{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:06:06Z","timestamp":1722470766611},"reference-count":9,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,4]]},"abstract":"<jats:p>Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are important proteins in the lectin pathway of the immune system. Mannose-binding lectin and MASP-2 deficiencies have been reported to be responsible for various fungal infections. We investigated the association of <jats:italic>MBL<\/jats:italic> and <jats:italic>MASP-2<\/jats:italic> variants with sporotrichosis in a Chinese population and revealed one rare heterozygous mutation in a disseminated cutaneous patient without immunosuppressive conditions (<jats:italic>MASP2<\/jats:italic>, p.156_159dupCHNH). We also found that sporotrichosis patients had decreased levels of MBL and MASP-2 in their serum samples compared with controls. Our findings linked, for the first time, <jats:italic>MASP-2<\/jats:italic> deficiencies with susceptibility to <jats:italic>Sporothrix<\/jats:italic> sp.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0470","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T07:01:08Z","timestamp":1569222068000},"page":"1322-1324","source":"Crossref","is-referenced-by-count":5,"title":["Mannose-Binding Lectin and Mannose-Binding Lectin-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis"],"prefix":"10.4269","volume":"101","author":[{"given":"Fangfang","family":"Bao","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;"},{"name":"Shandong Provincial Key Lab for Dermatovenereology, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi\u2019an","family":"Fu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;"},{"name":"Shandong Provincial Key Lab for Dermatovenereology, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gongqi","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;"},{"name":"Shandong Provincial Key Lab for Dermatovenereology, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;"},{"name":"Shandong Provincial Key Lab for Dermatovenereology, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;"},{"name":"Shandong Provincial Key Lab for Dermatovenereology, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases, Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China;"},{"name":"Shandong Provincial Key Lab for Dermatovenereology, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Future Microbiol","first-page":"85","article-title":"Sporothrix schenckii complex and sporotrichosis, an emerging health problem","volume":"6","author":"L\u00f3pez-Romero","year":"2011"},{"key":"b2","series-title":"Int J Infect Dis","first-page":"460","article-title":"Genetic variability of innate immunity impacts human susceptibility to fungal diseases","volume":"14","author":"Carvalho","year":"2010"},{"key":"b3","series-title":"Malar J","first-page":"61","article-title":"Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria","volume":"11","author":"Holmberg","year":"2012"},{"key":"b4","series-title":"J Biol Chem","first-page":"7844","article-title":"Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway","volume":"282","author":"Wallis","year":"2007"},{"key":"b5","series-title":"Am J Transplant","first-page":"1072","article-title":"Impact of MBL2 gene polymorphisms on the risk of infection in solid organ transplant recipients: a systematic review and meta-analysis","volume":"19","author":"Fern\u00e1ndez-Ruiz","year":"2019"},{"key":"b6","series-title":"Immunobiology","first-page":"42","article-title":"SNPs in 3\u2032-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels","volume":"224","author":"Kalia","year":"2019"},{"key":"b7","series-title":"Mol Immunol","first-page":"85","article-title":"MBL-associated serine proteases (MASPs) and infectious diseases","volume":"67","author":"Beltrame","year":"2015"},{"key":"b8","series-title":"J Immunol","first-page":"2939","article-title":"Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity","volume":"182","author":"Thiel","year":"2009"},{"key":"b9","series-title":"Genes Immun","first-page":"154","article-title":"Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms","volume":"8","author":"Thiel","year":"2007"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/101\/6\/article-p1322.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/101\/6\/article-p1322.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/101\/6\/article-p1322.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T15:35:47Z","timestamp":1722440147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/101\/6\/article-p1322.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":9,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.19-0470","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2019,12,4]]}}}