{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:11:41Z","timestamp":1782425501615,"version":"3.54.5"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Undifferentiated febrile illness still represents a demanding medical problem all over the world, but primarily in low- and middle-income countries. Scientific and clinical investigations related to undifferentiated febrile illness and rickettsial diseases in Kazakhstan are lacking. This study reflects the investigation of antibodies against spotted fever group (SFG) and typhus group (TG) rickettsiae in patients with undifferentiated febrile illness in the southern region of Kazakhstan (Almaty and Kyzylorda oblasts). Paired serum samples were gathered from 13 hospitals in these two oblasts and explored for the presence of IgM and IgG antibodies against typhus group and IgG antibodies against spotted fever group rickettsiae using ELISA. Patient\u2019s questionnaires were statistically analyzed. In total, 802 inpatients from Almaty (<jats:italic>N<\/jats:italic> = 9) and Kyzylorda (<jats:italic>N<\/jats:italic> = 4) hospitals were included in this research. Based on ELISA results, 250 patients out of 802 (31.2%) from both oblasts had IgG antibodies against SFG rickettsiae. Results from 11 (1.4%) patients indicated acute infection with tick-borne rickettsiosis. Regarding TG rickettsiae (<jats:italic>R. typhi<\/jats:italic>), a past infection was detected in 248 (30.9%) febrile patients and acute infection in 22 (2.7%) patients in the two selected oblasts. The data indicated that SFG and TG rickettsioses are present in Kazakhstan. Kazakh physicians should be aware of these emerging diseases in both investigated oblasts because the occurrence of these diseases is not suspected during day-to-day clinical practice. The identification of rickettsial pathogens and implementation of modern laboratory methods for the diagnostics of rickettsioses are in need throughout Kazakhstan.<\/jats:p>","DOI":"10.4269\/ajtmh.20-0388","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:31:28Z","timestamp":1619443888000},"page":"2000-2008","source":"Crossref","is-referenced-by-count":6,"title":["Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan"],"prefix":"10.4269","volume":"104","author":[{"given":"Nurkeldi","family":"Turebekov","sequence":"first","affiliation":[{"name":"1Central Reference Laboratory, National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlygash","family":"Abdiyeva","sequence":"additional","affiliation":[{"name":"1Central Reference Laboratory, National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravilya","family":"Yegemberdiyeva","sequence":"additional","affiliation":[{"name":"2Department of Infectious and Tropical Diseases, Kazakh National Medical University, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"3National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Dmitrovskiy","sequence":"additional","affiliation":[{"name":"3National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyazzat","family":"Yeraliyeva","sequence":"additional","affiliation":[{"name":"4Department of Children\u2019s Infectious Diseases, Kazakh National Medical University, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna","family":"Shapiyeva","sequence":"additional","affiliation":[{"name":"5Scientific Practical Center of Sanitary Epidemiological Expertise and Monitoring, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinara","family":"Batyrbayeva","sequence":"additional","affiliation":[{"name":"6Scientific Clinical Diagnostic Laboratory, Kazakh National Medical University, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur","family":"Tukhanova","sequence":"additional","affiliation":[{"name":"7Center for International Health, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Shin","sequence":"additional","affiliation":[{"name":"7Center for International Health, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyazzat","family":"Musralina","sequence":"additional","affiliation":[{"name":"8Al-Farabi Kazakh National University, Almaty, Kazakhstan;"},{"name":"9Institute of General Genetics and Cytology, Almaty, Kazakhstan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hoelscher","sequence":"additional","affiliation":[{"name":"10Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universit\u00e4t, German Center for Infection Research, Munich Partner site, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenter","family":"Froeschl","sequence":"additional","affiliation":[{"name":"7Center for International Health, Ludwig-Maximilians-Universit\u00e4t, Munich, Germany;"},{"name":"10Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-Universit\u00e4t, German Center for Infection Research, Munich Partner site, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Dobler","sequence":"additional","affiliation":[{"name":"11Bundeswehr Institute of Microbiology, Department Virology & Rickettsiology, German Center for Infection Research, Munich Partner site, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Freimueller","sequence":"additional","affiliation":[{"name":"11Bundeswehr Institute of Microbiology, Department Virology & Rickettsiology, German Center for Infection Research, Munich Partner site, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Wagner","sequence":"additional","affiliation":[{"name":"11Bundeswehr Institute of Microbiology, Department Virology & Rickettsiology, German Center for Infection Research, Munich Partner site, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Frey","sequence":"additional","affiliation":[{"name":"11Bundeswehr Institute of Microbiology, Department Virology & Rickettsiology, German Center for Infection Research, Munich Partner site, Munich, Germany;"},{"name":"12Bundeswehr Research Institute for Protective Technologies and CBRN Protection, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Essbauer","sequence":"additional","affiliation":[{"name":"11Bundeswehr Institute of Microbiology, Department Virology & Rickettsiology, German Center for Infection Research, Munich Partner site, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2000.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/6\/article-p2000.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T16:39:43Z","timestamp":1622651983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2000.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,2]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-0388","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,2]]}}}