{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:07:07Z","timestamp":1725494827027},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,9,1]]},"abstract":"<jats:p>Tyrosine aminotransferase (TAT), glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), and alkaline phosphatase (ALP) were measured in the serum and livers of <jats:italic>Microtus montanus<\/jats:italic> infected with <jats:italic>Trypanosoma brucei gambiense<\/jats:italic>. Only liver TAT and serum ALP showed significant changes. In addition, blood glucose, pyruvate and lactate, and liver glycogen levels were assayed. All four compounds showed significant changes, strongly suggesting increased glycogen mobilization and increased catabolic activity. Interestingly, the serum ketone levels were very low and no significant changes were observed. These chronically infected animals had an organic aciduria in which pyruvate, lactate, \u03b2-hydroxybutyrate, \u03b1-ketoglutarate, phenylpyruvate, and p-hydroxyphenylpyruvate were significantly increased. The possible significance of these observations is discussed.<\/jats:p>","DOI":"10.4269\/ajtmh.1987.37.314","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T17:05:05Z","timestamp":1494435905000},"page":"314-319","source":"Crossref","is-referenced-by-count":3,"title":["Further Biochemical Characterization of Chronic Trypanosoma Brucei Gambiense-Microtus Montanus Infection"],"prefix":"10.4269","volume":"37","author":[{"given":"John Richard","family":"Seed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Sechelski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Edwin","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Ann. Soc. Belg. Med. Trop.","first-page":"341","article-title":"A review on the use of Microtus montanus as an applicable experimental model for the study of African trypanosomiasis","volume":"60","author":"Seed","year":"1980"},{"key":"R2","series-title":"Am. J. Trop.\nMed. Hyg.","first-page":"968","article-title":"Experimental chronic Trypanosoma brucei rhodesiense infection in Microtus montanus","volume":"32","author":"Bafort","year":"1983"},{"key":"R3","series-title":"Molec. Biochem. Parasit.","first-page":"25","article-title":"Hepatic microsomal alterations during chronic\ntrypanosomiasis in the field vole, Microtus montanus","volume":"6","author":"Shertze","year":"1982"},{"key":"R4","series-title":"Trypanosoma brucei gambiense","first-page":"73","article-title":"Multiple alpha-keto aciduria in Microtus montanus chronically infected with Trypanosoma brucei gambiense","volume":"82B","author":"Hall","year":"1985"},{"key":"R5","series-title":"Contrib. Microbiol. Immunol.","first-page":"83","article-title":"A physiological mechanism to explain pathogenesis in African trypanosomiasis","volume":"7","author":"Seed","year":"1983"},{"key":"R6","series-title":"Comp. Biochem. Physiol.","first-page":"209","article-title":"Phenylalanine metabolism in Microtus montanus chronically infected with Trypanosoma brucei gambiense","volume":"71B","author":"Seed","year":"1982"},{"key":"R7","series-title":"Exp. Parasitol.","first-page":"521","article-title":"Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose","volume":"28","author":"Lanham","year":"1970"},{"key":"R8","series-title":"Anal. Chim. Acta","first-page":"238","article-title":"The precipitation of carbonyl compounds with 2,4-dinitrophenylhydrazine. Formation of isomeric dinitrophenylhydrazones","volume":"7","author":"Neuberg","year":"1952"},{"key":"R9","series-title":"J. Infect. Dis.","first-page":"653","article-title":"Reduced levels of glycogen and glucose-6-phosphatase in livers of guinea pigs infected with Trypanosoma gambiens","volume":"121","author":"Marciacq","year":"1970"},{"key":"R10","series-title":"Science","first-page":"254","article-title":"Quantitative determination of carbohydrates with Dreywood's anthrone reagent","volume":"107","author":"Morris","year":"1948"},{"key":"R11","series-title":"Standard Methods in Clinical Chemistry","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/B978-0-12-609106-9.50029-4","article-title":"Enzymatic methods for lactic and pyruvic acids","volume":"Volume 6","author":"Fleisher","year":"1970"},{"key":"R12","series-title":"Anal. Biochem.","first-page":"395","article-title":"Assay of tyrosine transaminase activity by conversion of p-hydroxyphenylpyruvate to p-hydroxybenzaldehyde","volume":"16","author":"Diamondstone","year":"1966"},{"key":"R13","series-title":"Exp. Parasit.","first-page":"1","article-title":"Elevated serum and hepatic tyrosine amino transferase in voles chronically infected with Trypanosoma brucei gambiense","volume":"39","author":"Stibbs","year":"1976"},{"key":"R14","series-title":"Am. J. Clin. Pathol.","first-page":"56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957"},{"key":"R15","series-title":"Clin. Chimi. Acta","first-page":"63","article-title":"Standardization of the alkaline phosphatase determination\nwith human placental phosphatase","volume":"59","author":"Hafkenschei","year":"1975"},{"key":"R16","series-title":"Infect. Immun.","first-page":"707","article-title":"Genetic resistance to Trypanosoma congolense infections in mice","volume":"27","author":"Whitelaw","year":"1980"},{"year":"1966","series-title":"Biochemistry of Parasites","author":"von Brand","key":"R17"},{"key":"R18","series-title":"Comp. Biochem. Physiol.","first-page":"379","article-title":"Biochemical studies on the vole, Microtus montanus. II. The effects of a Trypanosoma brucei gambiense infection on the diurnal variation of hepatic glucose- 6-phosphate and liver glycogen","volume":"45","author":"Ashman","year":"1973"},{"key":"R19","series-title":"J. Parasitol.","first-page":"499","article-title":"Tissue fluid in rabbits infected with Trypanosoma (Trypanozoon) brucei","volume":"66","author":"Goodwin","year":"1973"},{"key":"R20","series-title":"J. Parasitol.","first-page":"15","article-title":"Alteration of free serum amino acids in voles infected with Trypanosoma brucei gambiense","volume":"63","author":"Newport","year":"1977"},{"key":"R21","series-title":"Comp. Biochem. Physiol.","first-page":"447","article-title":"Liver glycogen mobilization by Trypanosoma brucei sonicates","volume":"70B","author":"Sanchez","year":"1981"},{"key":"R22","series-title":"J. Parasitol.","first-page":"143","article-title":"Effects of Trypanosoma brucei gambiense infection of incorporation of 14C-tryptophan by Microtus montanus","volume":"61","author":"Stibbs","year":"1975"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/37\/2\/article-p314.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/37\/2\/article-p314.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/37\/2\/article-p314.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T19:50:14Z","timestamp":1725479414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/37\/2\/article-p314.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9,1]]},"references-count":22,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.1987.37.314","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[1987,9,1]]}}}