{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:32:50Z","timestamp":1787031170484,"version":"build-2736575974"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lobomycosis, also referred to as lacaziosis, is an endemic cutaneous and subcutaneous fungal disease that mainly affects Amazonian forest dwellers in Brazil. There is no disease control program in place in Brazil, and antifungal therapy failures are common, and the therapy is inaccessible to most patients. We performed a randomized, unblinded clinical trial testing the cure rate of multiple drug therapy (MDT) for leprosy with surgical excision, with or without itraconazole. A control arm consisted of patients who did not adhere to either therapeutic regimens but continued to be followed up. Multiple drug therapy consisted of monthly supervised doses of 600 mg rifampicin, 300 mg clofazimine, and 100 mg dapsone, in addition to daily doses of 50 mg clofazimine and 100 mg dapsone. The patients in the MDT plus itraconazole arm also received itraconazole 100 mg twice daily. We followed up 54 patients from the MDT group and 26 patients from the MDT plus itraconazole group for an average of 4 years and 9 months. The 23 controls were followed up for 6 months on average. The following endpoints were observed: 1) unchanged (no apparent improvement), 2) improved (reduction in lesion size and\/or pruritus), and 3) cured (complete remission of the lesions, no viable fungi, and no relapse for 2 years after the end of the drug treatment). The results indicated a significantly greater likelihood of cure associated with the use of multidrug therapy for leprosy with or without itraconazole when compared with the control group. The addition of itraconazole to MDT was not associated with improved outcomes, suggesting that MDT alone is effective.<\/jats:p>","DOI":"10.4269\/ajtmh.20-0090","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T02:00:30Z","timestamp":1605578430000},"page":"634-639","source":"Crossref","is-referenced-by-count":13,"title":["Multidrug Therapy for Leprosy Can Cure Patients with Lobomycosis in Acre State, Brazil: A Proof of Therapy Study"],"prefix":"10.4269","volume":"104","author":[{"given":"Franciely Gomes","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"1Setor de P\u00f3s-gradua\u00e7\u00e3o, Pesquisa e Inova\u00e7\u00e3o, Centro Universit\u00e1rio Sa\u00fade ABC, Funda\u00e7\u00e3o ABC, Santo Andr\u00e9, Brazil;"},{"name":"2Laborat\u00f3rio Pesquisa do Centro Universit\u00e1rio Uninorte (UNINORTE), Rio Branco, Brazil;"},{"name":"3Servi\u00e7o Estadual de Dermatologia do Acre, Programa Estadual de Dermatologia do Acre, Programa Estadual de Controle da Hansen\u00edase (SESACRE), Rio Branco, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Sammarco","family":"Rosa","sequence":"additional","affiliation":[{"name":"4Divis\u00e3o de Pesquisa e Ensino, Instituto Lauro de Souza Lima, Bauru, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"de Farias Fernandes Belone","sequence":"additional","affiliation":[{"name":"4Divis\u00e3o de Pesquisa e Ensino, Instituto Lauro de Souza Lima, Bauru, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9ia Borges","family":"Carneiro","sequence":"additional","affiliation":[{"name":"3Servi\u00e7o Estadual de Dermatologia do Acre, Programa Estadual de Dermatologia do Acre, Programa Estadual de Controle da Hansen\u00edase (SESACRE), Rio Branco, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia L\u00facia","family":"Queiroz de Barros","sequence":"additional","affiliation":[{"name":"3Servi\u00e7o Estadual de Dermatologia do Acre, Programa Estadual de Dermatologia do Acre, Programa Estadual de Controle da Hansen\u00edase (SESACRE), Rio Branco, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosineide Ferreira","family":"Bispo","sequence":"additional","affiliation":[{"name":"3Servi\u00e7o Estadual de Dermatologia do Acre, Programa Estadual de Dermatologia do Acre, Programa Estadual de Controle da Hansen\u00edase (SESACRE), Rio Branco, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yally","family":"Alves da Silva Sbardelott","sequence":"additional","affiliation":[{"name":"3Servi\u00e7o Estadual de Dermatologia do Acre, Programa Estadual de Dermatologia do Acre, Programa Estadual de Controle da Hansen\u00edase (SESACRE), Rio Branco, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e3o Afonso","family":"Viana Macedo Neves","sequence":"additional","affiliation":[{"name":"5Universidade Federal do Acre, Rio Branco, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Y.","family":"Vittor","sequence":"additional","affiliation":[{"name":"6Division of Infectious Diseases and Global Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William John","family":"Woods","sequence":"additional","affiliation":[{"name":"3Servi\u00e7o Estadual de Dermatologia do Acre, Programa Estadual de Dermatologia do Acre, Programa Estadual de Controle da Hansen\u00edase (SESACRE), Rio Branco, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Zorello","family":"Laporta","sequence":"additional","affiliation":[{"name":"1Setor de P\u00f3s-gradua\u00e7\u00e3o, Pesquisa e Inova\u00e7\u00e3o, Centro Universit\u00e1rio Sa\u00fade ABC, Funda\u00e7\u00e3o ABC, Santo Andr\u00e9, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/2\/article-p634.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/2\/article-p634.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T20:48:44Z","timestamp":1612817324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/2\/article-p634.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-0090","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739061212.793584777","asserted-by":"object"}]},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]}}}