{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:45:50Z","timestamp":1772127950093,"version":"3.50.1"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,4]]},"abstract":"<jats:p>Recent data show that the gut microbiome plays a role in determining the clinical outcome of <jats:italic>Entamoeba histolytica<\/jats:italic> infection. We report the case of a patient who developed recurrent acute amebic colitis (second episode of acute colitis) after colonoscopy. Genotyping of <jats:italic>E. histolytica<\/jats:italic> revealed that she developed a second episode of acute amebic colitis with the same genotype as that of the first episode, indicating chronic infection had persisted asymptomatically for &gt; 10 months between the first and second episodes. Analysis of the gut microbiome, in addition to the clinical findings, suggested that dysbiosis at colonoscopy induced the change in the clinical form of <jats:italic>E. histolytica<\/jats:italic> infection from asymptomatic chronic infection to symptomatic colitis.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0396","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T07:00:36Z","timestamp":1570518036000},"page":"1384-1387","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Acute Amebic Colitis Triggered by Colonoscopy: Exacerbation of Asymptomatic Chronic Infection with Entamoeba histolytica Accompanied by Dysbiosis"],"prefix":"10.4269","volume":"101","author":[{"given":"Yasuaki","family":"Yanagawa","sequence":"first","affiliation":[{"name":"AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan;"},{"name":"Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Arisaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Parasitology, Dokkyo Medical University, Tochigi, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Nakada-Tsukui","sequence":"additional","affiliation":[{"name":"Department of Parasitology, National Institutes of Infectious Diseases, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhito","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Clinical Laboratory Medicine, Dokkyo Medical University, Tochigi, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Hiraishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Chigusa","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Parasitology, Dokkyo Medical University, Tochigi, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Gatanaga","sequence":"additional","affiliation":[{"name":"AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan;"},{"name":"Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Oka","sequence":"additional","affiliation":[{"name":"AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan;"},{"name":"Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyoshi","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Watanabe","sequence":"additional","affiliation":[{"name":"AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Open Forum Infect Dis","first-page":"ofy161","article-title":"A review of the global burden, new diagnostics, and current therapeutics for amebiasis","volume":"5","author":"Shieley","year":"2018"},{"key":"b2","series-title":"Lancet Infect Dis","first-page":"729","article-title":"Entamoeba histolytica infection in men who have sex with 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