{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:00:51Z","timestamp":1777503651082,"version":"3.51.4"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:p>We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated <jats:italic>Plasmodium vivax<\/jats:italic> infection and treated with 30 mg\/kg body weight (BW) chloroquine for 3 days and 4.8 mg\/kg BW primaquine (PQ) to be taken over 14 days. The boy was discharged but represented 4 days later with severe hemoglobinuria and fatigue. Hemoglobin was measured at 6.0 g\/dL and serum bilirubin was at 5.6 mg\/dL, although malaria microscopy was negative. The boy had taken the 4-fold recommended daily dose of PQ and was treated with two fresh blood transfusions. Subsequent molecular analysis showed the boy to have the Mediterranean G6PD variant and a G6PD activity of 0.93 U\/gHb.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0643","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T07:01:15Z","timestamp":1572850875000},"page":"156-158","source":"Crossref","is-referenced-by-count":12,"title":["Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh"],"prefix":"10.4269","volume":"102","author":[{"given":"Ching Swe","family":"Phru","sequence":"first","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Golam","family":"Kibria","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamala","family":"Thriemer","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Divisions, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahtab Uddin","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Civil Surgeon\u2019s Office, Bandarban, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusrat","family":"Jahan","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Aktaruzzaman","sequence":"additional","affiliation":[{"name":"National Malaria Elimination Program, Directorate General of Health Services, Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisni","family":"Rahmat","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari Winasti","family":"Satyagraha","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aung Swi","family":"Prue","sequence":"additional","affiliation":[{"name":"Civil Surgeon\u2019s Office, Bandarban, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasif Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Ley","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Divisions, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Shafiul","family":"Alam","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Malaria MIS Report. National Malaria Elimination Program DCD, Directorate General of Health Services Ministry of Health & Family Welfare Government of Bangladesh","author":"NMEP","year":"2019"},{"key":"b2","series-title":"The Diagnosis and Management of Malaria (Early Diagnosis and Prompt Treatment) EDPT Learners Guide 2016","first-page":"5","author":"National Malaria Control Program DCD, Directorate General of Health Services Ministry of Health & Family Welfare Government of Bangladesh","year":"2016"},{"key":"b3","series-title":"Clin Infect Dis","first-page":"1336","article-title":"Primaquine therapy for malaria","volume":"39","author":"Baird","year":"2004"},{"key":"b4","series-title":"Malar J","first-page":"101","article-title":"Primaquine-induced haemolysis in females heterozygous for G6PD deficiency","volume":"17","author":"Chu","year":"2018"},{"key":"b5","series-title":"Guidelines for the Treatment of Malaria","author":"World Health Organization","year":"2015"},{"key":"b6","series-title":"Guide to G6PD Deficiency Rapid Diagnostic Testing to Support P. Vivax Radical Cure","author":"World Health Organization","year":"2018"},{"key":"b7","series-title":"BMC Res Notes","first-page":"855","article-title":"Spectrophotometry assays to determine G6PD activity from Trinity Biotech and Pointe Scientific G6PD show good correlation","volume":"11","author":"Alam","year":"2018"},{"key":"b8","series-title":"Genetics","first-page":"1849","article-title":"Nucleotide variability at G6pd and the signature of malarial selection in humans","volume":"162","author":"Saunders","year":"2002"},{"key":"b9","series-title":"World Health Organ Tech Rep Ser","first-page":"1","article-title":"Standardization of procedures for the study of glucose-6-phosphate dehydrogenase. Report of a WHO Scientific Group","volume":"366","author":"World Health Organization","year":"1967"},{"key":"b10","series-title":"Malar J","first-page":"134","article-title":"Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria","volume":"16","author":"Plewes","year":"2017"},{"key":"b11","series-title":"PLoS Med","first-page":"e1001339","article-title":"G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map","volume":"9","author":"Howes","year":"2012"},{"key":"b12","series-title":"Blood","first-page":"16","article-title":"Glucose-6-phosphate dehydrogenase deficiency: a historical perspective","volume":"111","author":"Beutler","year":"2008"},{"key":"b13","series-title":"Lancet","first-page":"929","article-title":"Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial","volume":"394","author":"Taylor","year":"2019"},{"key":"b14","series-title":"PloS One","first-page":"e0154015","article-title":"G6PD deficiency and antimalarial efficacy for uncomplicated malaria in Bangladesh: a prospective observational study","volume":"11","author":"Ley","year":"2016"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"281","article-title":"Hemoglobin E and glucose-6-phosphate dehydrogenase deficiency and Plasmodium falciparum malaria in the Chittagong Hill districts of Bangladesh","volume":"93","author":"Shannon","year":"2015"},{"key":"b16","series-title":"Plos Negl Trop Dis","first-page":"e0006230","article-title":"Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: divergent policies and practices in malaria endemic countries","volume":"12","author":"Recht","year":"2018"},{"key":"b17","series-title":"Malar J","first-page":"329","article-title":"Barriers to routine G6PD testing prior to treatment with primaquine","volume":"16","author":"Ley","year":"2017"},{"key":"b18","series-title":"Lancet","first-page":"1056","article-title":"Malaria eradication within a generation: ambitious, achievable, and necessary","volume":"394","author":"Feachem","year":"2019"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/102\/1\/article-p156.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/102\/1\/article-p156.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/102\/1\/article-p156.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T21:50:44Z","timestamp":1722462644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/102\/1\/article-p156.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":18,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.19-0643","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]}}}