{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:45:57Z","timestamp":1778841957555,"version":"3.51.4"},"reference-count":25,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,5]]},"DOI":"10.4269\/ajtmh.19-0493","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T07:02:52Z","timestamp":1579590172000},"page":"562-566","source":"Crossref","is-referenced-by-count":16,"title":["Systematic, Point-of-Care Urine Lipoarabinomannan (Alere TB-LAM) Assay for Diagnosing Tuberculosis in Severely Immunocompromised HIV-Positive Ambulatory Patients"],"prefix":"10.4269","volume":"102","author":[{"given":"Helena","family":"Huerga","sequence":"first","affiliation":[{"name":"Epicentre, Paris, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loide","family":"Cossa","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Maputo, Mozambique;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Manhi\u00e7a","sequence":"additional","affiliation":[{"name":"National Tuberculosis Program, Ministry of Health, Maputo, Mozambique;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Bastard","sequence":"additional","affiliation":[{"name":"Epicentre, Paris, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Telnov","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Molfino","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Maputo, Mozambique;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Sanchez-Padilla","sequence":"additional","affiliation":[{"name":"Epicentre, Paris, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","volume-title":"Global Tuberculosis Report 2018","year":"2018"},{"key":"b2","volume-title":"Guidelines for Intensified Tuberculosis Case-Finding and Isoniazid Preventive Therapy for People Living with HIV in Resource-Constrained Settings","year":"2011"},{"key":"b3","volume-title":"Guidelines for Managing Advanced HIV Disease and Rapid Initiation of Antiretroviral Therapy, July 2017","year":"2017"},{"key":"b4","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0140-6736(15)01092-2","article-title":"Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial","volume":"387","author":"Peter","year":"2016","journal-title":"Lancet"},{"key":"b5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(18)31267-4","article-title":"Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind, randomised controlled trial","volume":"392","author":"Gupta-Wright","year":"2018","journal-title":"Lancet"},{"key":"b6","doi-asserted-by":"crossref","first-page":"e0156866","DOI":"10.1371\/journal.pone.0156866","article-title":"Diagnostic accuracy of lateral flow urine LAM assay for TB screening of adults with advanced immunosuppression attending routine HIV care in South Africa","volume":"11","author":"Hanifa","year":"2016","journal-title":"PLoS One"},{"key":"b7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1164\/rccm.201803-0490OC","article-title":"Yield and efficiency of novel intensified tuberculosis case-finding algorithms for people living with HIV","volume":"199","author":"Yoon","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"b8","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1093\/cid\/cix641","article-title":"Tuberculosis case finding with combined rapid point-of-care assays (Xpert MTB\/RIF and determine TB LAM) in HIV-positive individuals starting antiretroviral therapy in Mozambique","volume":"65","author":"Floridia","year":"2017","journal-title":"Clin Infect Dis"},{"key":"b9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12890-016-0316-z","article-title":"Rapid urine lipoarabinomannan assay as a clinic-based screening test for active tuberculosis at HIV diagnosis","volume":"16","author":"Drain","year":"2016","journal-title":"BMC Pulm Med"},{"key":"b10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1186\/s12879-015-1151-1","article-title":"Diagnostic accuracy of the rapid urine lipoarabinomannan test for pulmonary tuberculosis among HIV-infected adults in Ghana-findings from the DETECT HIV-TB study","volume":"15","author":"Bjerrum","year":"2015","journal-title":"BMC Infect Dis"},{"key":"b11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2334-14-110","article-title":"Diagnostic accuracy of a point-of-care urine test for tuberculosis screening among newly-diagnosed HIV-infected adults: a prospective, clinic-based study","volume":"14","author":"Drain","year":"2014","journal-title":"BMC Infect Dis"},{"key":"b12","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/tmi.12308","article-title":"Detection of lipoarabinomannan in urine for identification of active tuberculosis among HIV-positive adults in Ethiopian health centres","volume":"19","author":"Balcha","year":"2014","journal-title":"Trop Med Int Health"},{"key":"b13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1473-3099(11)70251-1","article-title":"Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study","volume":"12","author":"Lawn","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"b14","first-page":"CD011420","article-title":"Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in people living with HIV","volume":"10","author":"Bjerrum","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"b15","volume-title":"Lateral Flow Urine Lipoarabinomannan Assay (LF-LAM) for the Diagnosis of Active Tuberculosis in People Living with HIV\u2013Policy Update (2019)","year":"2019"},{"key":"b16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","article-title":"Bias reduction of maximum likelihood estimates","volume":"80","author":"Firth","year":"1993","journal-title":"Biometrika"},{"key":"b17","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/cid\/cix513","article-title":"Does disseminated nontuberculous mycobacterial disease cause false-positive determine TB-LAM lateral flow assay results? A retrospective review","volume":"65","author":"Nel","year":"2017","journal-title":"Clin Infect Dis"},{"key":"b18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/cid\/cix735","article-title":"Urinary lipoarabinomannan detection and disseminated nontuberculous mycobacterial disease","volume":"66","author":"Gupta-Wright","year":"2018","journal-title":"Clin Infect Dis"},{"key":"b19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12916-016-0603-9","article-title":"Detection of lipoarabinomannan (LAM) in urine is an independent predictor of mortality risk in patients receiving treatment for HIV-associated tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis","volume":"14","author":"Gupta-Wright","year":"2016","journal-title":"BMC Med"},{"key":"b20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/trstmh\/trw008","article-title":"Detection of lipoarabinomannan (LAM) in urine is indicative of disseminated TB with renal involvement in patients living with hiv and advanced immunodeficiency: evidence and implications","volume":"110","author":"Lawn","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"b21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1471-2334-12-103","article-title":"Point-of-care detection of lipoarabinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review","volume":"12","author":"Lawn","year":"2012","journal-title":"BMC Infect Dis"},{"key":"b22","doi-asserted-by":"crossref","first-page":"1672366","DOI":"10.1080\/16549716.2019.1672366","article-title":"Feasibility of using Determine TB-LAM to diagnose tuberculosis in HIV-positive patients in programmatic conditions: a multisite study","volume":"12","author":"Mathabire Rucker","year":"2019","journal-title":"Glob Health Action"},{"key":"b23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(09)70326-3","article-title":"Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysis","volume":"10","author":"Kranzer","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"b24","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1086\/429825","article-title":"High rates of clinical and subclinical tuberculosis among HIV-infected ambulatory subjects in Tanzania","volume":"40","author":"Mtei","year":"2005","journal-title":"Clin Infect Dis"},{"key":"b25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1164\/rccm.200606-759OC","article-title":"Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control","volume":"175","author":"Wood","year":"2007","journal-title":"Am J Respir Crit Care Med"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T17:37:16Z","timestamp":1611769036000},"score":1,"resource":{"primary":{"URL":"https:\/\/ajtmh.org\/doi\/10.4269\/ajtmh.19-0493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,5]]}},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.19-0493","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,5]]}}}