birthweight, birth length, arm circumference, and weight-for-age\n z<\/jats:italic>\n -score (\n n<\/jats:italic>\n = 5, 5, 4, and 3, respectively). Lipid-based nutrient supplementation did not significantly reduce the risk of preterm birth, stillbirth, abortion, perinatal death, or underweight (\n n<\/jats:italic>\n = 5, 5, 5, 3, or 3, respectively) or significantly increase the mean of head circumference or height-for-age\n z<\/jats:italic>\n -score (\n n<\/jats:italic>\n = 4 or 2, respectively). In conclusion, the results supported the efficacy of prenatal lipid-based nutrient supplementation compared with IFA, UNIMAP, other MMN, and CSB for reducing the risk of small birth size.\n <\/jats:p>","DOI":"10.4269\/ajtmh.19-0287","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T03:00:33Z","timestamp":1568343633000},"page":"994-999","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of Prenatal Lipid-Based Nutrient Supplementation to Improve Birth Outcomes: A Meta-analysis"],"prefix":"10.4269","volume":"101","author":[{"given":"Eita","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Medicine and Public Health, Nagoya Medical Science Research Institute, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Neonatal Perinatal Med","first-page":"233","article-title":"The influence of the built environment on adverse birth outcomes","volume":"10","author":"Woods","year":"2017"},{"key":"b2","series-title":"Am J Clin Nutr","first-page":"835","article-title":"Lipid-based nutrient supplement increases the birth size of infants of primiparous women in Ghana","volume":"101","author":"Adu-Afarwuah","year":"2015"},{"key":"b3","series-title":"Am J Clin Nutr","first-page":"387","article-title":"The impact of lipid-based nutrient supplement provision to pregnant women on newborn size in rural Malawi: a randomized controlled trial","volume":"101","author":"Ashorn","year":"2015"},{"key":"b4","series-title":"J Nutr","first-page":"1345","article-title":"Supplementation of maternal diets during pregnancy and for 6 months postpartum and infant diets thereafter with small-quantity lipid-based nutrient supplements does not promote child growth by 18 months of age in rural Malawi: a randomized controlled trial","volume":"145","author":"Ashorn","year":"2015"},{"key":"b5","series-title":"Am J Clin Nutr","first-page":"1062","article-title":"Trial of ready-to-use supplemental food and corn-soy blend in pregnant Malawian women with moderate malnutrition: a randomized controlled clinical trial","volume":"106","author":"Callaghan-Gillespie","year":"2017"},{"key":"b6","series-title":"Am J Clin Nutr","first-page":"1593","article-title":"Prenatal food supplementation fortified with multiple micronutrients increases birth length: a randomized controlled trial in rural Burkina Faso","volume":"90","author":"Huybregts","year":"2009"},{"key":"b7","series-title":"J Nutr","first-page":"576","article-title":"Prenatal lipid-based nutrient supplements increase cord leptin concentration in pregnant women from rural Burkina Faso","volume":"143","author":"Huybregts","year":"2013"},{"key":"b8","series-title":"Matern Child Nutr","first-page":"e12367","article-title":"Association of prenatal lipid-based nutritional supplementation with fetal growth in rural Gambia","volume":"13","author":"Johnson","year":"2017"},{"key":"b9","series-title":"Pediatrics","first-page":"e1001","article-title":"Prenatal nutrient supplementation and postnatal growth in a developing nation: an RCT","volume":"133","author":"Lanou","year":"2014"},{"key":"b10","series-title":"Am J Clin Nutr","first-page":"236","article-title":"Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh","volume":"103","author":"Mridha","year":"2016"},{"key":"b11","series-title":"J Nutr","first-page":"1776","article-title":"Prenatal lipid-based nutrient supplements do not affect pregnancy or childbirth complications or cesarean delivery in Bangladesh: a cluster-randomized controlled effectiveness trial","volume":"147","author":"Mridha","year":"2017"},{"key":"b12","series-title":"J Nutr","first-page":"634","article-title":"Seasonality modifies the effect of a lipid-based nutrient supplement for pregnant rural women on birth length","volume":"145","author":"Toe","year":"2015"},{"key":"b13","series-title":"Cochrane Database Syst Rev","first-page":"CD004905","article-title":"Multiple-micronutrient supplementation for women during pregnancy","volume":"4","author":"Haider","year":"2017"},{"key":"b14","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","article-title":"Introduction to sources of bias in clinical trials","author":"Higgins","year":"2011"},{"key":"b15","series-title":"BMJ","first-page":"629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997"},{"key":"b16","series-title":"Cochrane Database Syst Rev","first-page":"CD012610","article-title":"Lipid-based nutrient supplements for maternal, birth, and infant developmental outcomes","volume":"8","author":"Das","year":"2018"},{"key":"b17","series-title":"Systematic Reviews in Healthcare: Meta-Analysis in Context","author":"Egger","year":"2007"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/101\/5\/article-p994.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/101\/5\/article-p994.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/101\/5\/article-p994.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:30:37Z","timestamp":1722425437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/101\/5\/article-p994.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,6]]},"references-count":17,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.19-0287","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,6]]}}}