{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:26:59Z","timestamp":1790303219079,"version":"4.1.0"},"reference-count":36,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,6]]},"abstract":"<jats:p>Following the large outbreak of Zika virus in the Western Hemisphere, many infants have been born with congenital Zika virus infection. It is important to describe the functional outcomes seen with congenital infections to allow for their recognition and appropriate interventions. We evaluated 120 children conceived during the 2015\u20132016 Zika virus outbreak in Para\u00edba, Brazil, who were approximately 24 months old, to assess functional outcomes. All children met either anthropometric criteria or laboratory criteria suggestive of possible congenital Zika virus infection. We collected results of previous medical evaluations, interviewed parents, and performed physical examinations and functional assessments, for example, the Hammersmith Infant Neurological Examination (HINE). We compared patterns of neurologic outcomes and developmental delay at age 24 months by whether children met anthropometric or laboratory criteria, or both. Among children meeting both criteria, 60% (26\/43) were multiply affected (had severe motor impairment, severe developmental delay, and suboptimal HINE scores), compared with 5% (3\/57) meeting only laboratory criteria and none (0\/20) meeting only anthropometric criteria. Of the remaining 91 children, 49% (45) had developmental delay, with more severe delay seen in children meeting both criteria. Although children meeting physical and laboratory criteria for potential congenital Zika virus infection were more severely affected, we did identify several children with notable adverse neurologic outcomes and developmental delay with no physical findings but potential laboratory evidence of Zika virus infection. Given this, all children who were potentially exposed in utero to Zika virus should be monitored in early childhood for deficits to allow for early intervention.<\/jats:p>","DOI":"10.4269\/ajtmh.19-0961","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T07:00:29Z","timestamp":1585638029000},"page":"955-963","source":"Crossref","is-referenced-by-count":22,"title":["Functional Outcomes among a Cohort of Children in Northeastern Brazil Meeting Criteria for Follow-Up of Congenital Zika Virus Infection"],"prefix":"10.4269","volume":"102","author":[{"given":"Jeanne","family":"Bertolli","sequence":"first","affiliation":[{"name":"Division of Human Development and Disability, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Elijah","family":"Attell","sequence":"additional","affiliation":[{"name":"Eagle Global Scientific, San Antonio, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Rose","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Moore","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio","family":"Melo","sequence":"additional","affiliation":[{"name":"Hospital Regional de Guarabira\/Governo do Estado da Para\u00edba, Jo\u00e3o Pessoa, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Erin","family":"Staples","sequence":"additional","affiliation":[{"name":"Division of Vector-Borne Diseases, CDC, Fort Collins, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Kotzky","sequence":"additional","affiliation":[{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"Krishna","sequence":"additional","affiliation":[{"name":"Office of Public Health Preparedness and Response, CDC, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Satterfield-Nash","sequence":"additional","affiliation":[{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Ornelas","family":"Pereira","sequence":"additional","affiliation":[{"name":"Transmissible Diseases Department (DEVIT), Ministry of Health of Brazil, Brasilia, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Hospital Infantil Albert Sabin, Fortaleza, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna Camille","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Congenital and Developmental Disorders, CDC, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Faria e Silva","family":"Santelli","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, Center for Global Health, CDC, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coleen A.","family":"Boyle","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, 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