{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:36:17Z","timestamp":1763037377543},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,4]]},"abstract":"<jats:p>Urogenital schistosomiasis causes morbidity within the genitalia but is underreported and infrequently examined in men. To draw attention to male genital schistosomiasis (MGS), a longitudinal cohort study was conducted among fishermen along the southwestern shoreline of Lake Malawi. A case series of five participants is presented inclusive of questionnaire interviews, parasitological examinations, ultrasonography, and provision of a standard dose (40 mg\/kg) of praziquantel (PZQ) treatment at baseline, 1-, 3-, 6-, and 12-month follow-up time points. Eggs of <jats:italic>Schistosoma haematobium<\/jats:italic> were observed in urine or semen across all time points; parasitological diagnostics were bolstered by real-time PCR for <jats:italic>Schistosoma<\/jats:italic> DNA in semen and by portable ultrasonography to document putative MGS-associated morbidity. We highlight the importance of developing standard diagnostic tests for MGS and increasing the accessibility of PZQ treatment to men, especially those in at-risk endemic areas.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0562","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T07:01:12Z","timestamp":1572850872000},"page":"1331-1335","source":"Crossref","is-referenced-by-count":13,"title":["Case Report: Highlighting Male Genital Schistosomiasis (MGS) in Fishermen from the Southwestern Shoreline of Lake Malawi, Mangochi District"],"prefix":"10.4269","volume":"101","author":[{"given":"Sekeleghe A.","family":"Kayuni","sequence":"first","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"},{"name":"MASM Medi Clinics Limited, Medical Society of Malawi (MASM), Blantyre, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. James","family":"LaCourse","sequence":"additional","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Makaula","sequence":"additional","affiliation":[{"name":"Research for Health Environment and Development (RHED), Mangochi, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanuel","family":"Lampiao","sequence":"additional","affiliation":[{"name":"Physiology Department, College of Medicine, University of Malawi, Blantyre, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazarus","family":"Juziwelo","sequence":"additional","affiliation":[{"name":"National Schistosomiasis and STH Control Program, Community Health Sciences Unit (CHSU), Ministry of Health, Lilongwe, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Fawcett","sequence":"additional","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad H.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaco J.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Elisabeth-TweeSteden Hospital Tilburg, Laboratory for Medical Microbiology and Immunology, Tilburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Russell","family":"Stothard","sequence":"additional","affiliation":[{"name":"Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"year":"2009","series-title":"District Laboratory Practice in Tropical Countries, Part 1","author":"Cheesbrough","key":"b1"},{"year":"2010","series-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO","key":"b2"},{"key":"b3","series-title":"Parasitology","first-page":"1","article-title":"How can schistosome circulating antigen assays be best applied for diagnosing male genital schistosomiasis (MGS): an appraisal using exemplar MGS cases from a longitudinal cohort study among fishermen on the south shoreline of Lake Malawi","author":"Kayuni","year":"2019"},{"key":"b4","series-title":"Am J Trop Med Hyg","first-page":"1153","article-title":"Impact of short-time urine freezing on the 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in semen from Schistosoma haematobium\u2013infected individuals","volume":"191","author":"Leutscher","year":"2005"},{"key":"b20","series-title":"Int J Public Health","first-page":"839","article-title":"Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review","volume":"60","author":"Stecher","year":"2015"},{"key":"b21","series-title":"Open Forum Infect Dis","first-page":"ofx199","article-title":"Decrease in seminal HIV-1 RNA load after praziquantel treatment of urogenital schistosomiasis coinfection in HIV-positive men\u2013an observational study","volume":"4","author":"Midzi","year":"2017"}],"container-title":["The American Journal of Tropical Medicine and 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