{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:43:46Z","timestamp":1774543426986,"version":"3.50.1"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,7]]},"abstract":"<jats:p>Although the in-hospital mortality of Australian patients with melioidosis continues to decline, the ensuing clinical course of survivors is poorly described. Between January 1, 1998, and January 31, 2019, 228 patients in Cairns, tropical Australia, survived their hospitalization with melioidosis; however, 52 (23%) subsequently died. Death occurred at a median of 3.8 years after discharge, with patients dying at a mean age of 59 years. Only 1\/27 (4%) without predisposing conditions for melioidosis died during follow-up, versus 51\/201 (25%) with these comorbidities (<jats:italic>P<\/jats:italic> = 0.01). Death during follow-up was more likely in patients with chronic lung disease (OR [95% CI]: 4.05 (1.84\u20138.93, <jats:italic>P<\/jats:italic> = 0.001) and chronic kidney disease (OR [95% CI]: 2.87 [1.33\u20136.20], <jats:italic>P<\/jats:italic> = 0.007), and was most commonly due to infection and macrovascular disease. A significant proportion of Australians surviving hospitalization with melioidosis will die soon after discharge, usually prematurely and frequently from preventable conditions. A more holistic approach is required to their care.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0375","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T07:00:50Z","timestamp":1562050850000},"page":"328-331","source":"Crossref","is-referenced-by-count":21,"title":["High Rates of Premature and Potentially Preventable Death among Patients Surviving Melioidosis in Tropical Australia"],"prefix":"10.4269","volume":"101","author":[{"given":"Josh","family":"Hanson","sequence":"first","affiliation":[{"name":"Department of Medicine, Cairns Hospital, Cairns, Australia;"},{"name":"The Kirby Institute, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cairns Hospital, Cairns, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Nat 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1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"392","author":"GBD 2016 Alcohol Collaborators","year":"2018"},{"key":"b16","series-title":"Clin Microbiol Rev","first-page":"383","article-title":"Melioidosis: epidemiology, pathophysiology, and management","volume":"18","author":"Cheng","year":"2005"},{"key":"b17","series-title":"Sci Rep","first-page":"12143","article-title":"Infection with Burkholderia pseudomallei\u2013immune correlates of survival in acute melioidosis","volume":"7","author":"Dunachie","year":"2017"},{"key":"b18","series-title":"Eur J Immunol","article-title":"Diabetes alters immune response patterns to acute melioidosis in humans","author":"Kronsteiner","year":"2019"},{"key":"b19","series-title":"PLoS One","first-page":"e54961","article-title":"Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling","volume":"8","author":"Koh","year":"2013"}],"container-title":["The American 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