{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:17:39Z","timestamp":1722471459541},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,4]]},"abstract":"<jats:p>African multimammate rats, <jats:italic>Mastomys natalensis<\/jats:italic>, are widely distributed in sub-Saharan Africa and live in close association with humans. In West Africa, numerous field studies have shown these animals may be naturally infected with the relapsing fever spirochete <jats:italic>Borrelia crocidurae<\/jats:italic>, the primary cause of tick-borne relapsing fever in this region of the continent. However, naturally infected individual rats have never been examined over time; therefore, the true host competency of these rats for this spirochete is unknown. Therefore, using animals from an established laboratory colony of <jats:italic>M. natalensis<\/jats:italic>, rats were experimentally infected with <jats:italic>B. crocidurae<\/jats:italic> and their blood examined to 28 days postinoculation. These animals were highly susceptible to infection and displayed prolonged and cyclic spirochetemias. Our results demonstrate these peridomestic rodents are likely competent hosts for infecting argasid tick vectors and play a primary role in the enzootic cycle for <jats:italic>B. crocidurae<\/jats:italic> in West Africa.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0590","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T07:01:06Z","timestamp":1572332466000},"page":"1272-1275","source":"Crossref","is-referenced-by-count":4,"title":["Host Competency of the Multimammate Rat Mastomys natalensis Demonstrated by Prolonged Spirochetemias with the African Relapsing Fever Spirochete Borrelia crocidurae"],"prefix":"10.4269","volume":"101","author":[{"given":"Kristin","family":"Boardman","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Rosenke","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Safronetz","sequence":"additional","affiliation":[{"name":"Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom G.","family":"Schwan","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS One","first-page":"e78473","article-title":"The epidemiology and geographic distribution of relapsing fever borreliosis in West and North Africa, with a review of the Ornithodoros erraticus complex (Acari: Ixodida)","volume":"11","author":"Trape","year":"2013"},{"key":"b2","series-title":"Bull Soc Path Exot","first-page":"280","article-title":"Spiroch\u00e8te de las musaraigne (Crocidura stampflii Jentink)","volume":"10","author":"Leger","year":"1917"},{"key":"b3","series-title":"Bull Soc Path Exot","first-page":"62","article-title":"Consid\u00e9rations sur la fi\u00e8vre r\u00e9currente a tiques au S\u00e9n\u00e9gal. 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