{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:22:16Z","timestamp":1789428136504,"version":"build-2803163510"},"reference-count":72,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:p>\n                    Accurate and cost-effective identification of areas where co-endemic infections occur would enable public health managers to identify opportunities for implementation of integrated control programs. Dried blood spots collected during cross-sectional lymphatic filariasis surveys in coastal Kenya were used for exploratory integrated detection of IgG antibodies against antigens from several parasitic infections (\n                    <jats:italic>Wuchereria bancrofti<\/jats:italic>\n                    ,\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    ,\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    spp.,\n                    <jats:italic>Ascaris lumbricoides<\/jats:italic>\n                    , and\n                    <jats:italic>Strongyloides stercoralis<\/jats:italic>\n                    ) as well as for detection of responses to immunizing agents used against vaccine-preventable diseases (VPDs) (measles, diphtheria, and tetanus) using a multiplex bead assay (MBA) platform. High heterogeneity was observed in antibody responses by pathogen and antigen across the sentinel sites. Antibody seroprevalence against filarial antigens were generally higher in Ndau Island (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001), which also had the highest prevalence of filarial antigenemia compared with other communities. Antibody responses to the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species antigens circumsporozoite protein (CSP) and merozoite surface protein-1 (MSP-1)\n                    <jats:sub>19<\/jats:sub>\n                    were higher in Kilifi and Kwale counties, with Jaribuni community showing higher overall mean seroprevalence (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001). Kimorigo community in Taita\u2013Taveta County was the only area where antibody responses against\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    Sm25 recombinant antigen were detected. Seroprevalence rates to\n                    <jats:italic>Strongyloides<\/jats:italic>\n                    antigen NIE ranged between 3% and 26%, and there was high heterogeneity in immune responses against an\n                    <jats:italic>Ascaris<\/jats:italic>\n                    antigen among the study communities. Differences were observed between communities in terms of seroprevalence to VPDs. Seroprotection to tetanus was generally lower in Kwale County than in other counties. This study has demonstrated that MBA holds promise for rapid integrated monitoring of trends of infections of public health importance in endemic areas.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.19-0365","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T02:00:42Z","timestamp":1574733642000},"page":"164-176","source":"Crossref","is-referenced-by-count":34,"title":["Integrated Cross-Sectional Multiplex Serosurveillance of IgG Antibody Responses to Parasitic Diseases and Vaccines in Coastal Kenya"],"prefix":"10.4269","volume":"102","author":[{"given":"Sammy M.","family":"Njenga","sequence":"first","affiliation":[{"name":"Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry M.","family":"Kanyi","sequence":"additional","affiliation":[{"name":"Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Francis I. Proctor Foundation, University of California, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultani H.","family":"Matendechero","sequence":"additional","affiliation":[{"name":"Department of Preventive and Promotive Services, Neglected Tropical Diseases Programme, Ministry of Health, Nairobi, Kenya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce K.","family":"Onsongo","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office, Nairobi, Kenya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly Y.","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Priest","sequence":"additional","affiliation":[{"name":"Division of Foodborne, Waterborne and Environmental Diseases, 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