{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:37:52Z","timestamp":1779903472455,"version":"3.53.1"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,4]]},"abstract":"<jats:p>In July 2018, acute Q fever (AQF) was diagnosed in two Japanese individuals from the same family. They returned to Japan from Malawi, where the epidemiology of AQF is unknown. A child presented to the hospital with high-grade fever without any symptoms, and a mother presented with fever and dry cough. Paired serum antiphase \u2161 IgM and IgG significantly elevated in the convalescent phase in both cases. <jats:italic>Coxiella burnetii<\/jats:italic> gene (<jats:italic>IS1111<\/jats:italic>) was detected from the mother\u2019s blood sample. They had no reported direct animal contact, but the onset of symptoms coincided with the dry season in Malawi, which may have facilitated environmental dispersal. These cases may serve as an alert for high-risk people to possible AQF spread and underdiagnosis in Malawi.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0544","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T07:01:20Z","timestamp":1572332480000},"page":"1263-1264","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Two Cases of Acute Q Fever from the Same Family Who Returned from Malawi to Japan"],"prefix":"10.4269","volume":"101","author":[{"given":"Toshihiro","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"},{"name":"Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takato","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kutsuna","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Toriniwa","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Hokuriku University, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Komiya","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Hokuriku University, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Ohmagari","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Infect Dis Clin North Am","first-page":"505","article-title":"Q fever","volume":"22","author":"Tissot-Dupont","year":"2008"},{"key":"b2","series-title":"Travel Med Infect Dis","first-page":"159","article-title":"Clinical manifestations of Q fever in adults and children","volume":"5","author":"Terheggen","year":"2007"},{"key":"b3","series-title":"Lancet Infect 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study","volume":"7","author":"Crump","year":"2013"},{"key":"b8","series-title":"J Travel Med","first-page":"383","article-title":"Q fever in travelers: 10 cases","volume":"11","author":"Imbert","year":"2004"},{"key":"b9","series-title":"Clin Infect Dis","first-page":"82","article-title":"Concomitant or consecutive infection with Coxiella burnetii and tickborne diseases","volume":"40","author":"Rolain","year":"2005"},{"key":"b10","series-title":"Am J Trop Med Hyg","first-page":"1028","article-title":"Short report: Q fever and Plasmodium falciparum malaria co-infection in a patient returning from the Comoros archipelago","volume":"73","author":"Brouqui","year":"2005"},{"key":"b11","series-title":"Travel Med Infect Dis","first-page":"374","article-title":"Travel-associated Coxiella burnetii infections: three cases of Q fever with different clinical manifestation","volume":"5","author":"Kobbe","year":"2007"},{"key":"b12","series-title":"J Travel Med","first-page":"126","article-title":"Q 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