{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:56:24Z","timestamp":1760885784780},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hepatitis C virus (HCV) infection can affect the neurological system, and neuropathy is one of these manifestations. Hepatitis C virus infection is associated with diabetes mellitus (DM) type II, and diabetic patients are at higher risk of acquiring HCV infection. Sweat function has been proposed to assess early autonomic neuropathy. This study aimed to evaluate small fiber neuropathy in asymptomatic HCV-related cirrhotic patients with or without DM through sweat function assessment by Sudoscan test. Three groups were involved: 47 healthy controls, 48 HCV-related cirrhotic patients without DM (group 1), and 49 HCV-related cirrhotic patients with DM type II (group 2). All participants were subjected to liver panel tests, renal function tests, cell blood counts, HbA1c, and abdominal ultrasound. Sweat function was assessed in all patients and controls by measuring hand and feet electrochemical skin conductance (ESC, microSiemens [\u00b5S]) using Sudoscan. Peripheral neuropathy was detected in none of the controls, 39% of group 1 patients, and 62% of group 2 patients (<jats:italic>P<\/jats:italic> &lt; 0.0001). The mean feet ESC (FESC) was 88.3 \u00b1 6.8 \u00b5S in controls, 67.2 \u00b1 19.2 \u00b5S in group 1, and 57.9 \u00b1 19.4 \u00b5S in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.0001). A significant correlation was observed between FESC and bilirubin, albumin, creatinine, international normalized ratio, transaminases, and splenic size. Electrochemical skin conductance measurement is a valuable, noninvasive method for early detection of small fiber neuropathy in asymptomatic HCV-related cirrhosis, with or without DM.<\/jats:p>","DOI":"10.4269\/ajtmh.20-0612","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T07:05:51Z","timestamp":1606201551000},"page":"580-584","source":"Crossref","is-referenced-by-count":4,"title":["Sudomotor Changes in Hepatitis C Virus Infection with or without Diabetes Mellitus: A Pilot Study in Egyptian Patients"],"prefix":"10.4269","volume":"104","author":[{"given":"El-Sayed","family":"Tharwa","sequence":"first","affiliation":[{"name":"1Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar","family":"Mohamed","sequence":"additional","affiliation":[{"name":"1Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmy","family":"Elshazly","sequence":"additional","affiliation":[{"name":"1Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Salama","sequence":"additional","affiliation":[{"name":"1Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed I.","family":"Youssef","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Al-Azhar University, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Saied","family":"Bakeer","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Al-Azhar University, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimaa Y.","family":"Kamel","sequence":"additional","affiliation":[{"name":"3Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabry Moawad","family":"Abdelmageed","sequence":"additional","affiliation":[{"name":"4Department of Clinical Biochemistry and Molecular Diagnostics, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HosamEldeen Salah","family":"Shabana","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Al-Azhar University, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Abdelrashed","family":"Allam","sequence":"additional","affiliation":[{"name":"2Department of Internal Medicine, Al-Azhar University, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherief M.","family":"Al Shazly","sequence":"additional","affiliation":[{"name":"5Department of Neurology, Al-Azhar University, Damietta, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsayed Fathi Ali","family":"Hamed","sequence":"additional","affiliation":[{"name":"5Department of Neurology, Al-Azhar University, Damietta, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan Yousef","family":"Zied","sequence":"additional","affiliation":[{"name":"6Ministry of Health and Population, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa","family":"Elwazzan","sequence":"additional","affiliation":[{"name":"7Department of Tropical Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally Waheed","family":"Elkhadry","sequence":"additional","affiliation":[{"name":"8Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya Mohammed","family":"Mahros","sequence":"additional","affiliation":[{"name":"9Gastroenterology, Hepatology and Infectious Disease Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Hussien","family":"Ahmed","sequence":"additional","affiliation":[{"name":"9Gastroenterology, Hepatology and Infectious Disease Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad AbdElhameed Ahmed","family":"Alwaseef","sequence":"additional","affiliation":[{"name":"10Clinical Pathology Department, Al-Azhar University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdel-Samiee","sequence":"additional","affiliation":[{"name":"1Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/2\/article-p580.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/2\/article-p580.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T01:38:28Z","timestamp":1612834708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/2\/article-p580.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.20-0612","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]}}}